Tepilamide fumarate (Synonyms: XP-23829; PPC-06)

Name: Tepilamide fumarate
Brand: MedChemExpress
SKU: HY-109105
Rating: 4.5 (1 reviews)

Cat. No.: HY-109105 Purity: 99.77%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tepilamide fumarate (XP-23829; PPC-06) is an oral fumaric acid ester, acts as a proagent of Monomethyl fumarate (HY-103252), and is used in the research of moderate to severe chronic plaque psoriasis. Tepilamide fumarate can enhance the effectiveness of oncolytic viruses.

For research use only. We do not sell to patients.

Tepilamide fumarate Chemical Structure

CAS No. : 1208229-58-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 220	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 220	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 670	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1050	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1600	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

In Vitro

Tepilamide fumarate (0-200 μM, 4 h) makes 786-0 cancer cells more susceptible to infection by VSV∆51, leading to increased virus replication^[2].
Tepilamide fumarate selectively promotes oncolytic virus infection in cancer cells without affecting healthy tissues^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[2]

Cell Line:	786-0
Concentration:	0, 100, 150, 200 μM
Incubation Time:	4 h
Result:	Increased VSV∆51 infection in cells.

Cell Viability Assay^[2]

Cell Line:	786-0 (virus)
Concentration:	0, 100, 150, 200 μM
Incubation Time:	4 h
Result:	Enhanced viral growth in a dose-dependent manner.

Clinical Trial

Molecular Weight

243.26

Formula

C₁₁H₁₇NO₅

CAS No.

1208229-58-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(N(CC)CC)=O)/C=C/C(OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL (513.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (205.54 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1108 mL	20.5541 mL	41.1083 mL
5 mM	0.8222 mL	4.1108 mL	8.2217 mL
10 mM	0.4111 mL	2.0554 mL	4.1108 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (102.77 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.77%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (243 KB) HNMR (195 KB) LCMS (132 KB)

Handling Instructions (2659 KB)

References

[1]. Mrowietz U, et al. Tepilamide Fumarate (PPC-06) Extended Release Tablets in Patients with Moderate-to-Severe Plaque Psoriasis: Safety and Efficacy Results from the Randomized, Double-blind, Placebo-controlled AFFIRM Study. J Clin Aesthet Dermatol. 2022 Jan;15(1):53-58. [Content Brief]

[2]. Akram Alwithenani, et al. Tepilamide Fumarate as a Novel Potentiator of Virus-Based Therapy. Viruses. 2024 Jun 5;16(6):920. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.1108 mL	20.5541 mL	41.1083 mL	102.7707 mL
	5 mM	0.8222 mL	4.1108 mL	8.2217 mL	20.5541 mL
	10 mM	0.4111 mL	2.0554 mL	4.1108 mL	10.2771 mL
	15 mM	0.2741 mL	1.3703 mL	2.7406 mL	6.8514 mL
	20 mM	0.2055 mL	1.0277 mL	2.0554 mL	5.1385 mL
	25 mM	0.1644 mL	0.8222 mL	1.6443 mL	4.1108 mL
	30 mM	0.1370 mL	0.6851 mL	1.3703 mL	3.4257 mL
	40 mM	0.1028 mL	0.5139 mL	1.0277 mL	2.5693 mL
	50 mM	0.0822 mL	0.4111 mL	0.8222 mL	2.0554 mL
	60 mM	0.0685 mL	0.3426 mL	0.6851 mL	1.7128 mL
	80 mM	0.0514 mL	0.2569 mL	0.5139 mL	1.2846 mL
	100 mM	0.0411 mL	0.2055 mL	0.4111 mL	1.0277 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Tepilamide fumarate Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tepilamide1208229-58-6XP-23829 PPC-06XP23829XP 23829PPC06PPC 06PPC-06OthersVirus replicationpsoriasisfumaric acid esterInhibitorinhibitorinhibit

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Tepilamide fumarate (Synonyms: XP-23829; PPC-06)

Customer Review

Tepilamide fumarate Related Antibodies

Featured Recommendations

•Related Screening Libraries:

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Biological Activity

Purity & Documentation

References

Customer Review

Tepilamide fumarate Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

Tepilamide fumarate Related Classifications

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