2. Protein Tyrosine Kinase/RTK GPCR/G Protein
  3. IGF-1R TSH Receptor
  4. Teprotumumab

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.

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CAS No. : 1036734-93-6

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Teprotumumab Related Antibodies

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Description

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Teprotumumab Related Antibodies
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Teprotumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Teprotumumab on AHC2 biosensor, can bind IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78142) with an affinity constant of 4.315E-10 M as determined in BLI assay.
Purity & Documentation
References
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Teprotumumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Teprotumumab1036734-93-6IGF-1RTSH ReceptorInsulin-like growth factor-1 receptorThyrotropin receptorThyroid-stimulating hormone Receptorthyroid-associated ophthalmopathyTAOfibrocytesInhibitorinhibitorinhibit

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