2. Cytoskeleton
  3. Integrin
  4. TC-I 15

TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, .

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TC-I 15 Chemical Structure

TC-I 15 Chemical Structure

CAS No. : 916734-43-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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 USD 206 In-stock
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10 mM * 1 mL in DMSO USD 206 In-stock
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Based on 1 publication(s) in Google Scholar

TC-I 15 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TC-I 15

View All Integrin Isoform Specific Products:

View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin α2β1 inhibitor, and it also inhibits α1β1 and α11β1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, [1][2].

IC50 & Target

α2β1

0.4 (α2β1 μM (IC50)

α2β1

26.8 (α2β1 μM (IC50)

α1β1

23.6 (α1β1 μM (IC50)

α1β1

24.4 (α1β1 μM (IC50)

α11β1

177 (α11β1 μM (IC50)

α11β1

3177 (α11β μM (IC50)

In Vitro

TC-I 15 (0-500 μM, 1 h) inhibits the adhesion of C2C12 cells expressing α2β1 in a dose-dependent manner, with IC50 values of 26.8 μM and 0.4 μM for GFOGER and GLOGEN, respectively[1].
TC-I 15 (0-500μM, 1 h) also inhibited α1β1, showing IC50 values of 23.6 μM for GFOGER and 24.4 μM for GLOGEN[1].
TC-I 15 (0-50μM, 1 h) inhibits the adhesion of HT1080 cells to GFOGER[1].
TC-I 15 (0-50μM, 1 h) inhibits the uptake of EVs by LFs cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TC-I 15 Related Antibodies

Western Blot Analysis[2]

Cell Line: LFs
Concentration: 0, 0.5, 1, 2 μM
Incubation Time: 1 h
Result: Inhibited LFs uptake of EVs, inhibited LF activation induced by EVs, and inhibited the expression of p-Smad3 and POSTN.
In Vivo

TC I-15 (10 μg; intravenous injection; every other day; for three weeks) inhibits lung metastasis promoted by CAFs EVs in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 J mice[2]
Dosage: 10 μg; every other day for 3 weeks; once every 2 weeks for 3 weeks
Administration: Intravenous injection (i.v.)
Result: Inhibited the formation of pre-metastatic microenvironment induced by EVs, inhibited SACC lung metastasis induced by EVs, and significantly increased integrin β1 of EVs.
Molecular Weight

520.62

Formula

C23H28N4O6S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[S](N(CSC(C)1C)[C@@H]1C(N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O)(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (480.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9208 mL 9.6039 mL 19.2079 mL
5 mM 0.3842 mL 1.9208 mL 3.8416 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9208 mL 9.6039 mL 19.2079 mL 48.0197 mL
5 mM 0.3842 mL 1.9208 mL 3.8416 mL 9.6039 mL
10 mM 0.1921 mL 0.9604 mL 1.9208 mL 4.8020 mL
15 mM 0.1281 mL 0.6403 mL 1.2805 mL 3.2013 mL
20 mM 0.0960 mL 0.4802 mL 0.9604 mL 2.4010 mL
25 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.9208 mL
30 mM 0.0640 mL 0.3201 mL 0.6403 mL 1.6007 mL
40 mM 0.0480 mL 0.2401 mL 0.4802 mL 1.2005 mL
50 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
60 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8003 mL
80 mM 0.0240 mL 0.1200 mL 0.2401 mL 0.6002 mL
100 mM 0.0192 mL 0.0960 mL 0.1921 mL 0.4802 mL
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TC-I 15 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-I 15916734-43-5Integrincollagen-binding integrinGFOGERGLOGENplatelet adhesionthrombus depositioncell adhesionInhibitorinhibitorinhibit

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