Thio-ITP  (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I K_i: 40.9 μM; RNA polymerase II K_i: 38.0 μM)^[1].

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

524.23

C₁₀H₁₅N₄O₁₃P₃S

27652-34-2

O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(O)(O)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=CN3)=S)N=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.  [Content Brief]