TNAP-IN-1

Cat. No.: HY-14210 Purity: 98.56%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

TNAP-IN-1 (Compound 1) is a selective tissue-nonspecific alkaline phosphatase (TNAP) inhibitor, with an IC₅₀ of 0.19 μM. TNAP-IN-1 can be used for the research of soft tissue calcification.

For research use only. We do not sell to patients.

TNAP-IN-1 Chemical Structure

CAS No. : 496014-13-2

Size	Price	Stock	Quantity
5 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 340	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
COS-1	IC₅₀	0.19 μM Compound: 1, pubchem CID 2931238	Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay Inhibition of TNAP transfected in african green monkey COS1 cells by colorimetric assay	[PMID: 19821572]

Molecular Weight

344.38

Formula

C₁₇H₁₆N₂O₄S

CAS No.

496014-13-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=S(NC1=CN=C2C=CC=CC2=C1)(C3=CC(OC)=CC=C3OC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (145.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9038 mL	14.5188 mL	29.0377 mL
5 mM	0.5808 mL	2.9038 mL	5.8075 mL
10 mM	0.2904 mL	1.4519 mL	2.9038 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.56%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (249 KB) HNMR (254 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Dahl R, et al. Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP). J Med Chem. 2009 Nov 12;52(21):6919-25. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9038 mL	14.5188 mL	29.0377 mL	72.5942 mL
	5 mM	0.5808 mL	2.9038 mL	5.8075 mL	14.5188 mL
	10 mM	0.2904 mL	1.4519 mL	2.9038 mL	7.2594 mL
	15 mM	0.1936 mL	0.9679 mL	1.9358 mL	4.8396 mL
	20 mM	0.1452 mL	0.7259 mL	1.4519 mL	3.6297 mL
	25 mM	0.1162 mL	0.5808 mL	1.1615 mL	2.9038 mL
	30 mM	0.0968 mL	0.4840 mL	0.9679 mL	2.4198 mL
	40 mM	0.0726 mL	0.3630 mL	0.7259 mL	1.8149 mL
	50 mM	0.0581 mL	0.2904 mL	0.5808 mL	1.4519 mL
	60 mM	0.0484 mL	0.2420 mL	0.4840 mL	1.2099 mL
	80 mM	0.0363 mL	0.1815 mL	0.3630 mL	0.9074 mL
	100 mM	0.0290 mL	0.1452 mL	0.2904 mL	0.7259 mL

TNAP-IN-1 Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNAP-IN-1496014-13-2Phosphatasesoft tissuecalcificationInhibitorinhibitorinhibit

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