2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Timolol

Timolol  (Synonyms: (S)-L-714,465; MK 950 free base)

Cat. No.: HY-17494
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Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form ((S)-Timolol maleate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Timolol Chemical Structure

Timolol Chemical Structure

CAS No. : 26839-75-8

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Timolol Related Antibodies

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Description

Timolol is a β-blocker available for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

IC50 & Target

β adrenergic receptor

 

In Vitro

Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Timolol Related Antibodies
In Vivo

Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Experimental diabetes model: 3-month old male Wistar rats[3].
Dosage: 5 mg/kg
Administration: Timolol (5 mg/kg daily for 12-week)
Result: Showed cardioprotective effect.
Clinical Trial
Molecular Weight

316.42

Formula

C13H24N4O3S
CAS No.
SMILES

O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Timolol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Timolol26839-75-8(S)-L-714,465MK 950MK950MK-950Adrenergic ReceptorBeta Receptorβ-blockeropen-angle glaucomaocular hypertensioninfantile hemangiomashypertensionmyocardial infarctionmigraine prophylaxisatrial fibrillationInhibitorinhibitorinhibit

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