2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Thio-ITP

Thio-ITP  (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5'-triphosphate; 6-Thio-ITP)

Cat. No.: HY-115755
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Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM).

For research use only. We do not sell to patients.

Thio-ITP Chemical Structure

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

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Thio-ITP Related Antibodies

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Description

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

In Vitro

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thio-ITP Related Antibodies
Molecular Weight

524.23

Formula

C10H15N4O13P3S
CAS No.
SMILES

O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP(OP(O)(O)=O)(O)=O)(O)=O)([H])N2C3=C(C(N=CN3)=S)N=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thio-ITP Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thio-ITP27652-34-26-Thioinosine 5′-triphosphate 6-Mercaptopurine-riboside-5'-triphosphate 6-Thio-ITPDNA/RNA SynthesisP3HR-1lymphoma cellspolymeraseRNADNA-directed RNA synthesisInhibitorinhibitorinhibit

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