2. Cell Cycle/DNA Damage Apoptosis Metabolic Enzyme/Protease
  3. Topoisomerase Apoptosis Bcl-2 Family Cytochrome P450
  4. Thaspine acetate

Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri.

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Thaspine acetate Chemical Structure

Thaspine acetate Chemical Structure

CAS No. : 74578-01-1

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Other Forms of Thaspine acetate:

Thaspine acetate Related Antibodies

Top Publications Citing Use of Products

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Topoisomerase Topo I Topo II

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri[1].

IC50 & Target[1]

Topoisomerase I

 

Topoisomerase II

 

Bax

 

Bak

 

Molecular Weight

429.42

Formula

C22H23NO8
CAS No.
SMILES

O=C1C2=CC=C(OC)C(O3)=C2C4=C(C3=O)C(CCN(C)C)=CC(OC)=C4O1.CC(O)=O
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Purity & Documentation
References
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Thaspine acetate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thaspine74578-01-1TopoisomeraseApoptosisBcl-2 FamilyCytochrome P450CYPscolon carcinomaHCT-116anticancerInhibitorinhibitorinhibit

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