2. Protein Tyrosine Kinase/RTK GPCR/G Protein
  3. IGF-1R TSH Receptor
  4. Teprotumumab

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.

For research use only. We do not sell to patients.

CAS No. : 1036734-93-6

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Description

Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species

Human
In Vitro

Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH in fibrocytes. IGF-1R and TSHR mRNA abundance is unaffected by Teprotumumab after 24 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

145640.00

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Teprotumumab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Loaded Teprotumumab on AHC2 biosensor, can bind IGF-I R Protein, Human (Biotinylated, HEK293, His-Avi, HY-P78142) with an affinity constant of 4.315E-10 M as determined in BLI assay.
Purity & Documentation
References
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Teprotumumab Related Classifications

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Keywords:

Teprotumumab1036734-93-6IGF-1RTSH ReceptorInsulin-like growth factor-1 receptorThyrotropin receptorThyroid-stimulating hormone Receptorthyroid-associated ophthalmopathyTAOfibrocytesInhibitorinhibitorinhibit

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