TAT-CIRP 

TAT-CIRP is a a small peptide, refers to Trans-trans-activating (Tat)-cold-inducible RNA binding protein. TAT-CIRP is an inhibitor of myeloid differentiation protein 2 (MD2). TAT-CIRP exhibits robust neuroprotection against ischemic and hemorrhagic stroke in mice^[1].

TAT-CIRP (5 μM) alleviates apoptosis and necroptosis induced by NMDA stimulation (50 μM; 1 h), through a TLR4-independent pathway, in neuronal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAT-CIRP (5-20mg/kg) alleviates brain damage after ischemic stroke in mice with middle cerebral artery (MCA) occlusion (MCAO). As for Tat, the cell membrane transduction domain of human immunodeficiency virus type 1, can be used as a control peptide^[1].
TAT-CIRP (20 mg/kg; iv; single dose) can pass through the blood-brain barrier (BBB) in mice, with C_max value of 4762.6 μg/L, and half-life about 90 min^[1].
TAT-CIRP (20 mg/kg, 100 mg/kg; iv; once daily for 7 days) induces little toxicity in mice, with safety profile^[1].
TAT-CIRP reduces cerebral ischemic injury in rhesus monkey^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2997.31

C₁₂₃H₂₀₆N₅₆O₃₃

Solid

White to off-white

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly

YGRKKRRQRRRGRGFSRGGGDRGYGG

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Fang Z, et al. An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Sci Transl Med. 2021 Jun 9;13(597):eabb6716.  [Content Brief]