2. PROTAC Autophagy Apoptosis
  3. Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis
  4. Thalidomide-d4

Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

For research use only. We do not sell to patients.

Thalidomide-d<sub>4</sub> Chemical Structure

Thalidomide-d4 Chemical Structure

CAS No. : 1219177-18-0

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500 μg USD 280 In-stock
1 mg USD 460 In-stock
5 mg USD 1015 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-d4:

Thalidomide-d4 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

  • Biological Activity

  • Purity & Documentation

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Description

Thalidomide-d4 is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

IC50 & Target

Cereblon

 

Molecular Weight

262.25

Formula

C13H6D4N2O4
CAS No.
Unlabeled CAS

50-35-1
Appearance

Solid

Color

White to off-white

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C([2H])=C([2H])C([2H])=C3[2H])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 12 mg/mL (45.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 12 mg/mL (45.76 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 12 mg/mL (45.76 mM)

DMF : ≥ 12 mg/mL (45.76 mM)

DMSO:PBS (pH 7.2) (1:1) : ≥ 0.11 mg/mL (0.42 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8132 mL 19.0658 mL 38.1316 mL
5 mM 0.7626 mL 3.8132 mL 7.6263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO / DMF / DMF 1 mM 3.8132 mL 19.0658 mL 38.1316 mL 95.3289 mL
5 mM 0.7626 mL 3.8132 mL 7.6263 mL 19.0658 mL
10 mM 0.3813 mL 1.9066 mL 3.8132 mL 9.5329 mL
15 mM 0.2542 mL 1.2711 mL 2.5421 mL 6.3553 mL
20 mM 0.1907 mL 0.9533 mL 1.9066 mL 4.7664 mL
25 mM 0.1525 mL 0.7626 mL 1.5253 mL 3.8132 mL
30 mM 0.1271 mL 0.6355 mL 1.2711 mL 3.1776 mL
40 mM 0.0953 mL 0.4766 mL 0.9533 mL 2.3832 mL
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Thalidomide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-d41219177-18-0Molecular GluesLigands for E3 LigaseAutophagyApoptosisE3 ligase-recruiting MoietyDeuteriumlabeledcereblonCUL4-RBX1-DDB1immunomodulatoryanti-inflammatoryanti-angiogeniccancerInhibitorinhibitorinhibit

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