1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Topoisomerase I inhibitor 12

Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity.

For research use only. We do not sell to patients.

Topoisomerase I inhibitor 12 Chemical Structure

Topoisomerase I inhibitor 12 Chemical Structure

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Description

Topoisomerase I inhibitor 12 (compound 12), a Camptothecin (HY-16560)-based derivative, is a potent Topoisomerase I inhibitor. Topoisomerase I inhibitor 12 shows anticancer activity[1].

IC50 & Target

Topoisomerase I

 

In Vitro

Topoisomerase I inhibitor 12 (compound 12) shows moderate antiproliferative activity against the MDA-MB-231, DU-145, HCT-116, SKOV-3, and SAOS-2 cancer cell lines (with IC50 values of 5.96±0.03, 3.81±1.37, 3.67±0.21, 3.48±1.02, and 3.20±0.21 µM, respectively), as well as potent activity against the HOS (osteosarcoma) cancer cell line (IC50=1.47 µM) while the potential of Topoisomerase I inhibitor 12 against fibroblast normal cells (BJ1) demonstrated a 2.89-fold selectivity (IC50=4.25 µM) against cancer cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

402.45

Formula

C23H22N4O3

SMILES

O=C1N2C(N(CCN3CCOCC3)C(/C2=C\C4=CC=CC=C4)=O)=NC5=CC=CC=C51

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Topoisomerase I inhibitor 12
Cat. No.:
HY-161082
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