2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR8 agonist 9

TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 9 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 97%.

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TLR8 agonist 9 Chemical Structure

TLR8 agonist 9 Chemical Structure

CAS No. : 3034750-61-0

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TLR8 agonist 9 Related Antibodies

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Description

TLR8 agonist 9 (Compound II-77) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 9 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 9 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 97%[1].

IC50 & Target

TLR8

 

Molecular Weight

725.79

Formula

C38H43N7O8
CAS No.
SMILES

O=C(C=CC1=O)N1CC2OCC(C(N3CCC4=NC=C(NC(C5(CC5)C6=CC=C7C(N=C(N)CC(C(N(CCC)CCO)=O)=C7)=C6)=O)C=C4C3)=O)CO2
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References
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TLR8 agonist 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR8 agonist 93034750-61-0Toll-like Receptor (TLR)BT474MCF-7MDA-AB-468NUGC-4MDA-AB-175VIILS180AsPC-1MC38-HER2colon cancerInhibitorinhibitorinhibit

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