Chrysin 6-C-glucoside 8-C-arabinoside

Name: Chrysin 6-C-glucoside 8-C-arabinoside
Brand: MedChemExpress
SKU: HY-120294
Rating: 4.5 (1 reviews)

Cat. No.: HY-120294 Purity: 99.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research.

For research use only. We do not sell to patients.

Chrysin 6-C-glucoside 8-C-arabinoside Chemical Structure

CAS No. : 185145-34-0

Size	Price	Stock	Quantity
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 800	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Chrysin 6-C-glucoside 8-C-arabinoside can inhibit the CGRP releasing and the activation of TRPV1 channel. Chrysin 6-C-glucoside 8-C-arabinoside can be used for anti-migraine research^[1].

IC₅₀ & Target

TRPV1

Molecular Weight

548.49

Formula

C₂₆H₂₈O₁₃

CAS No.

185145-34-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C2=C(O)C([C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C(O)C([C@@H]4OC[C@H](O)[C@H](O)[C@H]4O)=C2OC(C5=CC=CC=C5)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (182.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8232 mL	9.1159 mL	18.2319 mL
5 mM	0.3646 mL	1.8232 mL	3.6464 mL
10 mM	0.1823 mL	0.9116 mL	1.8232 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (4.56 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (297 KB) SDS (252 KB)

COA (259 KB) HNMR (118 KB) CNMR (117 KB) RP-HPLC (208 KB)

Handling Instructions (2659 KB)

References

[1]. Zheng G, et al. Screen of anti-migraine active compounds from Duijinsan by spectrum-effect relationship analysis and molecular docking. J Ethnopharmacol. 2021 Oct 28;279:114352. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8232 mL	9.1159 mL	18.2319 mL	45.5797 mL
	5 mM	0.3646 mL	1.8232 mL	3.6464 mL	9.1159 mL
	10 mM	0.1823 mL	0.9116 mL	1.8232 mL	4.5580 mL
	15 mM	0.1215 mL	0.6077 mL	1.2155 mL	3.0386 mL
	20 mM	0.0912 mL	0.4558 mL	0.9116 mL	2.2790 mL
	25 mM	0.0729 mL	0.3646 mL	0.7293 mL	1.8232 mL
	30 mM	0.0608 mL	0.3039 mL	0.6077 mL	1.5193 mL
	40 mM	0.0456 mL	0.2279 mL	0.4558 mL	1.1395 mL
	50 mM	0.0365 mL	0.1823 mL	0.3646 mL	0.9116 mL
	60 mM	0.0304 mL	0.1519 mL	0.3039 mL	0.7597 mL
	80 mM	0.0228 mL	0.1139 mL	0.2279 mL	0.5697 mL
	100 mM	0.0182 mL	0.0912 mL	0.1823 mL	0.4558 mL