Thalidomide-Piperazine-PEG2-NH2 diTFA

Name: Thalidomide-Piperazine-PEG2-NH2 diTFA
Brand: MedChemExpress
SKU: HY-138788A
Rating: 4.5 (1 reviews)

Cat. No.: HY-138788A Purity: 99.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-Piperazine-PEG2-NH2 diTFA Chemical Structure

Size	Price	Stock	Quantity
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1650	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Thalidomide-Piperazine-PEG2-NH2 diTFA:

Thalidomide-Piperazine-PEG2-NH2 Get quote

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•Related Small Molecules:

•Related Proteins:

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Biological Activity
Purity & Documentation
References
Customer Review

Description

Thalidomide-Piperazine-PEG2-NH2 diTFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology^[1].

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

701.57

Formula

C₂₇H₃₃F₆N₅O₁₀

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CCN(CCOCCOCCN)CC4)=C3)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (71.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4254 mL	7.1269 mL	14.2537 mL
5 mM	0.2851 mL	1.4254 mL	2.8507 mL
10 mM	0.1425 mL	0.7127 mL	1.4254 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (248 KB) LCMS (98 KB)

Handling Instructions (2659 KB)

References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-999. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4254 mL	7.1269 mL	14.2537 mL	35.6344 mL
	5 mM	0.2851 mL	1.4254 mL	2.8507 mL	7.1269 mL
	10 mM	0.1425 mL	0.7127 mL	1.4254 mL	3.5634 mL
	15 mM	0.0950 mL	0.4751 mL	0.9502 mL	2.3756 mL
	20 mM	0.0713 mL	0.3563 mL	0.7127 mL	1.7817 mL
	25 mM	0.0570 mL	0.2851 mL	0.5701 mL	1.4254 mL
	30 mM	0.0475 mL	0.2376 mL	0.4751 mL	1.1878 mL
	40 mM	0.0356 mL	0.1782 mL	0.3563 mL	0.8909 mL
	50 mM	0.0285 mL	0.1425 mL	0.2851 mL	0.7127 mL
	60 mM	0.0238 mL	0.1188 mL	0.2376 mL	0.5939 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.