Tectoquinone (Synonyms: 2-Methylanthraquinone)

Cat. No.: HY-N1739 Purity: 98.21%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Tectoquinone (2-Methylanthraquinone) is a SARSCoV-2 main protease inhibitor against COVID-19. Tectoquinone exhibits strong mosquito larvicidal activity with the LC₅₀ values of 3.3 and 5.4 μg/ml against A. aegypti and A. albopictus in 24 h, respectively.

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Tectoquinone Chemical Structure

CAS No. : 84-54-8

Size	Stock	Quantity

Free Sample (0.1 - 0.5 mg)	Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Tectoquinone:

Tectoquinone (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μg/mL Compound: 4	Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
ACHN	EC₅₀	> 50 μM Compound: 3	Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay	[PMID: 22313254]
ACHN	EC₅₀	> 50 μM Compound: 3	Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL Cytotoxicity against human ACHN cells assessed as cell death after 20 to 24 hrs by XTT assay in presence of 40 ng/ml TRAIL	[PMID: 22313254]
CCRF-CEM	IC₅₀	> 10 μg/mL Compound: 5	Cytotoxicity against human CEM cells after 3 days by MTT assay Cytotoxicity against human CEM cells after 3 days by MTT assay	[PMID: 11421746]
EMT6	ED₅₀	0.54 μM Compound: 1	Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under hypoxic condition. Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under hypoxic condition.	[PMID: 7452674]
EMT6	ED₅₀	1.7 μM Compound: 1	Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under aerobic condition. Compound is measured for surviving fractions of EMT6 tumor cells treated in culture with (0.50 uM) concentration for 1 hr under aerobic condition.	[PMID: 7452674]
HL-60	IC₅₀	> 10 μg/mL Compound: 5	Cytotoxicity against human HL60 cells after 3 days by MTT assay Cytotoxicity against human HL60 cells after 3 days by MTT assay	[PMID: 11421746]
HT-29	IC₅₀	> 100 μg/mL Compound: 4	Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
HUVEC	IC₅₀	> 100 μg/mL Compound: 4	Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HUVEC cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
MCF7	IC₅₀	> 100 μg/mL Compound: 4	Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26995526]
SW1573	IC₅₀	> 10 μg/mL Compound: 5	Cytotoxicity against human SW1573 cells after 3 days by MTT assay Cytotoxicity against human SW1573 cells after 3 days by MTT assay	[PMID: 11421746]

Molecular Weight

222.24

Formula

C₁₅H₁₀O₂

CAS No.

84-54-8

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C2=C(C=CC=C2)C(C3=CC=C(C)C=C13)=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (56.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4996 mL	22.4982 mL	44.9964 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.40%

Select Batch:

Data Sheet (273 KB) SDS (392 KB)

COA (250 KB) HNMR (130 KB) RP-HPLC (284 KB)

Handling Instructions (2659 KB)

References

[1]. Sen-Sung Cheng, et al. Larvicidal activity of tectoquinone isolated from red heartwood-type Cryptomeria japonica against two mosquito species. Bioresour Technol. 2008 Jun;99(9):3617-22. [Content Brief]

[2]. Anoop Kallingal, et al. Molecular modeling study of tectoquinone and acteoside from Tectona grandis linn: a new SARS-CoV-2 main protease inhibitor against COVID-19. J Biomol Struct Dyn. 2022 Mar;40(4):1764-1775. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4996 mL	22.4982 mL	44.9964 mL	112.4910 mL
	5 mM	0.8999 mL	4.4996 mL	8.9993 mL	22.4982 mL
	10 mM	0.4500 mL	2.2498 mL	4.4996 mL	11.2491 mL
	15 mM	0.3000 mL	1.4999 mL	2.9998 mL	7.4994 mL
	20 mM	0.2250 mL	1.1249 mL	2.2498 mL	5.6245 mL
	25 mM	0.1800 mL	0.8999 mL	1.7999 mL	4.4996 mL
	30 mM	0.1500 mL	0.7499 mL	1.4999 mL	3.7497 mL
	40 mM	0.1125 mL	0.5625 mL	1.1249 mL	2.8123 mL
	50 mM	0.0900 mL	0.4500 mL	0.8999 mL	2.2498 mL

Tectoquinone Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tectoquinone84-54-82-MethylanthraquinoneSARS-CoVVirus ProteaseSARS coronavirusSARSCoV-2proteaseCOVID-19mosquito larvicidalA. aegyptiA. albopictusInhibitorinhibitorinhibit

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Tectoquinone (Synonyms: 2-Methylanthraquinone)

Customer Review

Other Forms of Tectoquinone:

Tectoquinone Related Antibodies

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Biological Activity

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References

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Tectoquinone Related Classifications

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