2. Membrane Transporter/Ion Channel
  3. P2X Receptor
  4. Taspine

Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage.

For research use only. We do not sell to patients.

Taspine Chemical Structure

Taspine Chemical Structure

CAS No. : 602-07-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Taspine:

Taspine Related Antibodies

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Description

Taspine is a natural product with anti-inflammatory activity. Taspine suppresses P2X4 receptor activity via PI3K inhibition. Taspine inhibits pro-inflammatory signalling via inhibition of P2X4 receptors in macrophage[1].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
11.2 μM
Compound: 1
Antiproliferative activity against human A431 cells abnormally expressing EGFR after 48 hrs by MTT assay
Antiproliferative activity against human A431 cells abnormally expressing EGFR after 48 hrs by MTT assay
[PMID: 20304537]
A549 IC50
4.18 μM
Compound: 1
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
[PMID: 20304537]
Caco-2 IC50
153 μM
Compound: 1
Antiproliferative activity against human Caco-2 cells after 48 hrs by MTT assay
Antiproliferative activity against human Caco-2 cells after 48 hrs by MTT assay
[PMID: 20304537]
ECV-304 IC50
22.3 μM
Compound: 1
Antiproliferative activity against human ECV304 cells after 48 hrs by MTT assay
Antiproliferative activity against human ECV304 cells after 48 hrs by MTT assay
[PMID: 20304537]
HEK293 IC50
15.95 μM
Compound: 1
Antiproliferative activity against human HEK293 cells overexpressing EGFR after 48 hrs by MTT assay
Antiproliferative activity against human HEK293 cells overexpressing EGFR after 48 hrs by MTT assay
[PMID: 20304537]
Molecular Weight

369.37

Formula

C20H19NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=C(OC)C(O3)=C2C4=C(C3=O)C(CCN(C)C)=CC(OC)=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Taspine Related Classifications

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The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taspine602-07-3P2X ReceptorP2XRsP2X receptorion channelnatural productpurinergicanti-inflammatoryPI3K inhibitionInhibitorinhibitorinhibit

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HY-131502
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