Timolol hemihydrate  (Synonyms: (S)-L-714,465 hemihydrate; MK 950 hemihydrate)

Timolol (hemihydrate) is a β-blocker available for both topical and systemic administration. Timolol (hemihydrate) is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension and Timolol (hemihydrate) also has cardioprotective effect^[1][2].

Timolol (hemihydrate) can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol (hemihydrate) can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Timolol (hemihydrate) (5 mg/kg daily for 12-week) has a cardioprotective effect via inhibition of ERS response in diabetic rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

325.43

C₁₃H₂₄N₄O₃S.1/2H₃O

91524-16-2

O[C@@H](CNC(C)(C)C)COC1=NSN=C1N2CCOCC2.[1/2H2O]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Figen Amber Cicek, et al. Beta-blocker timolol alleviates hyperglycemia-induced cardiac damage via inhibition of endoplasmic reticulum stress. J Bioenerg Biomembr  [Content Brief]

  [2]. E. Ansari, et al. Treatment of open-angle glaucoma and ocular hypertension with preservative-free tafuprost/timolol fxed-dose combination therapy: 6 case reports and clinical outcomes. BMC Ophthalmol. 2022 Apr 2;22(1):152.  [Content Brief]