Tempone (Synonyms: 4-Oxo-Tempo)

Cat. No.: HY-129242: FAQs
Data Sheet Handling Instructions

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Tempone (4-Oxo-Tempo) is a stable water-soluble nitro radical. Tempone is widely used as a contrast agent for metabolic activity and hypoxic sensitivity in electron spin resonance spectroscopy, magnetic resonance imaging and dynamic nuclear polarization. Tempone reduces superoxide radicals by mimicking the activity of superoxide dismutase (SOD), thereby reducing the formation of hydroxyl radicals and peroxynitrites. Tempone can be used in the study of ischemia-reperfusion injury and acute renal failure.

For research use only. We do not sell to patients.

Tempone Chemical Structure

CAS No. : 2896-70-0

Size	Price	Stock
1 g	USD 30	Ask For Quote & Lead Time
5 g	USD 90	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Tempone:

Tempone-¹⁵N,d₁₆ Get quote
Tempone-d₁₆ Get quote

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Purity & Documentation
References
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Description

Molecular Weight

170.23

Formula

C₉H₁₆NO₂^*

CAS No.

2896-70-0

Appearance

Solid

Color

Yellow to brown

SMILES

[O]N1C(C)(C)CC(CC1(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 30 mg/mL (176.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8744 mL	29.3720 mL	58.7441 mL
5 mM	1.1749 mL	5.8744 mL	11.7488 mL
10 mM	0.5874 mL	2.9372 mL	5.8744 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Patel N S A, et al. TEMPONE reduces renal dysfunction and injury mediated by oxidative stress of the rat kidney[J]. Free Radical Biology and Medicine, 2002, 33(11): 1575-1589. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8744 mL	29.3720 mL	58.7441 mL	146.8601 mL
	5 mM	1.1749 mL	5.8744 mL	11.7488 mL	29.3720 mL
	10 mM	0.5874 mL	2.9372 mL	5.8744 mL	14.6860 mL
	15 mM	0.3916 mL	1.9581 mL	3.9163 mL	9.7907 mL
	20 mM	0.2937 mL	1.4686 mL	2.9372 mL	7.3430 mL
	25 mM	0.2350 mL	1.1749 mL	2.3498 mL	5.8744 mL
	30 mM	0.1958 mL	0.9791 mL	1.9581 mL	4.8953 mL
	40 mM	0.1469 mL	0.7343 mL	1.4686 mL	3.6715 mL
	50 mM	0.1175 mL	0.5874 mL	1.1749 mL	2.9372 mL
	60 mM	0.0979 mL	0.4895 mL	0.9791 mL	2.4477 mL
	80 mM	0.0734 mL	0.3672 mL	0.7343 mL	1.8358 mL
	100 mM	0.0587 mL	0.2937 mL	0.5874 mL	1.4686 mL

Tempone Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tempone2896-70-04-Oxo-TempoOthersFree radicalsMRIcontrast agentsacute kidney failureInhibitorinhibitorinhibit

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