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Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure.

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Tempone Chemical Structure

Tempone Chemical Structure

CAS No. : 2896-70-0

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Description

Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure[1].

Molecular Weight

170.23

Formula

C9H16NO2*
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

[O]N1C(C)(C)CC(CC1(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (176.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8744 mL 29.3720 mL 58.7441 mL
5 mM 1.1749 mL 5.8744 mL 11.7488 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8744 mL 29.3720 mL 58.7441 mL 146.8601 mL
5 mM 1.1749 mL 5.8744 mL 11.7488 mL 29.3720 mL
10 mM 0.5874 mL 2.9372 mL 5.8744 mL 14.6860 mL
15 mM 0.3916 mL 1.9581 mL 3.9163 mL 9.7907 mL
20 mM 0.2937 mL 1.4686 mL 2.9372 mL 7.3430 mL
25 mM 0.2350 mL 1.1749 mL 2.3498 mL 5.8744 mL
30 mM 0.1958 mL 0.9791 mL 1.9581 mL 4.8953 mL
40 mM 0.1469 mL 0.7343 mL 1.4686 mL 3.6715 mL
50 mM 0.1175 mL 0.5874 mL 1.1749 mL 2.9372 mL
60 mM 0.0979 mL 0.4895 mL 0.9791 mL 2.4477 mL
80 mM 0.0734 mL 0.3672 mL 0.7343 mL 1.8358 mL
100 mM 0.0587 mL 0.2937 mL 0.5874 mL 1.4686 mL
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Tempone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tempone2896-70-04-Oxo-TempoOthersFree radicalsMRIcontrast agentsacute kidney failureInhibitorinhibitorinhibit

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