Camptothecin (Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT)

Name: Camptothecin
Brand: MedChemExpress
SKU: HY-16560
Rating: 5.0 (43 reviews)

Cat. No.: HY-16560 Purity: 99.86%: FAQs
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Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells.

For research use only. We do not sell to patients.

Camptothecin Chemical Structure

CAS No. : 7689-03-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 61	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 61	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
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Based on 43 publication(s) in Google Scholar

Other Forms of Camptothecin:

(R)-Camptothecin Get quote
Camptothecin-d₅ Get quote

39 Publications Citing Use of MCE Camptothecin

Cell Viability Assay

: Camptothecin purchased from MedChemExpress. Usage Cited in: Arch Cancer Res. 2023 Jan 30.; Camptothecin (CPT; 10^-5 -10^-10 M; 72 h) demonstrates a strong antitumor activity and an inhibitory of proliferation (IC₅₀ = 25.36 nM) in U937 cells.

: Camptothecin purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2020 Nov;27(11):3162-3176. [Abstract]; 293T cells transfected with Flag-TopBP1 and GFP-tagged RBMX and its domain (RRM, RBM1CTR, and C-RBD) are treated with 100 nM CPT for 24 h and subjected to immunoprecipitation with Flag-beads. Immunoprecipitates are immunoblotted with Flag and GFP antibodies, respectively.

: Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 21;10(1):3761. [Abstract]; Genotoxic stress-induced β-catenin signaling is activated via a TCF- or FOXO-independent mechanism. Representative images of the subcellular localization of β-catenin in the indicated cells treated with CPT (10 μM, 1 h), IR (10 Gy), and CDDP (10 μM, 1 h), as analyzed by immunofluorescence staining.

: Camptothecin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2018 Oct 8;9(1):4139. [Abstract]; One hour after treated with UV or 2 h after treated with MMS, Camptothecin (CPT) (10 μM), or Doxorubicin (DOX; 0.5 μM), HEK293T cells expressing HA-SUMO2 and His-RhoB are subjected to sumoylation assay to detect the SUMO2 conjugation of RhoB.

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Biological Activity
Purity & Documentation
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Description

Camptothecin (CPT), a kind of alkaloid, is a DNA topoisomerase I (Topo I) inhibitor with an IC₅₀ of 679 nM^[1]. Camptothecin (CPT) exhibits powerful antineoplastic activity against colorectal, breast, lung and ovarian cancers, modulates hypoxia-inducible factor-1α (HIF-1α) activity by changing microRNAs (miRNA) expression patterns in human cancer cells^[2]^[3].

IC₅₀ & Target^[3]

Topoisomerase I

679 nM (IC₅₀)

Camptothecins

Cellular Effect

Cell Line	Type	Value	Description	References
184B5	IC₅₀	4.96 μM Compound: Camptothecin	Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay Antiproliferative activity against human 184B5 cells after 72 hrs by SRB assay	[PMID: 26602827]
1A9	ED₅₀	3.2 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human 1A9 cells by sulforhodamine B assay Cytotoxicity against human 1A9 cells by sulforhodamine B assay	[PMID: 17350834]
4T1	IC₅₀	0.17 μM Compound: 1; CPT	Antiproliferative activity against mouse 4T1 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
786-0	IC₅₀	0.015 μM Compound: CPT	Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay Antiproliferative activity against human 786-O cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
A2780	IC₅₀	0.004 μM Compound: camptothecin	Cytotoxicity against human A2780 cells after 72 hrs by MTS method Cytotoxicity against human A2780 cells after 72 hrs by MTS method	[PMID: 11858737]
A2780	IC₅₀	0.029 μM Compound: 1; CPT	Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay Antiproliferative activity against human A2780 cells after 96 hrs by MTT assay	[PMID: 27871039]
A2780	IC₅₀	0.07 μg/mL Compound: camptothecin	Cytotoxicity against human A2780 cells by clonogenic assay Cytotoxicity against human A2780 cells by clonogenic assay	[PMID: 16499333]
A2780	IC₅₀	0.2 μM Compound: camptothecin	Cytotoxicity against human A2780 cells after 24 hrs by MTT assay Cytotoxicity against human A2780 cells after 24 hrs by MTT assay	[PMID: 20961093]
A2780	IC₅₀	0.2 μM Compound: 1, CPT	Cytotoxicity against human A2780 cells after 4 days by MTT assay Cytotoxicity against human A2780 cells after 4 days by MTT assay	[PMID: 18554906]
A2780	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 22044245]
A2780	IC₅₀	0.28 μM Compound: Camptothecin	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 19453174]
A2780	IC₅₀	0.28 μM Compound: camptothecin	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 18095653]
A2780	IC₅₀	0.3 μM Compound: CPT	Cytotoxicity against human A2780 cells after 4 days by MTT assay Cytotoxicity against human A2780 cells after 4 days by MTT assay	[PMID: 19702283]
A2780	IC₅₀	0.3 μM Compound: camptothecin	Cytotoxicity against human A2780 cells after 96 hrs by MTT assay Cytotoxicity against human A2780 cells after 96 hrs by MTT assay	[PMID: 19256478]
A2780	GI₅₀	0.46 μM Compound: CPT	Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human A2780 cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
A2780	IC₅₀	0.9 μM Compound: camptothecin	Cytotoxicity against human A2780 cells by MTT assay Cytotoxicity against human A2780 cells by MTT assay	[PMID: 25237727]
A2780	IC₅₀	13 nM Compound: CPT	Cytotoxicity against human A2780 cells after 72 hrs by MTT assay Cytotoxicity against human A2780 cells after 72 hrs by MTT assay	[PMID: 24900725]
A2780	IC₅₀	7 nM Compound: Cpt	Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A2780 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
A-375	IC₅₀	0.013 μM Compound: Camptothecin	Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A-375	IC₅₀	0.187 μM Compound: CPT, Camptothecin	Cytotoxicity against human A375 cells after 24 hrs by MTT assay Cytotoxicity against human A375 cells after 24 hrs by MTT assay	[PMID: 24980118]
A-375	IC₅₀	0.66 μM Compound: CPT	Cytotoxicity against human A-375 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human A-375 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
A-431	IC₅₀	0.011 μM Compound: 1, CPT	Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay Cytotoxicity against human A431 cells after 72 hrs by trypan blue assay	[PMID: 21071230]
A549	IC₅₀	< 0.01 μM Compound: Camptothecin	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 24180210]
A549	IC₅₀	< 1 μM Compound: CPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28511910]
A549	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
A549	GI₅₀	0.003 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
A549	IC₅₀	0.004 μM Compound: camptothecin	Cytotoxicity against human A549 cells after 48 hrs Cytotoxicity against human A549 cells after 48 hrs	[PMID: 17673337]
A549	IC₅₀	0.006 μM Compound: 1; CPT	Antiproliferative activity against human A549 cells after 96 hrs by MTT assay Antiproliferative activity against human A549 cells after 96 hrs by MTT assay	[PMID: 27871039]
A549	GI₅₀	0.007 μM Compound: Camptothecin	Growth inhibition of human A549 cells after 48 hrs by MTT assay Growth inhibition of human A549 cells after 48 hrs by MTT assay	[PMID: 23357037]
A549	IC₅₀	0.008 μM Compound: Camptothecin	Cytotoxicity against human A549 cells after 2 days by MTT assay Cytotoxicity against human A549 cells after 2 days by MTT assay	[PMID: 22325897]
A549	IC₅₀	0.009 μM Compound: Camptothecin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A549	IC₅₀	0.01 μM Compound: 1, CPT	Cytotoxicity against human A549 cells after 4 days by MTT assay Cytotoxicity against human A549 cells after 4 days by MTT assay	[PMID: 18554906]
A549	GI₅₀	0.01 μM Compound: 1, CPT	Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
A549	IC₅₀	0.0158 μM Compound: 1, CPT	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 23102893]
A549	IC₅₀	0.016 μM Compound: 1, CPT	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 25003995]
A549	IC₅₀	0.016 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B colorimetric assay	[PMID: 26994847]
A549	IC₅₀	0.03 μM Compound: Camptothecin	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 31546197]
A549	IC₅₀	0.03 μM Compound: Camptothecin	Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human A549 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
A549	IC₅₀	0.039 μM Compound: CPT	Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
A549	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 30543429]
A549	IC₅₀	0.04 μM Compound: 1, CPT	Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human A549 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
A549	IC₅₀	0.047 μM Compound: 1, CPT	Antitumor activity against human A549/ATCC cells by SRB method Antitumor activity against human A549/ATCC cells by SRB method	[PMID: 19541483]
A549	IC₅₀	0.057 μM Compound: CPT	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 20942490]
A549	IC₅₀	0.058 μM Compound: CPT	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 19345580]
A549	IC₅₀	0.067 μM Compound: CPT, campothecin	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17827007]
A549	IC₅₀	0.069 μM Compound: CPT	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21353568]
A549	IC₅₀	0.069 μM Compound: camptothecin	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17498951]
A549	IC₅₀	0.072 μg/mL Compound: CPT	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 21684168]
A549	IC₅₀	0.074 μM Compound: CPT	In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human A549 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
A549	IC₅₀	0.09 μM Compound: CPT; 1	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 30509782]
A549	IC₅₀	0.091 μM Compound: CPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21873069]
A549	GI₅₀	0.099 μM Compound: CPT	Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay Growth inhibition of human A549 cells incubated for 72 hrs by MTT assay	[PMID: 31176097]
A549	IC₅₀	0.1 μM Compound: 1; CPT	Antiproliferative activity against human A549 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
A549	IC₅₀	0.1 μM Compound: CPT	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 26226379]
A549	IC₅₀	0.12 μM Compound: Camptothecin	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 27344492]
A549	IC₅₀	0.17 μM Compound: CPT	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 34052678]
A549	GI₅₀	0.17 μM Compound: 1, CPT	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
A549	GI₅₀	0.2 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21388138]
A549	GI₅₀	0.21 μM Compound: 1	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 30336023]
A549	IC₅₀	0.24 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28063351]
A549	IC₅₀	0.26 μM Compound: CPT	Antiproliferative activity against human A549 cells after 72 hrs by MTT assay Antiproliferative activity against human A549 cells after 72 hrs by MTT assay	[PMID: 28351590]
A549	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 22044245]
A549	GI₅₀	0.31 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 34008967]
A549	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay Cytotoxicity against human A549 cells after 48 hrs by CCK8 assay	[PMID: 30702286]
A549	IC₅₀	0.35 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 96 hrs by MTT assay	[PMID: 27156772]
A549	IC₅₀	0.37 μM Compound: CPT	Cytotoxicity against human A549 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human A549 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
A549	IC₅₀	0.46 μM Compound: 1; CPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 27416553]
A549	IC₅₀	0.47 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35635947]
A549	IC₅₀	0.65 μM Compound: 1, CPT	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 24069881]
A549	IC₅₀	0.7 μM Compound: Camptothecin	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 28506750]
A549	IC₅₀	1 nM Compound: CPT	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis	[PMID: 34952177]
A549	IC₅₀	1 nM Compound: CPT	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 33962152]
A549	IC₅₀	1 nM Compound: I; CPT	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 31229877]
A549	IC₅₀	1 nM Compound: CPT	Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human A549 cells after 48 hrs by CCK-8 assay	[PMID: 29501943]
A549	IC₅₀	1 nM Compound: Camptothecin	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by CCK8 assay	[PMID: 27017547]
A549	IC₅₀	1 nM Compound: camptothecin	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 25237727]
A549	IC₅₀	1 μM Compound: I; CPT	Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay	[PMID: 32279049]
A549	IC₅₀	1.3 μM Compound: 3	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 25084144]
A549	IC₅₀	1.31 μM Compound: CPT	Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against against human A549 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
A549	IC₅₀	1.56 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
A549	IC₅₀	1.6 μM Compound: CPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 26188908]
A549	IC₅₀	13.64 μM Compound: Camptothecin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28462840]
A549	IC₅₀	2.21 μM Compound: Camptothecin	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 30109008]
A549	IC₅₀	2.53 μM Compound: Camptothecin	In vitro antiproliferative activity of compound against AS-49 (human lung caner ) cell line was determined by SRB assay In vitro antiproliferative activity of compound against AS-49 (human lung caner ) cell line was determined by SRB assay	[PMID: 12639541]
A549	IC₅₀	2.61 μM Compound: CPT	Antiproliferative activity against human A549 cells after 3 days by MTT assay Antiproliferative activity against human A549 cells after 3 days by MTT assay	[PMID: 23084702]
A549	IC₅₀	2.8 μM Compound: CPT	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
A549	GI₅₀	2.8 μM Compound: CPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20662543]
A549	GI₅₀	2.8 μM Compound: 1, camptothecin	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 18180162]
A549	IC₅₀	26.45 μM Compound: CPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 25599951]
A549	IC₅₀	3.1 μM Compound: camptothecin	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 19256478]
A549	IC₅₀	3.12 μM Compound: camptothecin	Cytotoxicity against human A549 cells after 96 hrs by MTT assay Cytotoxicity against human A549 cells after 96 hrs by MTT assay	[PMID: 18095653]
A549	IC₅₀	3.32 μM Compound: Camptothecin	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 30902399]
A549	IC₅₀	3.6 μM Compound: camptothecin	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 20961093]
A549	IC₅₀	32.11 μM Compound: CPT	Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay	[PMID: 30853330]
A549	IC₅₀	33.8 nM Compound: 1, CPT	Cytotoxicity against human A549 after 72 hrs by SRB assay Cytotoxicity against human A549 after 72 hrs by SRB assay	[PMID: 22647222]
A549	IC₅₀	37.05 μM Compound: Camptothecin	Cytotoxicity against human A549 cells after 72 hrs ny MTT assay Cytotoxicity against human A549 cells after 72 hrs ny MTT assay	[PMID: 23974020]
A549	IC₅₀	4.43 μM Compound: CPT	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 30685528]
A549	IC₅₀	5.379 nM Compound: CPT	Cytotoxicity against human A549 cells after 48 hrs by MTT method Cytotoxicity against human A549 cells after 48 hrs by MTT method	[PMID: 20063889]
A549	IC₅₀	5.5 μM Compound: Camptothecin	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30025344]
A549	IC₅₀	5.93 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28923388]
A549	IC₅₀	5.93 μM Compound: CPT	Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay Cytotoxicity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 27721148]
A549	IC₅₀	50.88 μM Compound: CPT	Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay	[PMID: 30853330]
A549	ED₅₀	6.9 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 17350834]
A549	IC₅₀	67 nM Compound: 1, CPT, NSC-100880	Cytotoxicity against human A549 cells by WST assay Cytotoxicity against human A549 cells by WST assay	[PMID: 23578545]
A549	IC₅₀	67 nM Compound: CPT	Cytotoxicity against A549 tumor cell line determined by WST-1 assay Cytotoxicity against A549 tumor cell line determined by WST-1 assay	[PMID: 10841808]
A549	IC₅₀	8.63 nM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by SRB assay Cytotoxicity against human A549 cells after 72 hrs by SRB assay	[PMID: 28927790]
A549	IC₅₀	8.63 nM Compound: 1; CPT	Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 72 hrs by sulforhodamine B assay	[PMID: 28285912]
A549	IC₅₀	8.87 μM Compound: Camptothecin	Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity in human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 28923382]
A549	IC₅₀	8.9 μM Compound: CPT	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34852457]
A549	IC₅₀	99 nM Compound: CPT	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 24900725]
ADR5000 cell line	IC₅₀	0.011 μM Compound: Camptothecin	Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay	[PMID: 28233677]
ADR5000 cell line	IC₅₀	0.3 μM Compound: CPT	Cytotoxicity against human CEM/ADR5000 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human CEM/ADR5000 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24484281]
AGS	GI₅₀	0.01 μM Compound: 1, CPT	Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
AGS	IC₅₀	0.02 μM Compound: 1, CPT	Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human AGS cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
AGS	GI₅₀	23.76 μM Compound: 1, camptothecin	Antiproliferative activity against human AGS cells after 48 hrs by MTT assay Antiproliferative activity against human AGS cells after 48 hrs by MTT assay	[PMID: 18180162]
AGS	IC₅₀	23.76 μM Compound: CPT	Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay Antiproliferative activity against human AGS cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
B16-F10	IC₅₀	2.78 μM Compound: Camptothecin	Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay Cytotoxicity against mouse B16F10 cells after 48 hrs by MTT assay	[PMID: 24685545]
Bel-7402	IC₅₀	0.014 μM Compound: 1; CPT	Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay Antiproliferative activity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 27871039]
Bel-7402	IC₅₀	0.17 μM Compound: 1, CPT	Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay Cytotoxicity against human BEL-7402 cells after 4 days by MTT assay	[PMID: 18554906]
Bel-7402	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 22044245]
Bel-7402	IC₅₀	12.5 μM Compound: camptothecin	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 19256478]
Bel-7402	IC₅₀	12.5 μM Compound: camptothecin	Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay Cytotoxicity against human Bel7402 cells after 96 hrs by MTT assay	[PMID: 18095653]
Bel-7402	IC₅₀	2.72 μg/mL Compound: 1 Camptothecin	In vitro cytotoxicity against Bel7402 cell line (human liver cancer) using MTT assay In vitro cytotoxicity against Bel7402 cell line (human liver cancer) using MTT assay	[PMID: 15225719]
Bel-7402	IC₅₀	6.3 μM Compound: camptothecin	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 25237727]
BEL-7404 tumor cell line	IC₅₀	0.14 μM Compound: CPT	Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay Cytotoxicity against human Bel7404 cells after 72 hrs by MTT assay	[PMID: 26226379]
BEL-7404 tumor cell line	IC₅₀	0.4 μM Compound: CPT	Antiproliferative activity against human Bel7404 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human Bel7404 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
BGC-823	IC₅₀	0.04 μM Compound: camptothecin	Cytotoxicity against human BGC823 cells by MTT assay Cytotoxicity against human BGC823 cells by MTT assay	[PMID: 25237727]
BGC-823	IC₅₀	0.057 μM Compound: 1; CPT	Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 96 hrs by MTT assay	[PMID: 27871039]
BGC-823	IC₅₀	1.27 μM Compound: 1; CPT	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 27416553]
BGC-823	IC₅₀	9.67 μM Compound: camptothecin	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay	[PMID: 18095653]
BGC-823	IC₅₀	9.7 μM Compound: camptothecin	Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay Cytotoxicity against human BGC823 cells after 96 hrs by MTT assay	[PMID: 19256478]
BJ	IC₅₀	> 40 μM Compound: Camp	Cytotoxicity against human BJ cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human BJ cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
BT-20	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human BT20 cells after 3 days by SRB assay Cytotoxicity against human BT20 cells after 3 days by SRB assay	[PMID: 23142674]
BT-20	IC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay Cytotoxicity against human BT20 cells assessed as growth inhibition after 48 hrs by CCK8 assay	[PMID: 27017547]
BT-20	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay Cytotoxicity against human BT20 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
BT-474	IC₅₀	12.75 μM Compound: CPT	Cytotoxicity against human BT474 cells after 3 days by SRB assay Cytotoxicity against human BT474 cells after 3 days by SRB assay	[PMID: 23142674]
BT-474	IC₅₀	7 μM Compound: Camptothecin	Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay Antiproliferative activity against human BT474 cells after 72 hrs by CCK8 assay	[PMID: 26988802]
BT-483	GI₅₀	1.03 μM Compound: CPT	Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay Cytotoxicity against human BT-483 cells after 48 hrs by MTT assay	[PMID: 20662543]
BXPC-3	IC₅₀	0.24 μM Compound: 1, CPT	Cytotoxicity against human BXPC3 cells after 4 days by MTT assay Cytotoxicity against human BXPC3 cells after 4 days by MTT assay	[PMID: 18554906]
C6	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human C6 cells measured after 72 hrs by MTT assay Antiproliferative activity against human C6 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
CA46	IC₅₀	0.52 μM Compound: CPT	Cytotoxicity against human CA46 cells after 48 hrs by MTT assay Cytotoxicity against human CA46 cells after 48 hrs by MTT assay	[PMID: 26188908]
Caco-2	IC₅₀	0.131 μM Compound: CPT, Camptothecin	Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay Cytotoxicity against human Caco2 cells after 24 hrs by MTT assay	[PMID: 24980118]
Caco-2	IC₅₀	9.55 μM Compound: Camptothecin	Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human Caco2 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 21843907]
CAKI-2	IC₅₀	3.96 μM Compound: Camptothecin	In vitro antiproliferative activity of compound against Caki-2 (human renal caner ) cell line was determined by SRB assay In vitro antiproliferative activity of compound against Caki-2 (human renal caner ) cell line was determined by SRB assay	[PMID: 12639541]
CAMA-1	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human CAMA1 cells after 3 days by SRB assay Cytotoxicity against human CAMA1 cells after 3 days by SRB assay	[PMID: 23142674]
CAMA-1	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay Cytotoxicity against human CAMA1 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
CAPAN-1	IC₅₀	0.21 μM Compound: CPT	Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay Cytotoxicity against human Capan1 cells after 72 hrs by XTT assay	[PMID: 30017114]
Ca-Ski	IC₅₀	1.8 μM Compound: Camptothecin	Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay Antiproliferative activity against human CaSki cells after 24 hrs by crystal violet staining-based assay	[PMID: 29407986]
CCRF-CEM	GI₅₀	0.002 μM Compound: camptothecin	Growth inhibition of human CEM cells by Alamar blue assay Growth inhibition of human CEM cells by Alamar blue assay	[PMID: 17418582]
CCRF-CEM	GI₅₀	0.002 μM Compound: CPT	Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
CCRF-CEM	IC₅₀	0.002 μM Compound: CPT	Cytotoxicity against human CCRF-CEM cells by MTT assay Cytotoxicity against human CCRF-CEM cells by MTT assay	[PMID: 30543429]
CCRF-CEM	CC₅₀	0.003 μM Compound: Camptothecin	Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay	[PMID: 22884523]
CCRF-CEM	CC₅₀	0.003 μM Compound: Camptothecin	Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells after 96 hrs by MTT assay	[PMID: 22047799]
CCRF-CEM	IC₅₀	0.003 μM Compound: CPT	Antiproliferative activity against human CCRF-CEM cells by MTT assay Antiproliferative activity against human CCRF-CEM cells by MTT assay	[PMID: 17254669]
CCRF-CEM	IC₅₀	0.003 μM Compound: Camptothecin	Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by resazurin reduction assay	[PMID: 28233677]
CCRF-CEM	GI₅₀	0.007 μM Compound: 1	Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay Growth inhibition of human CCRF-CEM cells after 72 hrs by MTT assay	[PMID: 30336023]
CCRF-CEM	GI₅₀	0.023 nM Compound: camptothecin	Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay Cytotoxicity against human CCRF-CEM cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
CCRF-CEM	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay Cytotoxicity against p38-proficient human CCRF-CEM cells after 3 days by MTT assay	[PMID: 19203291]
CCRF-CEM	IC₅₀	0.08 μM Compound: CPT	Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24484281]
CCRF-CEM	IC₅₀	0.84 nM Compound: CPT	Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h Inhibitory concentration against CEM cell growth after incubation in liquid medium for 72 h	[PMID: 15916431]
CCRF-CEM	GI₅₀	43.21 nM Compound: camptothecin	Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay Cytotoxicity against human CCRF-CEM/C2 cells after 48 hrs by cell titer-blue assay	[PMID: 19743858]
CCRF-SB	IC₅₀	0.003 μM Compound: CPT	Antiproliferative activity against human CCRF-SB cells by MTT assay Antiproliferative activity against human CCRF-SB cells by MTT assay	[PMID: 17254669]
CCRF-SB	CC₅₀	0.004 μM Compound: Camptothecin	Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay	[PMID: 22884523]
CCRF-SB	CC₅₀	0.004 μM Compound: Camptothecin	Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay Cytotoxicity against human CCRF-SB cells after 96 hrs by MTT assay	[PMID: 22047799]
CEM/C2	GI₅₀	> 1 μM Compound: camptothecin	Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay Growth inhibition of topoisomerase 1 mutated CEM/C2 cells by Alamar blue assay	[PMID: 17418582]
CEM/C2	IC₅₀	5385 nM Compound: CPT	Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h Inhibitory concentration against CEM/C2 cell growth after incubation in liquid medium for 72 h	[PMID: 15916431]
CNE	IC₅₀	0.34 μM Compound: CPT	Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay Antiproliferative activity against human CNE1 cells after 72 hrs by MTT assay	[PMID: 30125725]
CNE-2	IC₅₀	0.1 μM Compound: Camptothecin	Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human CNE2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30025344]
CNE-2	IC₅₀	0.98 μM Compound: CPT	Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay Antiproliferative activity against human CNE2 cells after 72 hrs by MTT assay	[PMID: 30125725]
Col2	IC₅₀	0.045 μM Compound: CPT	Cytotoxicity against human Col2 cells by MTT assay Cytotoxicity against human Col2 cells by MTT assay	[PMID: 21353568]
Col2	IC₅₀	0.045 μM Compound: camptothecin	Cytotoxicity against human Col2 cells by SRB assay Cytotoxicity against human Col2 cells by SRB assay	[PMID: 17498951]
COLO 205	IC₅₀	0.05 μM Compound: Camptothecin	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 24041234]
CRL-7065 cell line	CC₅₀	0.3 μM Compound: Camptothecin	Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay	[PMID: 22884523]
CRL-7065 cell line	CC₅₀	0.3 μM Compound: Camptothecin	Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay Cytotoxicity against human CRL7065 cells after 96 hrs by MTT assay	[PMID: 22047799]
CRL-7065 cell line	IC₅₀	0.5 μM Compound: CPT	Antiproliferative activity against human CRL7065 cells by MTT assay Antiproliferative activity against human CRL7065 cells by MTT assay	[PMID: 17254669]
CT26.WT	IC₅₀	0.43 μM Compound: CPT	Antiproliferative activity against mouse CT26.WT cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against mouse CT26.WT cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 35868003]
Detroit 551	GI₅₀	0.99 μM Compound: CPT	Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay Cytotoxicity against human Detroit 551 cells after 48 hrs by MTT assay	[PMID: 20662543]
Detroit 551	IC₅₀	0.99 μM Compound: CPT	Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human Detroit 551 cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
Detroit 551	GI₅₀	0.99 μM Compound: CPT	Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay Cytotoxicity against human Detroit 551 cells after 72 hrs by XTT assay	[PMID: 20591678]
DU-145	IC₅₀	0.01 μM Compound: CPT	Antiproliferative activity against human DU145 cells by MTT assay Antiproliferative activity against human DU145 cells by MTT assay	[PMID: 17254669]
DU-145	GI₅₀	0.01 μM Compound: 1	Growth inhibition of human DU145 cells after 48 hrs by SRB assay Growth inhibition of human DU145 cells after 48 hrs by SRB assay	[PMID: 24800942]
DU-145	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human DU145 cells after 48 hrs by SRB assay Cytotoxicity against human DU145 cells after 48 hrs by SRB assay	[PMID: 21823606]
DU-145	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 24502276]
DU-145	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human DU145 cells by SRB assay Antiproliferative activity against human DU145 cells by SRB assay	[PMID: 21710981]
DU-145	GI₅₀	0.01 μM Compound: 2	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
DU-145	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human DU145 cells after 48 hrs Antiproliferative activity against human DU145 cells after 48 hrs	[PMID: 27070999]
DU-145	CC₅₀	0.015 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 96 hrs by MTT assay Cytotoxicity against human DU145 cells after 96 hrs by MTT assay	[PMID: 22047799]
DU-145	IC₅₀	0.015 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 96 hrs Cytotoxicity against human DU145 cells after 96 hrs	[PMID: 22276775]
DU-145	IC₅₀	0.016 μM Compound: CPT	Cytotoxicity against human DU145 cells by MTT assay Cytotoxicity against human DU145 cells by MTT assay	[PMID: 30543429]
DU-145	GI₅₀	0.019 μM Compound: CPT	Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
DU-145	IC₅₀	0.02 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay Cytotoxicity against human DU145 cells after 48 hrs by CCK8 assay	[PMID: 26945111]
DU-145	IC₅₀	0.02 μM Compound: camptothecin	Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay Cytotoxicity against human DU145 cells measured on day 4 by CCK8 assay	[PMID: 25936262]
DU-145	IC₅₀	0.02 μM Compound: Camptothecin	Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human DU145 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
DU-145	GI₅₀	0.021 μM Compound: 1	Growth inhibition of human DU145 cells after 72 hrs by MTT assay Growth inhibition of human DU145 cells after 72 hrs by MTT assay	[PMID: 30336023]
DU-145	IC₅₀	0.0287 μM Compound: 1, CPT	Cytotoxicity against human DU145 cells by SRB assay Cytotoxicity against human DU145 cells by SRB assay	[PMID: 23102893]
DU-145	IC₅₀	0.029 μM Compound: 1, CPT	Cytotoxicity against human DU145 cells after 72 hrs by SRB assay Cytotoxicity against human DU145 cells after 72 hrs by SRB assay	[PMID: 25003995]
DU-145	IC₅₀	0.05 μM Compound: Camptothecin	Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay	[PMID: 31398033]
DU-145	IC₅₀	0.07 μM Compound: 45	Anti-proliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Anti-proliferative activity against human DU-145 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 33143937]
DU-145	CC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 96 hrs by MTT assay Cytotoxicity against human DU145 cells after 96 hrs by MTT assay	[PMID: 22884523]
DU-145	IC₅₀	0.1 μM Compound: CPT	Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as cell viability incubated for 72 hrs by MTT assay	[PMID: 25799376]
DU-145	IC₅₀	0.11 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days by CCK8 assay Cytotoxicity against human DU145 cells after 2 days by CCK8 assay	[PMID: 26361737]
DU-145	IC₅₀	0.11 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay	[PMID: 25481396]
DU-145	IC₅₀	0.11 μM Compound: Camptothecin	Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay Antiproliferative activity against human DU145 cells after 72 hrs by CCK8 assay	[PMID: 27643560]
DU-145	GI₅₀	0.21 μM Compound: CPT	Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 34008967]
DU-145	GI₅₀	0.21 μM Compound: CPT	Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay Growth inhibition of human DU145 cells incubated for 72 hrs by MTT assay	[PMID: 31176097]
DU-145	IC₅₀	0.21 μM Compound: CPT	Antiproliferative activity against human DU-145 cells after 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human DU-145 cells after 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34678573]
DU-145	IC₅₀	0.31 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days Cytotoxicity against human DU145 cells after 2 days	[PMID: 21419530]
DU-145	IC₅₀	0.38 μM Compound: Camptothecin	Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay Antiproliferative activity against human DU145 cells measured after 72 hrs by CCK8 assay	[PMID: 27654394]
DU-145	IC₅₀	0.39 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay Cytotoxicity against human DU145 cells after 2 days by CCK-8 assay	[PMID: 24013413]
DU-145	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay Cytotoxicity against human DU145 cells incubated from day 2 to day 4 by CCK8 assay	[PMID: 26022080]
DU-145	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days Cytotoxicity against human DU145 cells after 2 days	[PMID: 21601964]
DU-145	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system Cytotoxicity against human DU145 cells after 2 days by automatic ELISA reader system	[PMID: 20392646]
DU-145	IC₅₀	0.61 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells by MTT assay Cytotoxicity against human DU145 cells by MTT assay	[PMID: 21115246]
DU-145	IC₅₀	0.66 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay Cytotoxicity against human DU145 cells after 4 days by ELISA reader assay	[PMID: 19939682]
DU-145	IC₅₀	0.8 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
DU-145	IC₅₀	0.95 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay Cytotoxicity against human DU145 cells after 4 days by CCK-8 assay	[PMID: 25062006]
DU-145	IC₅₀	1 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells by MTT assay Cytotoxicity against human DU145 cells by MTT assay	[PMID: 19836231]
DU-145	IC₅₀	1.06 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis Cytotoxicity against human DU145 cells after 2 days by cell counting kit-8 analysis	[PMID: 22503656]
DU-145	IC₅₀	1.46 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 3 days Cytotoxicity against human DU145 cells after 3 days	[PMID: 19954977]
DU-145	IC₅₀	1.99 μM Compound: Camptothecin	Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay Antiproliferative activity against human DU-145 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay	[PMID: 32526552]
DU-145	ED₅₀	10.9 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human DU145 cells by sulforhodamine B assay Cytotoxicity against human DU145 cells by sulforhodamine B assay	[PMID: 17350834]
DU-145	GI₅₀	18.2 nM Compound: 1	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 24502276]
DU-145	IC₅₀	2.37 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 2 days Cytotoxicity against human DU145 cells after 2 days	[PMID: 22318164]
DU-145	IC₅₀	3.2 μM Compound: Camptothecin	Cytotoxicity against human DU145 cells after 4 days by MTT assay Cytotoxicity against human DU145 cells after 4 days by MTT assay	[PMID: 20619511]
DU-145	IC₅₀	3.57 μM Compound: camptothecin	Cytotoxicity against human DU145 cells after 48 hrs by MTT assay Cytotoxicity against human DU145 cells after 48 hrs by MTT assay	[PMID: 20093033]
DU-145	IC₅₀	4.01 μM Compound: CPT	Cytotoxicity against human DU145 cells after 2 days Cytotoxicity against human DU145 cells after 2 days	[PMID: 24904965]
DU-145	IC₅₀	9.29 μM Compound: CPT	Cytotoxicity against human DU145 cells after 72 hrs by MTT assay Cytotoxicity against human DU145 cells after 72 hrs by MTT assay	[PMID: 22819942]
ECa-109 cell line	IC₅₀	9.52 μM Compound: CPT	Cytotoxicity against human ECA109 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human ECA109 cells assessed as decrease in cell proliferation after 48 hrs by MTT assay	[PMID: 27667553]
Erythrocyte	EC₅₀	429.9 μg/mL Compound: Camptothecin	Hemolytic activity in Homo sapiens (human) Erythrocyte after 30 min Hemolytic activity in Homo sapiens (human) Erythrocyte after 30 min	10.1007/s00044-010-9381-7
Fibroblast	IC₅₀	459.3 nM Compound: camptothecin	Cytotoxicity against human Fibroblasts by SRB assay Cytotoxicity against human Fibroblasts by SRB assay	[PMID: 21410162]
GLC4 cell line	IC₅₀	10 nM Compound: Cpt	Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human GLC4 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
H22	IC₅₀	0.54 μM Compound: 1; CPT	Antiproliferative activity against mouse H22 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against mouse H22 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
H69AR	IC₅₀	> 300 nM Compound: 1a	Cytotoxicity against human H69AR cells overexpressing MDR1 after 72 hrs by alamar blue assay Cytotoxicity against human H69AR cells overexpressing MDR1 after 72 hrs by alamar blue assay	[PMID: 21341674]
HBL-100	GI₅₀	0.23 μM Compound: Camptothecin	Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay Antiproliferative activity against human HBL100 cells after 48 hrs by SRB assay	[PMID: 23831507]
HBL-100	GI₅₀	0.23 μM Compound: CPT	Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HBL100 cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
HCC70	IC₅₀	0.044 μM Compound: Camptothecin	Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay	[PMID: 31398033]
HCCLM9	IC₅₀	> 150 μM Compound: CPT	Antiproliferative activity against human HCCLM9 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCCLM9 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
HCT-116	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human HCT116 cells after 3 days by SRB assay Cytotoxicity against human HCT116 cells after 3 days by SRB assay	[PMID: 23142674]
HCT-116	IC₅₀	< 0.1 μM Compound: CPT	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 22409771]
HCT-116	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
HCT-116	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
HCT-116	IC₅₀	≤ 0.1 μM Compound: CPT	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
HCT-116	IC₅₀	0.00015 μM Compound: CPT	Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay	[PMID: 25247770]
HCT-116	IC₅₀	0.003 μM Compound: Camptothecin	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HCT-116	IC₅₀	0.009 μM Compound: CPT	Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HCT116 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
HCT-116	IC₅₀	0.009 μM Compound: camptothecin	Cytotoxicity against human HCT116 cells after 72 hrs by MTS method Cytotoxicity against human HCT116 cells after 72 hrs by MTS method	[PMID: 11858737]
HCT-116	GI₅₀	0.009 μM Compound: CPT	Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay Growth inhibition of human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 31176097]
HCT-116	GI₅₀	0.009 μM Compound: 1	Growth inhibition of human HCT116 cells after 72 hrs by MTT assay Growth inhibition of human HCT116 cells after 72 hrs by MTT assay	[PMID: 30336023]
HCT-116	GI₅₀	0.009 μM Compound: CPT	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
HCT-116	IC₅₀	0.0115 μM Compound: CPT	Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28454671]
HCT-116	IC₅₀	0.013 μM Compound: CPT	Cytotoxicity against human HCT116 cells by MTT assay Cytotoxicity against human HCT116 cells by MTT assay	[PMID: 30543429]
HCT-116	IC₅₀	0.016 μM Compound: camptothecin	Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay Cytotoxicity against human HCT116 cells after 72 hrs by WST-8 assay	[PMID: 24033077]
HCT-116	IC₅₀	0.017 μM Compound: CPT	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 34052678]
HCT-116	IC₅₀	0.02 μM Compound: CPT	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
HCT-116	IC₅₀	0.03 μM Compound: Camptothecin	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 31546197]
HCT-116	GI₅₀	0.03 μM Compound: 1	Growth inhibition of human HCT116 cells after 48 hrs by SRB assay Growth inhibition of human HCT116 cells after 48 hrs by SRB assay	[PMID: 24800942]
HCT-116	GI₅₀	0.03 μM Compound: 1	Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay	[PMID: 21823606]
HCT-116	GI₅₀	0.03 μM Compound: 1	Cytotoxicity against human HCT116 cells by SRB assay Cytotoxicity against human HCT116 cells by SRB assay	[PMID: 24502276]
HCT-116	GI₅₀	0.03 μM Compound: 1	Antiproliferative activity against human HCT116 cells by SRB assay Antiproliferative activity against human HCT116 cells by SRB assay	[PMID: 21710981]
HCT-116	GI₅₀	0.03 μM Compound: 2	Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HCT116 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
HCT-116	GI₅₀	0.03 μM Compound: 1	Antiproliferative activity against human HCT116 cells after 48 hrs Antiproliferative activity against human HCT116 cells after 48 hrs	[PMID: 27070999]
HCT-116	IC₅₀	0.04 μM Compound: CPT	In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human HCT-116 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
HCT-116	IC₅₀	0.05 μM Compound: CPT	Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
HCT-116	GI₅₀	0.05 μM Compound: CPT	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 34008967]
HCT-116	GI₅₀	0.05 μM Compound: Camptothecin	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
HCT-116	IC₅₀	0.07 μM Compound: 1, CPT	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 24069881]
HCT-116	GI₅₀	0.075 μM Compound: CPT	Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay Growth inhibition of human HCT116 cells expressing siTOP1 incubated for 72 hrs by MTT assay	[PMID: 31176097]
HCT-116	GI₅₀	0.075 μM Compound: 1	Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay Growth inhibition of human HCT116 cells expressing TOP1 siRNA after 72 hrs by MTT assay	[PMID: 30336023]
HCT-116	GI₅₀	0.075 μM Compound: CPT	Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells expressing TOP1 siRNA assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
HCT-116	GI₅₀	0.083 μM Compound: 1, CPT	Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
HCT-116	IC₅₀	0.09 μM Compound: 1; CPT	Antiproliferative activity against human HCT-116 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
HCT-116	IC₅₀	0.09 μM Compound: CPT	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 26226379]
HCT-116	IC₅₀	0.11 μM Compound: CPT	Antiproliferative activity against human HCT116 cells after 3 days by MTT assay Antiproliferative activity against human HCT116 cells after 3 days by MTT assay	[PMID: 23084702]
HCT-116	IC₅₀	0.12 μM Compound: CPT	Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 28351590]
HCT-116	IC₅₀	0.13 μM Compound: CPT	Antiproliferative activity against human HCT116 cells after 3 days by XTT assay Antiproliferative activity against human HCT116 cells after 3 days by XTT assay	[PMID: 19691293]
HCT-116	IC₅₀	0.159 μM Compound: Camptothecin	Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells measured after 48 hrs by MTT assay	[PMID: 28477443]
HCT-116	IC₅₀	0.159 μM Compound: Camptothecin	Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 27318980]
HCT-116	GI₅₀	0.195 μM Compound: Camptothecin	Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human HCT-116 p53-/- cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
HCT-116	IC₅₀	0.25 μM Compound: CPT	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 33158579]
HCT-116	IC₅₀	0.4 μM Compound: CPT	Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antitumor activity against human HCT-116 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 32668379]
HCT-116	IC₅₀	0.6 μM Compound: CPT	Cytotoxicity against human HCT-116 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
HCT-116	IC₅₀	1.88 μM Compound: CPT	Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
HCT-116	IC₅₀	1.88 μM Compound: CPT	Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28923388]
HCT-116	GI₅₀	17.38 nM Compound: 1	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	[PMID: 24502276]
HCT-116	IC₅₀	2 nM Compound: camptothecin	Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-116	IC₅₀	2.01 nM Compound: Camptothecin	Cytotoxicity against human HCT-116 cells assessed as cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell viability incubated for 24 hrs by MTT assay	[PMID: 35567964]
HCT-116	IC₅₀	2.3 μM Compound: Camptothecin	Cytotoxicity against human HCT116 cells after 4 days by MTT assay Cytotoxicity against human HCT116 cells after 4 days by MTT assay	[PMID: 20619511]
HCT-116	IC₅₀	2.77 μM Compound: Camptothecin	Cytotoxicity against human HCT116 cells after 3 days Cytotoxicity against human HCT116 cells after 3 days	[PMID: 19954977]
HCT-116	IC₅₀	22.9 nM Compound: 1, CPT	Cytotoxicity against human HCT116 after 72 hrs by SRB assay Cytotoxicity against human HCT116 after 72 hrs by SRB assay	[PMID: 22647222]
HCT-116	IC₅₀	3.97 μM Compound: Camptothecin	Cytotoxicity against human HCT116 cells after 2 days Cytotoxicity against human HCT116 cells after 2 days	[PMID: 21419530]
HCT-116	GI₅₀	35.48 nM Compound: 1	Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells transfected with Top1-siRNA after 72 hrs by MTT assay	[PMID: 24502276]
HCT-116	IC₅₀	6.7 μM Compound: CPT	Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells measured after 72 hrs by MTT assay	[PMID: 27721148]
HCT-116	IC₅₀	8.5 nM Compound: Camptothecin	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay	[PMID: 32952994]
HCT-15	IC₅₀	0.0014 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay Cytotoxicity against human HCT15 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay	[PMID: 27484510]
HCT-15	IC₅₀	0.02 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK-8 assay	[PMID: 29510948]
HCT-15	IC₅₀	0.049 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay	[PMID: 31398033]
HCT-15	IC₅₀	0.05 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells incubated for 72 hrs by CCK8 assay	[PMID: 29402741]
HCT-15	IC₅₀	0.05 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay Antiproliferative activity against human HCT15 cells after 72 hrs by EZ-CYTOX reagent based assay	[PMID: 30262132]
HCT-15	IC₅₀	0.067 μM Compound: Camptothecin	Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human HCT15 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
HCT-15	IC₅₀	0.08 μM Compound: CPT, campothecin	Cytotoxicity against human HCT15 cells by SRB assay Cytotoxicity against human HCT15 cells by SRB assay	[PMID: 17827007]
HCT-15	IC₅₀	0.08 μM Compound: CPT	Antiproliferative activity against human HCT-15 cells after 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human HCT-15 cells after 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34678573]
HCT-15	IC₅₀	0.083 μM Compound: camptothecin	Cytotoxicity against human HCT15 cells after 48 hrs Cytotoxicity against human HCT15 cells after 48 hrs	[PMID: 17673337]
HCT-15	IC₅₀	0.096 μg/mL Compound: CPT	Cytotoxicity against human HCT15 cells by sulforhodamine B assay Cytotoxicity against human HCT15 cells by sulforhodamine B assay	[PMID: 21684168]
HCT-15	IC₅₀	0.166 μM Compound: CPT	Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay Cytotoxicity against human HCT15 cells after 48 hrs by MTT assay	[PMID: 21873069]
HCT-15	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay	[PMID: 25481396]
HCT-15	IC₅₀	0.26 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 28384547]
HCT-15	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days Cytotoxicity against human HCT15 cells after 2 days	[PMID: 22318164]
HCT-15	IC₅₀	0.3 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay Cytotoxicity against human HCT15 cells after 2 days by CCK8 assay	[PMID: 26361737]
HCT-15	IC₅₀	0.31 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 27643560]
HCT-15	IC₅₀	0.35 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells measured after 72 hrs by CCK8 assay	[PMID: 27654394]
HCT-15	IC₅₀	0.42 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay Cytotoxicity against human HCT15 cells after 2 days by CCK-8 assay	[PMID: 24013413]
HCT-15	IC₅₀	0.5 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days Cytotoxicity against human HCT15 cells after 2 days	[PMID: 21601964]
HCT-15	IC₅₀	0.5 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system Cytotoxicity against human HCT15 cells after 2 days by automatic ELISA reader system	[PMID: 20392646]
HCT-15	IC₅₀	0.52 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay Cytotoxicity against human HCT15 cells incubated from day 2 to day 4 by CCK8 assay	[PMID: 26022080]
HCT-15	IC₅₀	0.6 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 28068603]
HCT-15	IC₅₀	0.76 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 28633898]
HCT-15	IC₅₀	0.76 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay Cytotoxicity against human HCT15 cells after 4 days by ELISA reader assay	[PMID: 19939682]
HCT-15	IC₅₀	0.8 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells by MTT assay Cytotoxicity against human HCT15 cells by MTT assay	[PMID: 21115246]
HCT-15	IC₅₀	1.29 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay Cytotoxicity against human HCT15 cells after 3 days by CCK8 assay	[PMID: 26927425]
HCT-15	IC₅₀	1.38 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis Cytotoxicity against human HCT15 cells after 2 days by cell counting kit-8 analysis	[PMID: 22503656]
HCT-15	IC₅₀	1.59 μM Compound: Camptothecin	Antiproliferative activity against human HCT-15 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay Antiproliferative activity against human HCT-15 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay	[PMID: 32526552]
HCT-15	IC₅₀	1.98 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay Cytotoxicity against human HCT15 cells after 4 days by CCK-8 assay	[PMID: 25062006]
HCT-15	IC₅₀	10.07 μM Compound: CPT	Cytotoxicity against human HCT15 cells after 2 days Cytotoxicity against human HCT15 cells after 2 days	[PMID: 24904965]
HCT-15	IC₅₀	2.82 μM Compound: Camptothecin	Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay Cytotoxicity against human HCT15 cells after 48 hrs by CCK8 assay	[PMID: 26945111]
HCT-15	IC₅₀	2.82 μM Compound: camptothecin	Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay Cytotoxicity against human HCT15 cells measured on day 4 by CCK8 assay	[PMID: 25936262]
HCT-15	IC₅₀	3 nM Compound: camptothecin	Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay	[PMID: 19655762]
HCT-15	IC₅₀	6.08 μM Compound: CPT	Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay Cytotoxicity against human HCT15 cells measured after 2 days by MTT assay	[PMID: 26334499]
HCT-15	IC₅₀	7.1 μM Compound: Camptothecin	Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay Antiproliferative activity against human HCT15 cells after 72 hrs by CCK8 assay	[PMID: 26988802]
HCT-15	IC₅₀	9.92 μM Compound: CPT	Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay	[PMID: 22819942]
HCT-8	IC₅₀	< 0.005 μg/mL Compound: 1 Camptothecin	In vitro cytotoxicity against HCT-8 cell line (human colon cancer) using MTT assay In vitro cytotoxicity against HCT-8 cell line (human colon cancer) using MTT assay	[PMID: 15225719]
HCT-8	IC₅₀	< 0.013 μM Compound: CPT	Cytotoxicity against human HCT8 cells after 3 days by MTT assay Cytotoxicity against human HCT8 cells after 3 days by MTT assay	[PMID: 20392545]
HCT-8	IC₅₀	0.024 μM Compound: 1; CPT	Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay Antiproliferative activity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 27871039]
HCT-8	IC₅₀	0.26 μM Compound: Camptothecin	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 22044245]
HCT-8	IC₅₀	3.15 μM Compound: camptothecin	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 18095653]
HCT-8	IC₅₀	3.2 μM Compound: camptothecin	Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay	[PMID: 19256478]
HCT-8	IC₅₀	3.6 μM Compound: camptothecin	Cytotoxicity against human HCT8 cells by MTT assay Cytotoxicity against human HCT8 cells by MTT assay	[PMID: 25237727]
HEC-1B cell line	IC₅₀	8.64 μM Compound: Camptothecin	In vitro antiproliferative activity of compound against HEC-1-B (human endometrical caner ) cell line was determined by SRB assay In vitro antiproliferative activity of compound against HEC-1-B (human endometrical caner ) cell line was determined by SRB assay	[PMID: 12639541]
HEK293	IC₅₀	0.01 μM Compound: Camptothecin	Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay Cytotoxicity against HEK293 cells measured after 48 hrs by MTT assay	[PMID: 28027871]
HEK293	IC₅₀	0.28 μM Compound: Camptothecin	Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay Cytotoxicity against HEK293 cells after 4 days by CCK-8 assay	[PMID: 25062006]
HEK293	IC₅₀	0.6 μM Compound: CPT	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 32668379]
HEK293	IC₅₀	0.78 μM Compound: Camptothecin	Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay Cytotoxicity against HEK293 cells after 2 days by CCK-8 assay	[PMID: 24013413]
HEK293	IC₅₀	0.83 μM Compound: Camptothecin	Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay Antiproliferative activity against HEK293 cells after 72 hrs by CCK8 assay	[PMID: 27643560]
HEK293	IC₅₀	0.89 μM Compound: CPT	Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells measured after 72 hrs by MTT assay	[PMID: 27721148]
HEK293	IC₅₀	1.01 μM Compound: Camptothecin	Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis Cytotoxicity against human HEK293 cells after 2 days by cell counting kit-8 analysis	[PMID: 22503656]
HEK293	IC₅₀	1.61 μM Compound: CPT	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
HEK293	IC₅₀	5.6 nM Compound: CPT	Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis	[PMID: 34952177]
HEK293	IC₅₀	5.6 x 10^-4 μM Compound: CPT	Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human HEK293 cells after 48 hrs by CCK-8 assay	[PMID: 29501943]
HEK293	IC₅₀	54.69 μM Compound: Camptothecin	Cytotoxicity in human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity in human HEK293 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 28923382]
HEK293	IC₅₀	7.94 μM Compound: CPT	Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay	[PMID: 22819942]
HEK293	IC₅₀	8.75 μM Compound: CPT	Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hr by MTT assay	[PMID: 32682183]
HEK-293T	IC₅₀	0.69 μM Compound: CPT	Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay Cytotoxicity against human HEK293T cells measured after 72 hrs by MTT assay	[PMID: 35612499]
HEK-293T	IC₅₀	5.65 μM Compound: CPT	Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
HeLa	IC₅₀	> 50 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30109008]
HeLa	GI₅₀	0.0054 μM Compound: CPT	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay	[PMID: 27597409]
HeLa	IC₅₀	0.0089 μM Compound: 1, CPT	Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay	[PMID: 21071230]
HeLa	GI₅₀	0.01 μM Compound: camptothecin	Growth inhibition of HeLa cells after 4 days Growth inhibition of HeLa cells after 4 days	[PMID: 17418582]
HeLa	GI₅₀	0.04 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay	[PMID: 19715319]
HeLa	GI₅₀	0.05 μM Compound: Camptothecin	Growth inhibition of human HeLa cells after 48 hrs by MTT assay Growth inhibition of human HeLa cells after 48 hrs by MTT assay	[PMID: 23357037]
HeLa	IC₅₀	0.06 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 28384547]
HeLa	IC₅₀	0.072 μM Compound: CPT	Cytotoxicity against human HeLa cells by sulforhodamine B assay Cytotoxicity against human HeLa cells by sulforhodamine B assay	[PMID: 19345580]
HeLa	GI₅₀	0.08 μM Compound: CPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 20662543]
HeLa	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay Cytotoxicity against human HeLa cells after 48 hrs by WST-1 assay	[PMID: 28557449]
HeLa	IC₅₀	0.09 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 28068603]
HeLa	IC₅₀	0.12 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability by MTT assay	[PMID: 28425292]
HeLa	IC₅₀	0.13 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK-8 assay	[PMID: 29510948]
HeLa	IC₅₀	0.13 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell growth after 72 hrs by CCK8 assay	[PMID: 27484510]
HeLa	IC₅₀	0.13 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells by SRB assay Antiproliferative activity against human HeLa cells by SRB assay	[PMID: 24200393]
HeLa	IC₅₀	0.18 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay Cytotoxicity against human HeLa cells after 48 hrs by CCK8 assay	[PMID: 26945111]
HeLa	IC₅₀	0.18 μM Compound: camptothecin	Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay Cytotoxicity against human HeLa cells measured on day 4 by CCK8 assay	[PMID: 25936262]
HeLa	GI₅₀	0.18 μM Compound: 1, camptothecin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 18180162]
HeLa	IC₅₀	0.18 μM Compound: CPT	Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
HeLa	IC₅₀	0.19 μg/mL Compound: camptothecin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 18774864]
HeLa	ED₅₀	0.19 μg/mL Compound: Camptothecin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 18220355]
HeLa	GI₅₀	0.19 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
HeLa	IC₅₀	0.2 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human HeLa cells after 48 hrs by SRB assay	[PMID: 19715319]
HeLa	IC₅₀	0.23 μM Compound: CPT	Antiproliferative activity against human HeLa cells after 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human HeLa cells after 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34678573]
HeLa	IC₅₀	0.28 μg/mL Compound: Camptothecin	Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay Cytotoxicity against Homo sapiens (human) HeLa cells by MTT assay	10.1007/s00044-010-9381-7
HeLa	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay Cytotoxicity against human HeLa cells after 2 days by CCK-8 assay	[PMID: 25481396]
HeLa	IC₅₀	0.4 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 27643560]
HeLa	IC₅₀	0.4 μM Compound: CPT	Cytotoxicity against human HeLa cells after 48 hrs by MTS assay Cytotoxicity against human HeLa cells after 48 hrs by MTS assay	[PMID: 23153813]
HeLa	IC₅₀	0.4 μM Compound: CPT	Cytotoxicity against human HeLa cells after 48 hrs by MTS assay Cytotoxicity against human HeLa cells after 48 hrs by MTS assay	[PMID: 22542106]
HeLa	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 2 days Cytotoxicity against human HeLa cells after 2 days	[PMID: 21601964]
HeLa	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system Cytotoxicity against human HeLa cells after 2 days by automatic ELISA reader system	[PMID: 20392646]
HeLa	IC₅₀	0.41 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay Cytotoxicity against human HeLa cells incubated from day 2 to day 4 by CCK8 assay	[PMID: 26022080]
HeLa	IC₅₀	0.42 μM Compound: CPT, Camptothecin	Cytotoxicity against human HeLa cells after 24 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 hrs by MTT assay	[PMID: 24980118]
HeLa	IC₅₀	0.5 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
HeLa	IC₅₀	0.5 μM Compound: camptothecine	Cytotoxicity against human HeLa cells by MTT method Cytotoxicity against human HeLa cells by MTT method	[PMID: 17547457]
HeLa	IC₅₀	0.5 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay	[PMID: 31398033]
HeLa	IC₅₀	0.58 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 19836231]
HeLa	IC₅₀	0.59 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 3 days by CCK8 assay Cytotoxicity against human HeLa cells after 3 days by CCK8 assay	[PMID: 26927425]
HeLa	GI₅₀	0.6 μM Compound: Camptothecin	Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay Growth inhibitory concentration of compound was determined against HeLa cells by alamar blue assay	[PMID: 15026047]
HeLa	GI₅₀	0.6 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay Antiproliferative activity against human HeLa cells after 48 hrs by SRB assay	[PMID: 23831507]
HeLa	IC₅₀	0.63 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay Cytotoxicity against human HeLa cells after 4 days by ELISA reader assay	[PMID: 19939682]
HeLa	IC₅₀	0.66 μM Compound: CPT	Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay Antiproliferative activity against human HeLa cells after 72 hrs by MTT assay	[PMID: 30125725]
HeLa	IC₅₀	0.86 μM Compound: camptothecin	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 20093033]
HeLa	IC₅₀	0.94 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 20356735]
HeLa	IC₅₀	0.94 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay Antiproliferative activity against human HeLa cells after 24 hrs by crystal violet staining-based assay	[PMID: 29407986]
HeLa	IC₅₀	1.01 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 2 days Cytotoxicity against human HeLa cells after 2 days	[PMID: 22318164]
HeLa	IC₅₀	1.08 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 2 days Cytotoxicity against human HeLa cells after 2 days	[PMID: 21419530]
HeLa	IC₅₀	1.1 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 4 days by MTT assay Cytotoxicity against human HeLa cells after 4 days by MTT assay	[PMID: 20619511]
HeLa	IC₅₀	1.22 μM Compound: camptothecin	Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry Cytotoxicity against human HeLa cells by SRB staining-based fluorescence cytometry	[PMID: 19653666]
HeLa	GI₅₀	1.3 μM Compound: 1	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21388138]
HeLa	IC₅₀	1.3 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells by MTT assay Antiproliferative activity against human HeLa cells by MTT assay	[PMID: 30007563]
HeLa	GI₅₀	1.3 μM Compound: CPT	Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HeLa cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
HeLa	IC₅₀	1.37 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells incubated for 72 hrs by CCK8 assay	[PMID: 29402741]
HeLa	IC₅₀	1.37 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay Antiproliferative activity against human HeLa cells after 72 hrs by EZ-CYTOX reagent based assay	[PMID: 30262132]
HeLa	IC₅₀	1.41 μM Compound: 1; CPT	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 27416553]
HeLa	IC₅₀	1.5 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21186067]
HeLa	IC₅₀	1.57 μM Compound: CPT	Cytotoxicity against human HeLa cells after 24 hrs by MTS assay Cytotoxicity against human HeLa cells after 24 hrs by MTS assay	[PMID: 23153813]
HeLa	IC₅₀	1.57 μM Compound: CPT	Cytotoxicity against human HeLa cells after 24 hrs by MTS assay Cytotoxicity against human HeLa cells after 24 hrs by MTS assay	[PMID: 22542106]
HeLa	IC₅₀	1.59 μM Compound: CPT	Cytotoxicity against human HeLa cells measured after 2 days by MTT assay Cytotoxicity against human HeLa cells measured after 2 days by MTT assay	[PMID: 26334499]
HeLa	IC₅₀	1.85 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells after 3 days Cytotoxicity against human HeLa cells after 3 days	[PMID: 19954977]
HeLa	IC₅₀	10.1 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 28462840]
HeLa	IC₅₀	11.36 μM Compound: CPT	Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as decrease in cell proliferation after 48 hrs by MTT assay	[PMID: 27667553]
HeLa	IC₅₀	11.62 μM Compound: CPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 25599951]
HeLa	IC₅₀	14 μM Compound: CPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26188908]
HeLa	IC₅₀	19.8 μM Compound: CPT	Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay Cytotoxicity against human HeLa cells assessed as cell growth inhibition after 24 hrs by XTT assay	[PMID: 26649907]
HeLa	IC₅₀	2.62 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay Antiproliferative activity against human HeLa cells after 72 hrs by CCK8 assay	[PMID: 28633898]
HeLa	IC₅₀	24 nM Compound: CPT	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 24900725]
HeLa	IC₅₀	3.8 μM Compound: CPT	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 28511910]
HeLa	IC₅₀	59.13 μM Compound: Camptothecin	Growth inhibition of human HeLa cells after 72 hrs by MTT assay Growth inhibition of human HeLa cells after 72 hrs by MTT assay	[PMID: 27344492]
HeLa	IC₅₀	6 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay	[PMID: 32526552]
HeLa	IC₅₀	6.13 μM Compound: Camptothecin	Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay Antiproliferative activity against human HeLa cells after 72 hrs by SRB assay	[PMID: 26602827]
HeLa	IC₅₀	6.51 μM Compound: CPT	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 30685528]
HeLa	IC₅₀	60.01 μM Compound: CPT	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28063351]
HeLa	IC₅₀	8.28 μM Compound: CPT	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34852457]
HeLa	IC₅₀	8.93 μM Compound: Camptothecin	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability after 24 hrs by MTT assay	[PMID: 21983445]
Hep 3B2	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human Hep3B cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
Hep 3B2	GI₅₀	0.01 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay	[PMID: 19715319]
Hep 3B2	IC₅₀	0.06 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human Hep3B cells after 48 hrs by SRB assay	[PMID: 19715319]
HEp-2	IC₅₀	0.02 μg/mL Compound: camptothecin	Cytotoxicity against human Hep2 cells by MTT assay Cytotoxicity against human Hep2 cells by MTT assay	[PMID: 18774864]
HEp-2	ED₅₀	0.02 μg/mL Compound: Camptothecin	Cytotoxicity against human Hep2 cells by MTT assay Cytotoxicity against human Hep2 cells by MTT assay	[PMID: 18220355]
HEp-2	IC₅₀	0.7 μM Compound: Camptothecin	Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human Hep2 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
HEp-2	IC₅₀	3.01 μM Compound: CPT	Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against against human Hep2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
HEp-2	IC₅₀	3.04 μM Compound: CPT	Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human Hep2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28923388]
HEp-2	IC₅₀	3.04 μM Compound: CPT	Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay Cytotoxicity against human Hep2 cells measured after 72 hrs by MTT assay	[PMID: 27721148]
HepG2	IC₅₀	< 0.1 μM Compound: CPT	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 22409771]
HepG2	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
HepG2	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
HepG2	IC₅₀	0.01 μM Compound: CPT	Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
HepG2	CC₅₀	0.02 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay	[PMID: 22047799]
HepG2	IC₅₀	0.02 μM Compound: CPT	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 36924947]
HepG2	IC₅₀	0.02 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 96 hrs Cytotoxicity against human HepG2 cells after 96 hrs	[PMID: 22276775]
HepG2	IC₅₀	0.03 μM Compound: CPT	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 17254669]
HepG2	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
HepG2	CC₅₀	0.04 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay Cytotoxicity against human HepG2 cells after 96 hrs by MTT assay	[PMID: 22884523]
HepG2	IC₅₀	0.05 μM Compound: CPT	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 24360564]
HepG2	IC₅₀	0.06 μM Compound: camptothecin	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 19863101]
HepG2	GI₅₀	0.1 μM Compound: 1, CPT	Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
HepG2	IC₅₀	0.11 μM Compound: 1; CPT	Antiproliferative activity against human HepG2 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
HepG2	IC₅₀	0.13 μM Compound: 1, CPT	Cytotoxicity against human HepG2 cells after 4 days by MTT assay Cytotoxicity against human HepG2 cells after 4 days by MTT assay	[PMID: 18554906]
HepG2	IC₅₀	0.2 μM Compound: Camptothecin	Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as cell viability after 48 hrs by MTT assay	10.1039/C4MD00344F
HepG2	IC₅₀	0.2 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 24041234]
HepG2	IC₅₀	0.2 μM Compound: 1, CPT	Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against human HepG2 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
HepG2	GI₅₀	0.22 μM Compound: 1, CPT	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
HepG2	IC₅₀	0.3 μM Compound: camptothecin	Cytotoxicity against human HEPG2 cells by MTT assay Cytotoxicity against human HEPG2 cells by MTT assay	[PMID: 18841903]
HepG2	IC₅₀	0.37 μM Compound: CPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30055465]
HepG2	IC₅₀	0.4 μM Compound: CPT	Antitumor activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antitumor activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 32668379]
HepG2	IC₅₀	0.43 μM Compound: Camp	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
HepG2	IC₅₀	0.5 μM Compound: Camptothecin	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 30007563]
HepG2	IC₅₀	0.6 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
HepG2	IC₅₀	0.66 μM Compound: CPT	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30600208]
HepG2	IC₅₀	1.36 μM Compound: CPT	Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 30125725]
HepG2	IC₅₀	1.52 μM Compound: 1; CPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 27416553]
HepG2	IC₅₀	13.2 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 30025344]
HepG2	IC₅₀	29.81 μM Compound: Camptothecin	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 27344492]
HepG2	IC₅₀	3.5 μM Compound: CPT	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34852457]
HepG2	IC₅₀	32.3 μM Compound: Camptothecin	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 23562244]
HepG2	IC₅₀	4.37 μM Compound: Camp	Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay Induction of apoptosis in human HepG2 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay	[PMID: 29223099]
HepG2	IC₅₀	4.79 μM Compound: CPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30685528]
HepG2	IC₅₀	4.92 μM Compound: CPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28511910]
HepG2	IC₅₀	455 nM Compound: camptothecin	Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay Cytotoxicity against human HepG2 cells after 72 hrs by MTS assay	[PMID: 19655762]
HepG2	IC₅₀	5.69 μM Compound: CPT	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 30875505]
HepG2	IC₅₀	6.08 μM Compound: CPT	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 30125725]
HepG2	IC₅₀	6.4 μM Compound: CPT	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	[PMID: 22326393]
HFL1	IC₅₀	1.06 μM Compound: Camptothecin	Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay Antiproliferative activity against HFL1 cells after 72 hrs by CCK8 assay	[PMID: 27643560]
HGC-27	IC₅₀	> 150 μM Compound: CPT	Antiproliferative activity against human HGC-27 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HGC-27 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
HGC-27	IC₅₀	0.166 μM Compound: CPT	Antiproliferative activity against human HGC-27 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 35868003]
HL-60	GI₅₀	< 0.003 μM Compound: 1, CPT	Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HL60 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
HL-60	IC₅₀	< 0.064 μM Compound: CPT; 1	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 30509782]
HL-60	IC₅₀	0.015 μM Compound: CPT	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 26188908]
HL-60	IC₅₀	0.017 μM Compound: 1, CPT	Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay	[PMID: 21071230]
HL-60	IC₅₀	0.018 μM Compound: Camptothecin	Antiproliferation activity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Antiproliferation activity against human HL60 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 32201190]
HL-60	IC₅₀	0.018 μM Compound: CPT	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 21353568]
HL-60	IC₅₀	0.018 μM Compound: camptothecin	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 17498951]
HL-60	IC₅₀	0.019 μM Compound: Camptothecin	Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay Antiproliferative activity against human HL60 cells measured after 48 hrs by WST1 assay	[PMID: 28477443]
HL-60	IC₅₀	0.019 μM Compound: Camptothecin	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 assay	[PMID: 27318980]
HL-60	IC₅₀	0.02 μM Compound: Camp	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
HL-60	GI₅₀	0.03 μM Compound: camptothecin	Growth inhibition of human HL60 cells by Almar blue assay Growth inhibition of human HL60 cells by Almar blue assay	[PMID: 17418582]
HL-60	IC₅₀	0.035 μM Compound: Camptothecin	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HL-60	IC₅₀	0.06 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 24041234]
HL-60	IC₅₀	0.065 μM Compound: camptothecin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 20093033]
HL-60	IC₅₀	0.065 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 2 days Cytotoxicity against human HL60 cells after 2 days	[PMID: 21419530]
HL-60	IC₅₀	0.067 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 19836231]
HL-60	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 25599951]
HL-60	IC₅₀	0.07 μM Compound: Camp	Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay Induction of apoptosis in human HL60 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay	[PMID: 29223099]
HL-60	IC₅₀	0.089 μM Compound: CPT	Cytotoxicity against human HL60 cells by sulforhodamine B assay Cytotoxicity against human HL60 cells by sulforhodamine B assay	[PMID: 19345580]
HL-60	IC₅₀	0.1 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 2 days Cytotoxicity against human HL60 cells after 2 days	[PMID: 21601964]
HL-60	IC₅₀	0.1 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system Cytotoxicity against human HL60 cells after 2 days by automatic ELISA reader system	[PMID: 20392646]
HL-60	IC₅₀	0.42 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 30109008]
HL-60	IC₅₀	0.59 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 20356735]
HL-60	IC₅₀	0.6 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells after 2 days by MTT assay Cytotoxicity against human HL60 cells after 2 days by MTT assay	[PMID: 22325897]
HL-60	IC₅₀	0.68 μM Compound: 1	Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells Inhibition of Topoisomerase I by cleavage complex formation in human HL-60 cells	[PMID: 8410981]
HL-60	IC₅₀	0.8 μM Compound: camptothecin	Cytotoxicity against human HL60 cells by rapid colorimetric assay Cytotoxicity against human HL60 cells by rapid colorimetric assay	[PMID: 19585998]
HL-60	IC₅₀	0.91 μM Compound: Camptothecin	Antitumor activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
HL-60	IC₅₀	0.92 μM Compound: Camptothecin	Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method Antiproliferative activity against human HL60 cells after 72 hrs by tryphan blue staining based hematocytometric method	[PMID: 29131616]
HL-60	GI₅₀	1.7 nM Compound: CPT, camptothecin	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 17962028]
HL-60	IC₅₀	1.7 μM Compound: Camptothecin	Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 33161122]
HL-60	IC₅₀	130 μM Compound: Camptothecin	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 15974606]
HL-60	IC₅₀	6 nM Compound: camptothecin	Cytotoxicity against human HL60 cells after 72 hrs by MTS assay Cytotoxicity against human HL60 cells after 72 hrs by MTS assay	[PMID: 19655762]
HL60/MX2	GI₅₀	1.5 nM Compound: CPT, camptothecin	Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay Cytotoxicity against DNA topoisomerase-2 deficient human HL60/MX2 cells by MTT assay	[PMID: 17962028]
HOC-21 cell line	IC₅₀	14.7 ng/mL Compound: 1a	Tested in vitro for the inhibition of HOC-21(human ovarian cancer) cell line by MTT assay Tested in vitro for the inhibition of HOC-21(human ovarian cancer) cell line by MTT assay	[PMID: 7932525]
HOP-62	GI₅₀	< 0.01 μM Compound: 18	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay	[PMID: 28418653]
HOP-62	GI₅₀	0.01 μM Compound: 1	Growth inhibition of human HOP62 cells after 48 hrs by SRB assay Growth inhibition of human HOP62 cells after 48 hrs by SRB assay	[PMID: 24800942]
HOP-62	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay	[PMID: 21823606]
HOP-62	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human HOP62 cells by SRB assay Cytotoxicity against human HOP62 cells by SRB assay	[PMID: 24502276]
HOP-62	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human HOP62 cells by SRB assay Antiproliferative activity against human HOP62 cells by SRB assay	[PMID: 21710981]
HOP-62	GI₅₀	0.01 μM Compound: 2	Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
HOP-62	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human HOP62 cells after 48 hrs Antiproliferative activity against human HOP62 cells after 48 hrs	[PMID: 27070999]
Hs 683	IC₅₀	< 0.01 μM Compound: Camptothecin	Growth inhibition of human Hs683 cells after 72 hrs by MTT assay Growth inhibition of human Hs683 cells after 72 hrs by MTT assay	[PMID: 24180210]
HT-1080	IC₅₀	0.08 μM Compound: CPT	Cytotoxicity against human HT1080 cells by MTT assay Cytotoxicity against human HT1080 cells by MTT assay	[PMID: 21353568]
HT-1080	IC₅₀	0.08 μM Compound: camptothecin	Cytotoxicity against human HT1080 cells by SRB assay Cytotoxicity against human HT1080 cells by SRB assay	[PMID: 17498951]
HT-29	IC₅₀	> 100 μM Compound: CPT	Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
HT-29	IC₅₀	> 150 μM Compound: CPT	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
HT-29	IC₅₀	0.014 μM Compound: camptothecin	Growth inhibition of human HT29 cells by neutral red assay Growth inhibition of human HT29 cells by neutral red assay	[PMID: 17204425]
HT-29	IC₅₀	0.03 μM Compound: Camptothecin	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 31546197]
HT-29	GI₅₀	0.03 μM Compound: 1, CPT	Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay	[PMID: 19715319]
HT-29	GI₅₀	0.05 μM Compound: Camptothecin	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 23831811]
HT-29	GI₅₀	0.05 μM Compound: Camptothecin	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	[PMID: 21115210]
HT-29	IC₅₀	0.06 μM Compound: CPT	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 24360564]
HT-29	ED₅₀	0.06 μM Compound: Camptothecin	Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 3 days by sulforhodamine B assay	[PMID: 20939540]
HT-29	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 36924947]
HT-29	IC₅₀	0.0878 μM Compound: Camptothecin	Inhibitory concentration that reduced the viability of HT 29 cell population by 50%. Inhibitory concentration that reduced the viability of HT 29 cell population by 50%.	[PMID: 9003520]
HT-29	IC₅₀	0.09 μM Compound: 1, CPT	Cytotoxicity against human HT29 cells after 4 days by MTT assay Cytotoxicity against human HT29 cells after 4 days by MTT assay	[PMID: 18554906]
HT-29	IC₅₀	0.12 μM Compound: 1, CPT	Antitumor activity against human HT-29 cells by SRB method Antitumor activity against human HT-29 cells by SRB method	[PMID: 19541483]
HT-29	IC₅₀	0.4 μM Compound: 1, CPT	Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay Cytotoxicity against human HT-29 cells expressing p53 mutant after 48 hrs by SRB assay	[PMID: 19715319]
HT-29	IC₅₀	0.7 nM Compound: Camptothecin	Antiproliferative activity against human HT-29 cells by SRB assay Antiproliferative activity against human HT-29 cells by SRB assay	[PMID: 24200393]
HT-29	IC₅₀	0.85 μM Compound: camptothecin	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 20093033]
HT-29	IC₅₀	1.07 μM Compound: Camptothecin	Cytotoxicity against human HT-29 cells by MTT assay Cytotoxicity against human HT-29 cells by MTT assay	[PMID: 19836231]
HT-29	IC₅₀	1.22 μM Compound: camptothecin	Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry Cytotoxicity against human HT-29 cells by SRB staining-based fluorescence cytometry	[PMID: 19653666]
HT-29	IC₅₀	1.37 μM Compound: CPT	Antiproliferative activity against human HT-29 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 35868003]
HT-29	IC₅₀	1.4 μM Compound: Camptothecin	In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line aws determined by SRB assay In vitro antiproliferative activity of compound against HT-29 (human colon caner ) cell line aws determined by SRB assay	[PMID: 12639541]
HT-29	IC₅₀	10 μM Compound: Camptothecin	Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 21843907]
HT-29	IC₅₀	2 μM Compound: camptothecin	Cytotoxicity against human HT29 cells by MTT assay Cytotoxicity against human HT29 cells by MTT assay	[PMID: 18841903]
HT-29	IC₅₀	260 nM Compound: 1a	Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay	[PMID: 21341674]
HT-29	IC₅₀	3.16 μM Compound: 1, CPT	Cytotoxicity against human HT29 cells after 1 hr Cytotoxicity against human HT29 cells after 1 hr	[PMID: 18419110]
HT-29	IC₅₀	3.16 μM Compound: 1, camptothecin, CPT	Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs Antiproliferative activity against human HT29 cells after 1 hr of drug exposure measured after 72 hrs	[PMID: 18424133]
HT-29	IC₅₀	46 nM Compound: 1	Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay Cytotoxicity was determined in vitro in HT-29 cells(colon) of human tumor cell lines by using MTT assay	[PMID: 7853331]
HT-29	IC₅₀	8.81 μM Compound: 1, CPT	Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr Cytotoxicity against human mitoxantrone-resistant HT29 cells after 1 hr	[PMID: 18419110]
HT-29	IC₅₀	8.81 μM Compound: 1, camptothecin, CPT	Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs Antiproliferative activity against BCRP overexpressing mitoxantrone-resistant human HT29 cells after 1 hr of drug exposure measured after 72 hrs	[PMID: 18424133]
HT-29	IC₅₀	80 nM Compound: CPT	Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay Cytotoxicity against HT-29 tumor cell line determined by WST-1 assay	[PMID: 10841808]
Huh-7	IC₅₀	< 0.1 μM Compound: CPT	Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay	[PMID: 22409771]
Huh-7	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human Huh-7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human Huh-7 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
Huh-7	IC₅₀	≤ 0.1 μM Compound: CPT	Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
Huh-7	IC₅₀	0.0023 μM Compound: CPT	Cytotoxicity against human HuH7 cells by MTT assay Cytotoxicity against human HuH7 cells by MTT assay	[PMID: 30543429]
Huh-7	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay Cytotoxicity against human HuH7 cells after 72 hrs by SRB assay	[PMID: 25247770]
Huh-7	GI₅₀	0.006 μM Compound: CPT	Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human HuH7 cells assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 29705710]
Huh-7	IC₅₀	0.06 μM Compound: CPT	Cytotoxicity against human HuH7 cells after 3 days by SRB assay Cytotoxicity against human HuH7 cells after 3 days by SRB assay	[PMID: 23142674]
Huh-7	GI₅₀	0.099 μM Compound: 1	Growth inhibition of human HuH7 cells after 72 hrs by MTT assay Growth inhibition of human HuH7 cells after 72 hrs by MTT assay	[PMID: 30336023]
Huh-7	IC₅₀	0.1 μM Compound: CPT	Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay Cytotoxicity against human HuH7 cells assessed as inhibition of cell proliferation by sulforhodamine B assay	10.1039/C4MD00306C
Huh-7	IC₅₀	0.15 μM Compound: CPT	Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay Cytotoxicity against human HuH7 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
Huh-7	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay Cytotoxicity against human HuH7 cells after 48 hrs by CCK8 assay	[PMID: 30702286]
HUVEC	IC₅₀	0.01 μM Compound: CPT	Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HUVEC cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
HUVEC	IC₅₀	0.012 μM Compound: CPT	In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay In-vitro cytotoxic activity against human HUVEC cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
HUVEC	IC₅₀	0.2 μM Compound: Camptothecin	Toxicity against HUVEC incubated for 48 hrs by MTT assay Toxicity against HUVEC incubated for 48 hrs by MTT assay	[PMID: 25590864]
IGROV-1	IC₅₀	0.012 μM Compound: 1, CPT	Cytotoxicity against human IGROV1 cells after 72 hrs Cytotoxicity against human IGROV1 cells after 72 hrs	[PMID: 18419110]
IGROV-1	IC₅₀	1.65 μM Compound: 1, CPT	Cytotoxicity against human IGROV1 cells after 1 hr Cytotoxicity against human IGROV1 cells after 1 hr	[PMID: 18419110]
IMR-32	IC₅₀	0.08 μM Compound: Camptothecin	Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human IMR32 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
IMR-90	IC₅₀	0.43 μM Compound: Camptothecin	Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay Cytotoxicity against human IMR90 cells incubated for 3 days by SRB assay	[PMID: 22863526]
Jurkat	IC₅₀	0.026 μM Compound: Camptothecin	Cytotoxicity against human Jurkat cells after 2 days by MTT assay Cytotoxicity against human Jurkat cells after 2 days by MTT assay	[PMID: 22325897]
Jurkat	GI₅₀	0.06 μM Compound: Camptothecin	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
Jurkat	IC₅₀	0.085 μM Compound: CPT	Anticancer activity against human Jurkat cells after 48 hrs by MTT assay Anticancer activity against human Jurkat cells after 48 hrs by MTT assay	[PMID: 26890120]
Jurkat	GI₅₀	0.09 μM Compound: 1	Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay	[PMID: 21388138]
Jurkat	IC₅₀	0.1 μM Compound: 1; CPT	Anticancer activity against human Jurkat cells incubated for 48 hrs by MTT assay Anticancer activity against human Jurkat cells incubated for 48 hrs by MTT assay	[PMID: 34175539]
Jurkat	IC₅₀	0.11 μM Compound: CPT, Camptothecin	Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells after 24 hrs by MTT assay	[PMID: 24980118]
Jurkat	IC₅₀	1.4 nM Compound: camptothecin	Growth inhibition of human Jurkat cells after 96 hrs Growth inhibition of human Jurkat cells after 96 hrs	[PMID: 18061452]
Jurkat	IC₅₀	22 μM Compound: CPT	Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 48 hrs by MTT assay	[PMID: 30853330]
Jurkat	IC₅₀	51.5 μM Compound: CPT	Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay Antiproliferative activity against human Jurkat cells assessed as reduction in cell proliferation measured after 24 hrs by MTT assay	[PMID: 30853330]
K562	IC₅₀	< 0.003 μM Compound: CPT	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
K562	IC₅₀	< 0.003 μM Compound: CPT	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 26226379]
K562	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 24360564]
K562	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 36924947]
K562	IC₅₀	0.04 μM Compound: camptothecin	Cytotoxicity against human K562 cells after 5 days by XTT assay Cytotoxicity against human K562 cells after 5 days by XTT assay	[PMID: 18076140]
K562	IC₅₀	0.04 μM Compound: camptothecin	Growth inhibition of K562 cells by XTT assay after 5 days Growth inhibition of K562 cells by XTT assay after 5 days	[PMID: 17411092]
K562	GI₅₀	0.06 μM Compound: Camptothecin	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 21115210]
K562	GI₅₀	0.06 μM Compound: CPT	Cytotoxicity against human K562 cells after 72 hrs by XTT assay Cytotoxicity against human K562 cells after 72 hrs by XTT assay	[PMID: 20591678]
K562	IC₅₀	0.07 μM Compound: CPT	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 30055465]
K562	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human K562 cells after 4 days by ELISA reader assay Cytotoxicity against human K562 cells after 4 days by ELISA reader assay	[PMID: 19939682]
K562	IC₅₀	0.09 μM Compound: Camp	Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
K562	IC₅₀	0.13 μM Compound: Camptothecin	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 25590864]
K562	IC₅₀	0.32 μM Compound: CPT	Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
K562	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay Cytotoxicity against human K562 cells after 24 to 72 hrs by MTT assay	[PMID: 24303808]
K562	IC₅₀	0.58 μM Compound: Camptothecin	Antitumor activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
K562	IC₅₀	0.59 μM Compound: Camptothecin	Cytotoxicity against human K562 cells by MTT assay Cytotoxicity against human K562 cells by MTT assay	[PMID: 21115246]
K562	IC₅₀	0.711 μM Compound: Camp	Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay Induction of apoptosis in human K562 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay	[PMID: 29223099]
K562	IC₅₀	1.18 μM Compound: Camptothecin	Cytotoxicity against human K562 cells after 2 days Cytotoxicity against human K562 cells after 2 days	[PMID: 22318164]
K562	IC₅₀	1.4 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human K562 cells after 48 hrs by SRB assay	[PMID: 19715319]
K562	IC₅₀	2 nM Compound: camptothecin	Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay Cytotoxicity against imatinib-resistant human K562 cells after 72 hrs by MTT assay	[PMID: 20590148]
K562	IC₅₀	2 nM Compound: camptothecin	Cytotoxicity against human imitinib-resistant K562 cells by MTT assay Cytotoxicity against human imitinib-resistant K562 cells by MTT assay	[PMID: 20329739]
K562	IC₅₀	2.69 μM Compound: Camptothecin	Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay	[PMID: 32526552]
K562	IC₅₀	31 nM Compound: CPT	Cytotoxicity against human K562 cells after 72 hrs by MTT assay Cytotoxicity against human K562 cells after 72 hrs by MTT assay	[PMID: 24900725]
K562	IC₅₀	5.37 μM Compound: CPT	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 25599951]
KB	IC₅₀	< 0.005 μg/mL Compound: 1 Camptothecin	In vitro cytotoxicity against KB cell line (human epidermoid carcinoma of the nasopharynx) using MTT assay In vitro cytotoxicity against KB cell line (human epidermoid carcinoma of the nasopharynx) using MTT assay	[PMID: 15225719]
KB	IC₅₀	< 0.013 μM Compound: CPT	Cytotoxicity against human KB cells after 3 days by MTT assay Cytotoxicity against human KB cells after 3 days by MTT assay	[PMID: 20392545]
KB	IC₅₀	0.003 μM Compound: 1, CPT	Cytotoxicity against human KB cells after 4 days by MTT assay Cytotoxicity against human KB cells after 4 days by MTT assay	[PMID: 18554906]
KB	CC₅₀	0.006 μM Compound: Camptothecin	Compound concentration required to reduce the exponential growth of KB cells by 50% Compound concentration required to reduce the exponential growth of KB cells by 50%	[PMID: 9767632]
KB	IC₅₀	0.008 μM Compound: Camptothecin	Inhibitory concentration that reduced the viability of KB cell population by 50%. Inhibitory concentration that reduced the viability of KB cell population by 50%.	[PMID: 9003520]
KB	EC₅₀	0.01 μg/mL Compound: camptothecin	Cytotoxicity against human KB cells after 72 hrs by MTS method Cytotoxicity against human KB cells after 72 hrs by MTS method	[PMID: 11858737]
KB	IC₅₀	0.02 μM Compound: Camptothecin	Antiproliferative activity against human KB cells by SRB assay Antiproliferative activity against human KB cells by SRB assay	[PMID: 24200393]
KB	IC₅₀	0.037 μM Compound: 1, CPT	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 25003995]
KB	IC₅₀	0.037 μM Compound: 1	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B colorimetric assay	[PMID: 26994847]
KB	IC₅₀	0.121 μM Compound: 1, CPT	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 23102893]
KB	IC₅₀	1.22 μM Compound: camptothecin	Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry Cytotoxicity against human KB cells by SRB staining-based fluorescence cytometry	[PMID: 19653666]
KB	ED₅₀	20.9 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human KB cells by sulforhodamine B assay Cytotoxicity against human KB cells by sulforhodamine B assay	[PMID: 17350834]
KB	IC₅₀	28.7 nM Compound: Camptothecin	Cytotoxicity against human KB cells by MTT assay Cytotoxicity against human KB cells by MTT assay	[PMID: 11858760]
KB	IC₅₀	38 nM Compound: camptothecin	Cytotoxicity against human KB cells after 72 hrs by MTS assay Cytotoxicity against human KB cells after 72 hrs by MTS assay	[PMID: 19655762]
KB	IC₅₀	50 nM Compound: 1	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 28927790]
KB	IC₅₀	50 nM Compound: 1; CPT	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 28285912]
KB	IC₅₀	8.8 nM Compound: CPT	Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay Antiproliferative activity against human KB cells after 72 hrs by ethylene blue dye assay	[PMID: 22698783]
KB 3-1	IC₅₀	0.015 μM Compound: CPT	Cytotoxicity against human KB3-1 cells after 4 days by MTT assay Cytotoxicity against human KB3-1 cells after 4 days by MTT assay	[PMID: 18676151]
KB 3-1	IC₅₀	0.015 μM Compound: CPT	Cytotoxicity against human KB3-1 cells by MTT method Cytotoxicity against human KB3-1 cells by MTT method	[PMID: 18771930]
KB-V1	IC₅₀	0.025 μM Compound: CPT	Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay Cytotoxicity against human multidrug resistant MDR1 overexpressing human KBV1 cells after 4 days by MTT assay	[PMID: 18676151]
KB-V1	IC₅₀	0.025 μM Compound: CPT	Cytotoxicity against human KBV1 cells by MTT method Cytotoxicity against human KBV1 cells by MTT method	[PMID: 18771930]
KG-1	IC₅₀	1.6 μM Compound: Camptothecin	Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human KG-1 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 33161122]
KG-1	IC₅₀	2.31 μM Compound: Camptothecin	Antitumor activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human KG-1 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
L02	IC₅₀	> 150 μM Compound: CPT	Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
L02	IC₅₀	0.14 μM Compound: CPT	Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay Cytotoxicity against human L02 cells measured after 72 hrs by MTT assay	[PMID: 35612499]
L02	IC₅₀	2.15 μM Compound: CPT	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 30875505]
L1210	IC₅₀	0.014 μM Compound: 1	Concentration that inhibits the proliferation of L1210 cells by 50% Concentration that inhibits the proliferation of L1210 cells by 50%	[PMID: 2537428]
L1210	IC₅₀	510 nM Compound: CPT	Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against mouse L1210 cells overexpressing folate receptor assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24901491]
LN-229	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay Cytotoxicity against human LN229 cells after 48 hrs by CCK8 assay	[PMID: 30702286]
LNCaP	ED₅₀	> 10 μM Compound: Camptothecin	Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodamine B assay	[PMID: 19026551]
LNCaP	ED₅₀	2 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human LNCAP cells by sulforhodamine B assay Cytotoxicity against human LNCAP cells by sulforhodamine B assay	[PMID: 17350834]
LNCaP	IC₅₀	86.1 nM Compound: Camptothecin	Cytotoxicity against human LNCAP cells by MTT assay Cytotoxicity against human LNCAP cells by MTT assay	[PMID: 11858760]
LoVo	GI₅₀	0.008 μM Compound: 1	Cytotoxicity against human LoVo cells after 72 hrs by MTT assay Cytotoxicity against human LoVo cells after 72 hrs by MTT assay	[PMID: 21388138]
LoVo	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay Cytotoxicity against human LoVo cells after 48 hrs by CCK8 assay	[PMID: 30702286]
LoVo	IC₅₀	1.54 μM Compound: 1; CPT	Antiproliferative activity against human LoVo cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
LoVo	IC₅₀	3.1 μM Compound: CPT	Cytotoxicity against human LoVo cells after 3 days by MTT assay Cytotoxicity against human LoVo cells after 3 days by MTT assay	[PMID: 20942490]
LOX IMVI	IC₅₀	48 nM Compound: 1	Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay Cytotoxicity was determined in vitro in LOX cells (melanoma) of human tumor cell lines by using MTT assay	[PMID: 7853331]
Lu1	ED₅₀	> 10 μM Compound: Camptothecin	Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay	[PMID: 19026551]
Lu1	IC₅₀	28.7 nM Compound: Camptothecin	Cytotoxicity against human Lu1 cells by MTT assay Cytotoxicity against human Lu1 cells by MTT assay	[PMID: 11858760]
LX-1	IC₅₀	0.12 μM Compound: camptothecin	Cytotoxicity against human LX1 cells after 72 hrs by MTS method Cytotoxicity against human LX1 cells after 72 hrs by MTS method	[PMID: 11858737]
M059J	IC₅₀	5.5 μM Compound: CPT	Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay Cytotoxicity against human M059J cells assessed as cell growth inhibition after 24 hrs by XTT assay	[PMID: 26649907]
Mahlavu	IC₅₀	< 0.1 μM Compound: CPT	Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay Cytotoxicity against human Mahlavu cells after 72 hrs by SRB assay	[PMID: 22409771]
Mahlavu	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human Mahlavu cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
MCF10	IC₅₀	24.77 μM Compound: Camptothecin	Cytotoxicity against human MCF10 cells assessed as reduction in cell viability after 3 hrs by MTT assay Cytotoxicity against human MCF10 cells assessed as reduction in cell viability after 3 hrs by MTT assay	[PMID: 33962153]
MCF-10A	IC₅₀	0.27 μM Compound: CPT	Cytotoxicity against human MCF10A cells after 2 days Cytotoxicity against human MCF10A cells after 2 days	[PMID: 24904965]
MCF-10A	IC₅₀	0.97 μM Compound: Camptothecin	Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay Cytotoxicity against human MCF10A cells after 2 days by CCK8 assay	[PMID: 26361737]
MCF-10A	IC₅₀	2.19 μM Compound: 1; CPT	Antiproliferative activity against human MCF-10A cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF-10A cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
MCF-10A	IC₅₀	2.58 μM Compound: CPT	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36351049]
MCF-12A	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human MCF12A cells after 3 days by SRB assay Cytotoxicity against human MCF12A cells after 3 days by SRB assay	[PMID: 23142674]
MCF7	IC₅₀	< 0.0018 μM Compound: Camptothecin	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	< 0.0018 μM Compound: Camptothecin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	< 0.0018 μM Compound: Camptothecin	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	< 0.01 μM Compound: Camptothecin	Growth inhibition of human MCF7 cells after 72 hrs by MTT assay Growth inhibition of human MCF7 cells after 72 hrs by MTT assay	[PMID: 24180210]
MCF7	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 3 days by SRB assay Cytotoxicity against human MCF7 cells after 3 days by SRB assay	[PMID: 23142674]
MCF7	IC₅₀	< 0.024 μg/mL Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay	[PMID: 24940955]
MCF7	IC₅₀	< 0.1 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 22409771]
MCF7	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
MCF7	ED₅₀	> 10 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 2 days by sulforhodamine B assay	[PMID: 19026551]
MCF7	IC₅₀	≤ 0.1 μM Compound: CPT	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
MCF7	IC₅₀	0.0005 μM Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	IC₅₀	0.0006 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 25247770]
MCF7	GI₅₀	0.002 μM Compound: Camptothecin	Growth inhibition of human MCF7 cells after 48 hrs by MTT assay Growth inhibition of human MCF7 cells after 48 hrs by MTT assay	[PMID: 23357037]
MCF7	IC₅₀	0.003 μM Compound: 3	Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells in presence of 10 mM DTT after 48 hrs by SRB assay	[PMID: 25084144]
MCF7	GI₅₀	0.01 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 23831811]
MCF7	GI₅₀	0.01 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21115210]
MCF7	GI₅₀	0.01 μM Compound: 1	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 24800942]
MCF7	GI₅₀	0.01 μM Compound: 1, CPT	Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
MCF7	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 21710981]
MCF7	GI₅₀	0.01 μM Compound: camptothecin	Growth inhibition of adriamycin-resistant MCF7 cells after 4 days Growth inhibition of adriamycin-resistant MCF7 cells after 4 days	[PMID: 17418582]
MCF7	GI₅₀	0.01 μM Compound: camptothecin	Growth inhibition of MCF7 cells after 4 days Growth inhibition of MCF7 cells after 4 days	[PMID: 17418582]
MCF7	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human MCF7 cells after 48 hrs Antiproliferative activity against human MCF7 cells after 48 hrs	[PMID: 27070999]
MCF7	GI₅₀	0.012 μM Compound: CPT	Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay Growth inhibition of human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 31176097]
MCF7	GI₅₀	0.013 μM Compound: 18	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 28418653]
MCF7	GI₅₀	0.013 μM Compound: 1	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 21823606]
MCF7	GI₅₀	0.013 μM Compound: 1	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 24502276]
MCF7	GI₅₀	0.013 μM Compound: 2	Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
MCF7	IC₅₀	0.02 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 20392545]
MCF7	CC₅₀	0.02 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 22047799]
MCF7	IC₅₀	0.021 μM Compound: CPT	In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay In-vitro antitumor activity against human MCF7 cells incubated for 72 hrs by CCK8 assay	[PMID: 35550978]
MCF7	IC₅₀	0.03 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by SRB assay	[PMID: 31546197]
MCF7	IC₅₀	0.03 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 28274626]
MCF7	IC₅₀	0.04 μM Compound: CPT	Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
MCF7	IC₅₀	0.04 μM Compound: CPT	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 17254669]
MCF7	IC₅₀	0.056 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay Antiproliferative activity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 21978950]
MCF7	IC₅₀	0.06 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay Cytotoxicity against human MCF7 cells after 4 days by ELISA reader assay	[PMID: 19939682]
MCF7	GI₅₀	0.06 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
MCF7	IC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 21513293]
MCF7	EC₅₀	0.072 μM Compound: camptothecin	Cytotoxicity against human MCF7 after 3 days by SRB assay Cytotoxicity against human MCF7 after 3 days by SRB assay	[PMID: 15730238]
MCF7	IC₅₀	0.073 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 3 days by sulforhodamine B assay	[PMID: 28409637]
MCF7	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay Cytotoxicity against human MCF7 cells after 2 days by CCK-8 assay	[PMID: 25481396]
MCF7	CC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay Cytotoxicity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 22884523]
MCF7	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay Cytotoxicity against human MCF7 cells incubated for 3 days by SRB assay	[PMID: 22863526]
MCF7	IC₅₀	0.084 μM Compound: CPT	Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells incubated for 72 hrs by CCK8 assay	[PMID: 32292547]
MCF7	IC₅₀	0.2 μM Compound: 1, CPT	Cytotoxicity against human MCF7 cells after 4 days by MTT assay Cytotoxicity against human MCF7 cells after 4 days by MTT assay	[PMID: 18554906]
MCF7	GI₅₀	0.28 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay Antiproliferative activity against human MCF7 cells expressing estrogen receptor after 48 hrs by SRB assay	[PMID: 20438092]
MCF7	IC₅₀	0.34 μM Compound: Camp	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
MCF7	IC₅₀	0.35 μM Compound: CPT	Cytotoxicity against human MCF7 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
MCF7	GI₅₀	0.35 μM Compound: CPT	Cytotoxicity against human MCF-7 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF-7 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 34008967]
MCF7	IC₅₀	0.42 μM Compound: CPT	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30125725]
MCF7	IC₅₀	0.56 μM Compound: 1; CPT	Antiproliferative activity against human MCF7 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
MCF7	GI₅₀	0.57 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay Cytotoxicity against human MCF7 cells after 72 hrs by XTT assay	[PMID: 20591678]
MCF7	IC₅₀	0.65 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21186067]
MCF7	IC₅₀	0.68 μM Compound: CPT; 1	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 30509782]
MCF7	IC₅₀	0.68 μM Compound: CPT	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 30600208]
MCF7	IC₅₀	1.1 μM Compound: 1, CPT	Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay Cytotoxicity against estrogen receptor-positive human MCF7 cells expressing wild type p53 after 48 hrs by SRB assay	[PMID: 19715319]
MCF7	IC₅₀	1.22 μM Compound: camptothecin	Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry Cytotoxicity against human MCF7 cells by SRB staining-based fluorescence cytometry	[PMID: 19653666]
MCF7	IC₅₀	1.6 nM Compound: Camptothecin	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 22376176]
MCF7	IC₅₀	1.6 nM Compound: camptothecin	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 21410162]
MCF7	IC₅₀	1.67 μM Compound: CPT	Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
MCF7	IC₅₀	1.8 μM Compound: camptothecin	Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay Cytotoxicity against human tamoxifen-resistant MCF7 cells by WST-1 assay	[PMID: 22197145]
MCF7	IC₅₀	10 nM Compound: camptothecin	Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	IC₅₀	10 μM Compound: camptothecin	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 18841903]
MCF7	IC₅₀	13.62 μM Compound: Camptothecin	Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity in human MCF7 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 28923382]
MCF7	IC₅₀	14.2 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 4 days by MTT assay Cytotoxicity against human MCF7 cells after 4 days by MTT assay	[PMID: 20619511]
MCF7	IC₅₀	160 nM Compound: Camptothecin	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29541373]
MCF7	IC₅₀	2.43 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 21115246]
MCF7	IC₅₀	2.5 μM Compound: CPT	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hr by MTT assay	[PMID: 32682183]
MCF7	IC₅₀	2.5 μM Compound: CPT	Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis Poison activity at TOP1 in human MCF7 cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis	[PMID: 30897325]
MCF7	IC₅₀	2.6 μM Compound: camptothecin	Cytotoxicity against human MCF7 cells by WST-1 assay Cytotoxicity against human MCF7 cells by WST-1 assay	[PMID: 22197145]
MCF7	IC₅₀	2.8 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by CytoX cell viability assay	[PMID: 32526552]
MCF7	IC₅₀	26 nM Compound: CPT	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 24900725]
MCF7	IC₅₀	28.66 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28462840]
MCF7	IC₅₀	3 nM Compound: camptothecin	Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay Cytotoxicity against human MCF7 cells expressing P-glycoprotein after 72 hrs by MTS assay	[PMID: 19655762]
MCF7	ED₅₀	3.2 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human MCF7 cells by sulforhodamine B assay Cytotoxicity against human MCF7 cells by sulforhodamine B assay	[PMID: 17350834]
MCF7	GI₅₀	3.21 μM Compound: CPT	Cytotoxicity against human MCF-7/TDP1 cells assessed as cell growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF-7/TDP1 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 34008967]
MCF7	IC₅₀	3.3 nM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells by SRB assay Antiproliferative activity against human MCF7 cells by SRB assay	[PMID: 24200393]
MCF7	IC₅₀	3.91 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 2 days Cytotoxicity against human MCF7 cells after 2 days	[PMID: 22318164]
MCF7	IC₅₀	4.54 μM Compound: Camptothecin	Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by CCK8 assay	[PMID: 27654394]
MCF7	GI₅₀	6 μM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21388138]
MCF7	IC₅₀	6 μM Compound: CPT	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition after 24 hrs by XTT assay	[PMID: 26649907]
MCF7	IC₅₀	65.1 nM Compound: CPT	Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24901491]
MCF7	IC₅₀	7.42 μM Compound: Camptothecin	Cytotoxicity against human MCF7 cells after 3 days Cytotoxicity against human MCF7 cells after 3 days	[PMID: 19954977]
MCF7	IC₅₀	71.3 μM Compound: CPT	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28063351]
MCF7	IC₅₀	87.5 nM Compound: 1	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 28927790]
MCF7	IC₅₀	87.5 nM Compound: 1; CPT	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay	[PMID: 28285912]
MDA-MB-157	IC₅₀	0.02 μM Compound: CPT	Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay Cytotoxicity against human MDA-MB-157 cells after 3 days by SRB assay	[PMID: 23142674]
MDA-MB-231	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay Cytotoxicity against human MDA-MB-231 cells after 3 days by SRB assay	[PMID: 23142674]
MDA-MB-231	IC₅₀	> 6.4 μM Compound: 1; CPT	Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Top1 assessed as cell viability by MTT assay Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Top1 assessed as cell viability by MTT assay	[PMID: 34844412]
MDA-MB-231	IC₅₀	0.17 μM Compound: CPT	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 34171512]
MDA-MB-231	IC₅₀	0.241 μM Compound: CPT	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay	[PMID: 34052678]
MDA-MB-231	IC₅₀	0.291 μM Compound: camptothecin	Growth inhibition of human MDA-MB-231 cells by neutral red assay Growth inhibition of human MDA-MB-231 cells by neutral red assay	[PMID: 17204425]
MDA-MB-231	IC₅₀	0.3 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system Cytotoxicity against human MDA-MB-231 cells after 2 days by automatic ELISA reader system	[PMID: 20392646]
MDA-MB-231	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay Cytotoxicity against human MDA231 cells after 48 hrs by CCK8 assay	[PMID: 30702286]
MDA-MB-231	IC₅₀	0.33 μM Compound: CPT	Cytotoxicity against human MDA-MB-231 after 48 hrs by SRB assay Cytotoxicity against human MDA-MB-231 after 48 hrs by SRB assay	[PMID: 21044847]
MDA-MB-231	IC₅₀	0.342 μM Compound: CPT, Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 24980118]
MDA-MB-231	GI₅₀	0.4 μM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
MDA-MB-231	IC₅₀	0.42 μM Compound: 1; CPT	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
MDA-MB-231	IC₅₀	0.49 μM Compound: CPT	Cytotoxicity against human MDA-MB-231 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells expressing high level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
MDA-MB-231	IC₅₀	0.68 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells by MTT assay Cytotoxicity against human MDA-MB-231 cells by MTT assay	[PMID: 19836231]
MDA-MB-231	IC₅₀	0.92 μM Compound: camptothecin	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 20093033]
MDA-MB-231	IC₅₀	0.97 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 2 days Cytotoxicity against human MDA-MB-231 cells after 2 days	[PMID: 21419530]
MDA-MB-231	IC₅₀	1.06 μM Compound: CPT	Cytotoxicity against HER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against HER-negative human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36351049]
MDA-MB-231	IC₅₀	1.1 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 3 days Cytotoxicity against human MDA-MB-231 cells after 3 days	[PMID: 19954977]
MDA-MB-231	GI₅₀	1.3 μM Compound: Camptothecin	Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay Antiproliferative activity against estrogen receptor deficient human MDA-MB-231 cells after 48 hrs by SRB assay	[PMID: 20438092]
MDA-MB-231	IC₅₀	16.44 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 30109008]
MDA-MB-231	IC₅₀	162 nM Compound: CPT	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT assay	[PMID: 24900725]
MDA-MB-231	IC₅₀	2.11 μM Compound: CPT	Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
MDA-MB-231	IC₅₀	2.7 μM Compound: camptothecin	Cytotoxicity against human MDA-MB-231 cells by WST-1 assay Cytotoxicity against human MDA-MB-231 cells by WST-1 assay	[PMID: 22197145]
MDA-MB-231	IC₅₀	23.98 μM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay	[PMID: 31398033]
MDA-MB-231	IC₅₀	264 nM Compound: 1; CPT	Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Ctrl assessed as cell viability by MTT assay Antiproliferative activity against human MDA-MB-231 cells transfected with siRNA-Ctrl assessed as cell viability by MTT assay	[PMID: 34844412]
MDA-MB-231	IC₅₀	28.4 nM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 4 days by [3H]-thymidine incorporation assay	[PMID: 32952994]
MDA-MB-231	IC₅₀	307 nM Compound: 1	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 28927790]
MDA-MB-231	IC₅₀	307 nM Compound: 1; CPT	Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 72 hrs by sulforhodamine B assay	[PMID: 28285912]
MDA-MB-231	IC₅₀	4.2 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay Cytotoxicity against human MDA-MB-231 cells after 4 days by MTT assay	[PMID: 20619511]
MDA-MB-231	IC₅₀	5.77 μM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay	[PMID: 26602827]
MDA-MB-231	IC₅₀	540 nM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29541373]
MDA-MB-231	IC₅₀	8.83 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay	[PMID: 27707625]
MDA-MB-361	IC₅₀	0.17 μM Compound: CPT	Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay Cytotoxicity against human MDA-MB-361 cells after 3 days by SRB assay	[PMID: 23142674]
MDA-MB-435	IC₅₀	< 0.001 μM Compound: 1, CPT	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 24069881]
MDA-MB-435	GI₅₀	0.033 μM Compound: 1, CPT	Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
MDA-MB-435	IC₅₀	0.0436 μM Compound: CPT	Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay Antiproliferative activity against human MDA-MB-435 cells after 3 days by MTT assay	[PMID: 23084702]
MDA-MB-435	IC₅₀	0.31 μM Compound: 1; CPT	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition rate incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition rate incubated for 72 hrs by MTT assay	[PMID: 34844412]
MDA-MB-435	IC₅₀	0.71 μM Compound: CPT	Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay Cytotoxicity against human MDA-MB-435 cells after 3 days by MTT assay	[PMID: 20942490]
MDA-MB-435	IC₅₀	1 μM Compound: CPT	Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-435 cells after 72 hrs by MTT assay	[PMID: 26226379]
MDA-MB-435	IC₅₀	2.7 μM Compound: CPT	Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
MDA-MB-436	IC₅₀	31.86 μM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay	[PMID: 31398033]
MDA-MB-453	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay Cytotoxicity against human MDA-MB-453 cells after 3 days by SRB assay	[PMID: 23142674]
MDA-MB-468	IC₅₀	1.71 μM Compound: Camptothecin	Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay	[PMID: 27707625]
MDA-MB-468	IC₅₀	14.76 μM Compound: Camptothecin	Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-468 cells after 72 hrs by SRB assay	[PMID: 26602827]
MEF	IC₅₀	5.87 μg/mL Compound: Camptothecin	Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay Cytotoxicity against mouse MEF cells after 72 hrs by MTT assay	[PMID: 25867737]
MES-SA	IC₅₀	57 nM Compound: 1a	Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay	[PMID: 21341674]
MES-SA/Dx5	IC₅₀	52 nM Compound: 1a	Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay	[PMID: 21341674]
MFE-296	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay Cytotoxicity against human MFE296 cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
MGC-803	IC₅₀	> 150 μM Compound: CPT	Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MGC-803 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
MGC-803	IC₅₀	2.96 μM Compound: CPT	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 30685528]
MGC-803	IC₅₀	4.27 μM Compound: CPT	Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 30875505]
MGC-803	IC₅₀	9.45 μM Compound: Camptothecin	Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay	[PMID: 28462840]
MHCC97H	IC₅₀	0.32 nM Compound: Camptothecin	Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay Cytotoxicity against human MHCC97H cells after 48 hrs by CCK8 assay	[PMID: 30702286]
MIA PaCa-2	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as cell viability after 24 hrs by MTT assay	[PMID: 24484281]
MIA PaCa-2	IC₅₀	0.18 μM Compound: CPT	Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay Antiproliferative activity against human MIAPaCa2 cells after 48 hrs in presence of type 1 collagen coated surface by MTT assay	[PMID: 28689976]
MIA PaCa-2	IC₅₀	0.19 μM Compound: Camptothecin	Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against human MIAPaCa2 cells assessed as cell viability after 48 hrs by MTT assay	10.1039/C4MD00344F
MIA PaCa-2	IC₅₀	0.19 μM Compound: Camptothecin	Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 48 hrs by MTT assay	[PMID: 24041234]
MIA PaCa-2	IC₅₀	0.4 μM Compound: Camptothecin	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 21775156]
MOLT-4	IC₅₀	0.04 nM Compound: CPT	Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay Cytotoxicity against human MOLT4 cells after 72 hrs by MTT assay	[PMID: 24900725]
MRC5	CC₅₀	0.2 μM Compound: Camptothecin	Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay	[PMID: 22884523]
MRC5	CC₅₀	0.2 μM Compound: Camptothecin	Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay Cytotoxicity against human MRC5 cells after 96 hrs by MTT assay	[PMID: 22047799]
MRC5	IC₅₀	0.8 μM Compound: CPT	Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 3 days by resazurin staining based analysis Cytotoxicity against human MRC5 cells assessed as cell growth inhibition measured after 3 days by resazurin staining based analysis	[PMID: 34952177]
MRC5	IC₅₀	1.7 x 10^-5 μM Compound: CPT	Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human MRC5 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 33962152]
MRC5	IC₅₀	1.7 μM Compound: I; CPT	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by CCK8 assay	[PMID: 32279049]
MSTO-211H	GI₅₀	0.0021 μM Compound: CPT	Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay Growth inhibition of human MSTO-211H cells after 72 hrs by trypan blue assay	[PMID: 27597409]
MT4	CC₅₀	0.004 μM Compound: Camptothecin	Cytotoxicity against human MT4 cells after 96 hrs by MTT assay Cytotoxicity against human MT4 cells after 96 hrs by MTT assay	[PMID: 22884523]
MT4	IC₅₀	0.004 μM Compound: CPT	Antiproliferative activity against human MT4 cells by MTT assay Antiproliferative activity against human MT4 cells by MTT assay	[PMID: 17254669]
MT4	IC₅₀	0.004 μM Compound: Camptothecin	Cytotoxicity against human MT4 cells after 96 hrs Cytotoxicity against human MT4 cells after 96 hrs	[PMID: 22276775]
MT4	CC₅₀	0.01 μM Compound: Camptothecin	Compound concentration required to reduce the exponential growth of MT-4 cells by 50% Compound concentration required to reduce the exponential growth of MT-4 cells by 50%	[PMID: 9767632]
MX1	IC₅₀	1700 nM Compound: CPT	Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human MX1 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24901491]
NB-4	IC₅₀	2.01 μM Compound: Camptothecin	Antitumor activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human NB4 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
NCI/ADR-RES	IC₅₀	0.8 μM Compound: camptothecin	Cytotoxicity against human MCF7/ADR cells by WST-1 assay Cytotoxicity against human MCF7/ADR cells by WST-1 assay	[PMID: 22197145]
NCI-H1299	IC₅₀	0.8 μM Compound: Camptothecin	Cytotoxicity against human NCI-H1299 cells by MTT assay Cytotoxicity against human NCI-H1299 cells by MTT assay	[PMID: 28506750]
NCI-H1299	IC₅₀	3.14 μM Compound: CPT	Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human H1299 cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
NCI-H1975	IC₅₀	1.2 μM Compound: Camptothecin	Cytotoxicity against human NCI-H1975 cells by MTT assay Cytotoxicity against human NCI-H1975 cells by MTT assay	[PMID: 28506750]
NCI-H23	IC₅₀	0.07 μM Compound: CPT	Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay Cytotoxicity against human NCI-H23 cells assessed as cell viability after 96 hrs by MTT assay	[PMID: 27156772]
NCI-H446	IC₅₀	> 200 μM Compound: CPT	Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
NCI-H446	IC₅₀	> 200 μM Compound: CPT	Cytotoxicity against human NCI-H446 cells after 72 hrs by MTT assay Cytotoxicity against human NCI-H446 cells after 72 hrs by MTT assay	[PMID: 26226379]
NCI-H460	IC₅₀	< 0.04 μM Compound: Camptothecin	Cytotoxicity against human H460 cells after 72 hrs by MTS assay Cytotoxicity against human H460 cells after 72 hrs by MTS assay	[PMID: 21513293]
NCI-H460	IC₅₀	> 1000 nM Compound: 1a	Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay in presence of 40 mg/ml HSA Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay in presence of 40 mg/ml HSA	[PMID: 21341674]
NCI-H460	IC₅₀	> 25 μM Compound: CPT	Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 20638158]
NCI-H460	IC₅₀	0.002 μM Compound: Camptothecin	Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay Cytotoxicity against human NCI-H460 cells incubated for 3 days by SRB assay	[PMID: 22863526]
NCI-H460	GI₅₀	0.002 μM Compound: CPT	Growth inhibition of human H460 cells after 72 hrs by trypan blue assay Growth inhibition of human H460 cells after 72 hrs by trypan blue assay	[PMID: 27597409]
NCI-H460	IC₅₀	0.003 μM Compound: Camptothecin	Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H460 cells incubated for 72 hrs by MTT assay	[PMID: 22758788]
NCI-H460	GI₅₀	0.0057 μM Compound: Camptothecin	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
NCI-H460	IC₅₀	0.0062 μM Compound: 1, CPT	Cytotoxicity against human H460 cells after 72 hrs Cytotoxicity against human H460 cells after 72 hrs	[PMID: 18419110]
NCI-H460	EC₅₀	0.0069 μM Compound: camptothecin	Cytotoxicity against human H460 after 3 days by SRB assay Cytotoxicity against human H460 after 3 days by SRB assay	[PMID: 15730238]
NCI-H460	GI₅₀	0.03 μM Compound: CPT	Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay Cytotoxicity against human NCI-H460 cells after 72 hrs by XTT assay	[PMID: 20591678]
NCI-H460	IC₅₀	0.12 μM Compound: CPT	Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell viability measured after 48 hrs by MTT assay	[PMID: 32711231]
NCI-H460	IC₅₀	0.18 μM Compound: 1, camptothecin, CPT	Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs Antiproliferative activity against human H460 cells after 1 hr of drug exposure measured after 72 hrs	[PMID: 18424133]
NCI-H460	IC₅₀	0.19 μM Compound: CPT	Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell viability after 96 hrs by MTT assay	[PMID: 27156772]
NCI-H460	IC₅₀	0.33 μM Compound: 1, CPT	Cytotoxicity against human H460 cells after 1 hr Cytotoxicity against human H460 cells after 1 hr	[PMID: 18419110]
NCI-H460	IC₅₀	0.33 μM Compound: 1, CPT	Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium Antiproliferative activity against human NCI-H460 cells after short term exposure for 1 hr measured after 72 hrs in drug-free medium	[PMID: 19530720]
NCI-H460	IC₅₀	110 nM Compound: Camptothecin	Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human H460 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 29541373]
NCI-H460	IC₅₀	13 nM Compound: 1a	Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay	[PMID: 21341674]
NCI-H460	IC₅₀	5 nM Compound: Cpt	Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 72 hrs by sulforhodamine B assay	[PMID: 22749423]
NCI-H460	IC₅₀	5.37 μM Compound: CPT	Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 30875505]
NCI-H69	IC₅₀	1 nM Compound: 1a	Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay	[PMID: 21341674]
NCI-N87	IC₅₀	0.6 μM Compound: Camptothecin	Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay Cytotoxicity against human NCI-N87 cells assessed as reduction in cell growth after 72 hrs by CCK8 assay	[PMID: 27484510]
NCI-N87	IC₅₀	2.32 μM Compound: CPT	Cytotoxicity against HER-positive human NCI-N87 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against HER-positive human NCI-N87 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36351049]
OVCAR-3	GI₅₀	0.22 μM Compound: 18	Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay	[PMID: 28418653]
OVCAR-3	GI₅₀	0.22 μM Compound: 1	Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay Growth inhibition of human OVCAR3 cells after 48 hrs by SRB assay	[PMID: 24800942]
OVCAR-3	GI₅₀	0.22 μM Compound: 1	Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay Cytotoxicity against human OVCAR3 cells after 48 hrs by SRB assay	[PMID: 21823606]
OVCAR-3	GI₅₀	0.22 μM Compound: 1	Cytotoxicity against human OVCAR3 cells by SRB assay Cytotoxicity against human OVCAR3 cells by SRB assay	[PMID: 24502276]
OVCAR-3	GI₅₀	0.22 μM Compound: 1	Antiproliferative activity against human OVCAR3 cells by SRB assay Antiproliferative activity against human OVCAR3 cells by SRB assay	[PMID: 21710981]
OVCAR-3	GI₅₀	0.22 μM Compound: 2	Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
OVCAR-3	GI₅₀	0.22 μM Compound: 1	Antiproliferative activity against human OVCAR3 cells after 48 hrs Antiproliferative activity against human OVCAR3 cells after 48 hrs	[PMID: 27070999]
P388	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against camptothecin-resistant mouse P388 cells after 4 days by MTT method Cytotoxicity against camptothecin-resistant mouse P388 cells after 4 days by MTT method	[PMID: 19303306]
P388	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against mouse CPT45-resistant topoisomerase 1-deficient P388 cells after 4 days by MTT assay Cytotoxicity against mouse CPT45-resistant topoisomerase 1-deficient P388 cells after 4 days by MTT assay	[PMID: 18676151]
P388	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against camptothecin-resistant mouse P388 cells by MTT method Cytotoxicity against camptothecin-resistant mouse P388 cells by MTT method	[PMID: 18771930]
P388	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against mouse P388 cells after 4 days by MTT method Cytotoxicity against mouse P388 cells after 4 days by MTT method	[PMID: 19303306]
P388	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against mouse P388 cells after 4 days by MTT assay Cytotoxicity against mouse P388 cells after 4 days by MTT assay	[PMID: 19299037]
P388	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against mouse P388 cells by MTT method Cytotoxicity against mouse P388 cells by MTT method	[PMID: 18771930]
P388	IC₅₀	0.009 μM Compound: CPT	Cytotoxicity against mouse P388 cells after 4 days by MTT assay Cytotoxicity against mouse P388 cells after 4 days by MTT assay	[PMID: 18676151]
P388	IC₅₀	0.014 μM Compound: CPT	Cytotoxicity against mouse P388 cells after MTT assay Cytotoxicity against mouse P388 cells after MTT assay	[PMID: 18829334]
P388	IC₅₀	0.014 μM Compound: CPT	Cytotoxicity against mouse P388 cells by MTT method Cytotoxicity against mouse P388 cells by MTT method	[PMID: 19012996]
P388	IC₅₀	32.1 nM Compound: camptothecin	Cytotoxicity against mouse P388 cells after 72 hrs Cytotoxicity against mouse P388 cells after 72 hrs	[PMID: 17624792]
P388	IC₅₀	4.74 ng/mL Compound: 1a	Tested in vitro for the inhibition of P388 (mouse leukemia) cell line by MTT assay Tested in vitro for the inhibition of P388 (mouse leukemia) cell line by MTT assay	[PMID: 7932525]
P388CPT45	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against camptothecin-resistant and TOP1 deficient mouse P388/CPT45 cells after MTT assay Cytotoxicity against camptothecin-resistant and TOP1 deficient mouse P388/CPT45 cells after MTT assay	[PMID: 18829334]
P388CPT45	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against mouse P388/CPT45 cells after 4 days by MTT assay Cytotoxicity against mouse P388/CPT45 cells after 4 days by MTT assay	[PMID: 19299037]
PANC-1	IC₅₀	0.09 μM Compound: CPT	Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay Cytotoxicity against human PANC1 cells after 72 hrs by XTT assay	[PMID: 30017114]
PANC-1	IC₅₀	0.18 μM Compound: CPT	Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay Cytotoxicity against human PANC1 cells after 48 hrs by XTT assay	[PMID: 30017114]
PANC-1	GI₅₀	6.29 μM Compound: 1, CPT	Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PANC1 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
PBMC	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against human PBMC assessed as cell viability after 24 hrs by MTT assay Cytotoxicity against human PBMC assessed as cell viability after 24 hrs by MTT assay	[PMID: 24484281]
PC-3	GI₅₀	> 287 μM Compound: 1, CPT	Cytotoxicity against human PC3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human PC3 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
PC-3	IC₅₀	> 40 μM Compound: Camp	Induction of apoptosis in human PC3 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay Induction of apoptosis in human PC3 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay	[PMID: 29223099]
PC-3	IC₅₀	0.01 μM Compound: Camptothecin	Growth inhibition of human PC3 cells after 72 hrs by MTT assay Growth inhibition of human PC3 cells after 72 hrs by MTT assay	[PMID: 24180210]
PC-3	IC₅₀	0.03 μM Compound: Camptothecin	Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay Anticancer activity against human PC3 cells assessed as cell viability after 48 hrs by SRB assay	[PMID: 21074444]
PC-3	GI₅₀	0.06 μM Compound: Camptothecin	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21115210]
PC-3	GI₅₀	0.09 μM Compound: CPT	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 20662543]
PC-3	GI₅₀	0.09 μM Compound: 1, camptothecin	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 18180162]
PC-3	IC₅₀	0.1 μM Compound: CPT	Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as cell viability incubated for 72 hrs by MTT assay	[PMID: 25799376]
PC-3	IC₅₀	0.4 μM Compound: Camp	Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
PC-3	GI₅₀	0.48 μM Compound: 1	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 21388138]
PC-3	GI₅₀	0.7 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay	[PMID: 19715319]
PC-3	IC₅₀	1.2 μM Compound: Camptothecin	Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as cell viability after 48 hrs by MTT assay	10.1039/C4MD00344F
PC-3	IC₅₀	1.2 μM Compound: Camptothecin	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 24041234]
PC-3	IC₅₀	1.4 μM Compound: 1, CPT	Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay Cytotoxicity against p53-deficient human PC3 cells after 48 hrs by SRB assay	[PMID: 19715319]
PC-3	IC₅₀	12 nM Compound: 1a	Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay	[PMID: 21341674]
PC-3	IC₅₀	16.24 μM Compound: CPT	Cytotoxicity against human PC3 after 48 hrs by SRB assay Cytotoxicity against human PC3 after 48 hrs by SRB assay	[PMID: 21044847]
PC-3	ED₅₀	16.7 nM Compound: 3a, CPT, Camptothecin	Cytotoxicity against human PC3 cells by sulforhodamine B assay Cytotoxicity against human PC3 cells by sulforhodamine B assay	[PMID: 17350834]
PC-3	IC₅₀	18.24 μM Compound: Camptothecin	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 30109008]
PC-3	IC₅₀	2.4 μM Compound: CPT	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
PC-3	IC₅₀	2.5 μM Compound: CPT	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 26226379]
PC-3	IC₅₀	6.96 μM Compound: Camptothecin	Antiproliferative activity against human PC3 cells by MTT assay Antiproliferative activity against human PC3 cells by MTT assay	[PMID: 29131616]
PC-3	IC₅₀	78 nM Compound: CPT	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	[PMID: 24900725]
PC-3M	IC₅₀	0.19 μM Compound: Camptothecin	Anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as perinucleolar compartment disassembly and measured after 24 hrs by Hoechst 33342 staining based microscopic method Anticancer activity in human PC-3M cells expressing PTB/GFP fusion protein assessed as perinucleolar compartment disassembly and measured after 24 hrs by Hoechst 33342 staining based microscopic method	[PMID: 35696646]
PC-3M	IC₅₀	0.48 μM Compound: Camptothecin	Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level and measured after 24 to 48 hrs by ATPlite luminescence assay Cytotoxicity against human PC-3M cells expressing PTB/GFP fusion protein assessed as reduction in ATP level and measured after 24 to 48 hrs by ATPlite luminescence assay	[PMID: 35696646]
QG-56	IC₅₀	4.63 ng/mL Compound: 1a	Tested in vitro for the inhibition of QG-56 (human lung squamous cell carcinoma) cell line by MTT assay Tested in vitro for the inhibition of QG-56 (human lung squamous cell carcinoma) cell line by MTT assay	[PMID: 7932525]
Raji	IC₅₀	1 μM Compound: camptothecin	Cytotoxicity against human Raji cells by MTT assay Cytotoxicity against human Raji cells by MTT assay	[PMID: 20329739]
Raji	IC₅₀	3.27 μM Compound: Camptothecin	Cytotoxicity against human Raji cells after 48 hrs by MTT assay Cytotoxicity against human Raji cells after 48 hrs by MTT assay	[PMID: 30109008]
RD	IC₅₀	1.24 μM Compound: CPT	Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human TE32 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay	[PMID: 28923388]
RD	IC₅₀	1.24 μM Compound: CPT	Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay Cytotoxicity against human TE32 cells measured after 72 hrs by MTT assay	[PMID: 27721148]
RD	IC₅₀	1.72 μM Compound: CPT	Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against against human RD cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 30340899]
RD	IC₅₀	4.47 μM Compound: Camptothecin	Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay Cytotoxicity against human TE-32 cells after 72 hrs ny MTT assay	[PMID: 23974020]
RD	IC₅₀	4.49 μM Compound: Camptothecin	Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Cytotoxicity in human RD cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 28923382]
RKO	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human RKO cells measured after 72 hrs by MTT assay Antiproliferative activity against human RKO cells measured after 72 hrs by MTT assay	[PMID: 35462164]
RKO	IC₅₀	0.0617 μM Compound: CPT	Antiproliferative activity against human RKO cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human RKO cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 35868003]
RPMI 8402	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against human RPMI8402 cells after 4 days by MTT method Cytotoxicity against human RPMI8402 cells after 4 days by MTT method	[PMID: 19303306]
RPMI 8402	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay	[PMID: 19299037]
RPMI 8402	IC₅₀	0.004 μM Compound: CPT	Cytotoxicity against human RPMI8402 cells by MTT method Cytotoxicity against human RPMI8402 cells by MTT method	[PMID: 18771930]
RPMI 8402	IC₅₀	0.005 μM Compound: CPT	Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay Cytotoxicity against human RPMI8402 cells after 4 days by MTT assay	[PMID: 18676151]
RPMI 8402	IC₅₀	0.005 μM Compound: Camptothecin	Cytotoxic activity against human lymphoblast tumor cell line RPMI8402 after 4 days of treatment Cytotoxic activity against human lymphoblast tumor cell line RPMI8402 after 4 days of treatment	[PMID: 12747798]
RPMI 8402	IC₅₀	0.006 μM Compound: CPT	Cytotoxicity against human RPMI8402 cells after MTT assay Cytotoxicity against human RPMI8402 cells after MTT assay	[PMID: 18829334]
RPMI-7951	IC₅₀	0.22 μM Compound: CPT	Cytotoxicity against human RPMI7951 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human RPMI7951 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 32435422]
RPMI-8226	IC₅₀	0.006 μM Compound: CPT	Cytotoxicity against human RPMI8226 cells by MTT method Cytotoxicity against human RPMI8226 cells by MTT method	[PMID: 19012996]
RPMI-8226	IC₅₀	2.05 μg/mL Compound: Camptothecin	Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay Cytotoxicity against human RPMI8226 cells after 72 hrs by MTT assay	[PMID: 25867737]
SAOS-2	GI₅₀	> 287 μM Compound: 1, CPT	Cytotoxicity against human Saos2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human Saos2 cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
SAS	GI₅₀	6 μM Compound: CPT	Cytotoxicity against human SAS cells after 48 hrs by MTT assay Cytotoxicity against human SAS cells after 48 hrs by MTT assay	[PMID: 20662543]
SAS	GI₅₀	6 μM Compound: 1, camptothecin	Antiproliferative activity against human SAS cells after 48 hrs by MTT assay Antiproliferative activity against human SAS cells after 48 hrs by MTT assay	[PMID: 18180162]
SAS	IC₅₀	6 μM Compound: CPT	Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay Antiproliferative activity against human SAS cells incubated for 72 hrs by MTT assay	10.1039/C4MD00133H
SF-268	IC₅₀	0.04 μM Compound: Camptothecin	Cytotoxicity against human SF268 cells after 72 hrs by MTS assay Cytotoxicity against human SF268 cells after 72 hrs by MTS assay	[PMID: 21513293]
SF-268	EC₅₀	0.059 μM Compound: camptothecin	Cytotoxicity against human SF-268 after 3 days by SRB assay Cytotoxicity against human SF-268 after 3 days by SRB assay	[PMID: 15730238]
SF-268	IC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay Cytotoxicity against human SF268 cells incubated for 3 days by SRB assay	[PMID: 22863526]
SF-268	GI₅₀	0.19 μM Compound: CPT	Cytotoxicity against human SF268 cells after 72 hrs by XTT assay Cytotoxicity against human SF268 cells after 72 hrs by XTT assay	[PMID: 20591678]
SF-539	GI₅₀	< 0.01 μM Compound: 18	Cytotoxicity against human SF539 cells after 48 hrs by SRB assay Cytotoxicity against human SF539 cells after 48 hrs by SRB assay	[PMID: 28418653]
SF-539	GI₅₀	0.01 μM Compound: 1	Growth inhibition of human SF539 cells after 48 hrs by SRB assay Growth inhibition of human SF539 cells after 48 hrs by SRB assay	[PMID: 24800942]
SF-539	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human SF539 cells after 48 hrs by SRB assay Cytotoxicity against human SF539 cells after 48 hrs by SRB assay	[PMID: 21823606]
SF-539	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human SF539 cells by SRB assay Cytotoxicity against human SF539 cells by SRB assay	[PMID: 24502276]
SF-539	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human SF539 cells by SRB assay Antiproliferative activity against human SF539 cells by SRB assay	[PMID: 21710981]
SF-539	GI₅₀	0.01 μM Compound: 2	Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
SF-539	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human SF539 cells after 48 hrs Antiproliferative activity against human SF539 cells after 48 hrs	[PMID: 27070999]
Sf9	IC₅₀	0.025 μM Compound: CPT	Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis Poison activity at recombinant human TOP1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in relaxed supercoiled pBS(SK+) DNA mobility measured after 30 mins by ethidium bromide staining based agarose gel electrophoresis	[PMID: 30897325]
SGC-7901	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
SGC-7901	IC₅₀	5.8 μM Compound: CPT	Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay Antiproliferative activity against human SGC-7901 cells assessed as reduction in cell proliferation incubated for 48 hrs by MTT assay	[PMID: 35868003]
SH-SY5Y	IC₅₀	> 100 μM Compound: Camptothecin	Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 27344492]
SH-SY5Y	IC₅₀	0.61 μM Compound: CPT	Cytotoxicity against human SH-SY5Y cells expressing low level of topoisomerase I/II measured after 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells expressing low level of topoisomerase I/II measured after 72 hrs by MTT assay	[PMID: 35612499]
SiHa	GI₅₀	0.55 μM Compound: Camptothecin	Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
SK-BR-3	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human SKBR3 cells after 3 days by SRB assay Cytotoxicity against human SKBR3 cells after 3 days by SRB assay	[PMID: 23142674]
SK-BR-3	GI₅₀	0.15 μM Compound: Camptothecin	Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay Antiproliferative activity against estrogen receptor deficient human SKBR3 cells after 48 hrs by SRB assay	[PMID: 20438092]
SK-BR-3	IC₅₀	0.21 μM Compound: CPT	Cytotoxicity against HER-positive human SK-BR-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against HER-positive human SK-BR-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36351049]
SK-HEP1	IC₅₀	0.9 μM Compound: CPT	Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay Antiproliferative activity against human SKHEP1 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay	[PMID: 31880942]
SK-HEP1	IC₅₀	0.96 μM Compound: CPT	Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay Cytotoxicity against human SKHEP1 cells after 72 hrs by MTT assay	[PMID: 26226379]
SK-MEL	GI₅₀	0.047 μM Compound: 1	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT assay	[PMID: 21388138]
SK-MEL-2	IC₅₀	0.075 μM Compound: CPT, campothecin	Cytotoxicity against human SK-MEL-2 cells by SRB assay Cytotoxicity against human SK-MEL-2 cells by SRB assay	[PMID: 17827007]
SK-MEL-2	IC₅₀	0.165 μM Compound: camptothecin	Cytotoxicity against human SK-MEL-2 cells after 48 hrs Cytotoxicity against human SK-MEL-2 cells after 48 hrs	[PMID: 17673337]
SK-MEL-2	IC₅₀	6.88 μg/mL Compound: CPT	Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells by sulforhodamine B assay	[PMID: 21684168]
SK-MEL-2	IC₅₀	7.86 μM Compound: CPT	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by MTT assay	[PMID: 21873069]
SK-MEL-24	IC₅₀	0.46 μM Compound: CPT	Cytotoxicity against human SK-MEL-24 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against human SK-MEL-24 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 32435422]
SK-MEL-28	IC₅₀	< 0.01 μM Compound: Camptothecin	Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay Growth inhibition of human SK-MEL-28 cells after 72 hrs by MTT assay	[PMID: 24180210]
SK-MEL-28	IC₅₀	0.04 μM Compound: CPT	Antiproliferative activity against human SK-MEL-28 cells by MTT assay Antiproliferative activity against human SK-MEL-28 cells by MTT assay	[PMID: 17254669]
SK-MEL-28	CC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay	[PMID: 22884523]
SK-MEL-28	CC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells after 96 hrs by MTT assay	[PMID: 22047799]
SK-MEL-28	IC₅₀	2.26 μM Compound: CPT	Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human SK-MEL-28 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35635947]
SK-MES-1	IC₅₀	0.01 μM Compound: CPT	Antiproliferative activity against human SKMES1 cells by MTT assay Antiproliferative activity against human SKMES1 cells by MTT assay	[PMID: 17254669]
SK-MES-1	CC₅₀	0.03 μM Compound: Camptothecin	Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay	[PMID: 22047799]
SK-MES-1	CC₅₀	0.05 μM Compound: Camptothecin	Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay Cytotoxicity against human SKMES1 cells after 96 hrs by MTT assay	[PMID: 22884523]
SK-OV-3	IC₅₀	0.014 μM Compound: camptothecin	Cytotoxicity against human SK-OV3 cells after 48 hrs Cytotoxicity against human SK-OV3 cells after 48 hrs	[PMID: 17673337]
SK-OV-3	IC₅₀	0.051 μM Compound: Camptothecin	Inhibitory concentration the viability of SKOV 3 cell population by 50%. Inhibitory concentration the viability of SKOV 3 cell population by 50%.	[PMID: 9003520]
SK-OV-3	IC₅₀	1.54 μg/mL Compound: CPT	Cytotoxicity against human SKOV3 cells by sulforhodamine B assay Cytotoxicity against human SKOV3 cells by sulforhodamine B assay	[PMID: 21684168]
SK-OV-3	IC₅₀	2.544 μM Compound: CPT	Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay Cytotoxicity against human SKOV3 cells after 48 hrs by MTT assay	[PMID: 21873069]
SK-OV-3	IC₅₀	2.56 μM Compound: Camptothecin	Antitumor activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
SK-OV-3	IC₅₀	3.82 μM Compound: CPT	Cytotoxicity against HER-positive human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay Cytotoxicity against HER-positive human SK-OV-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay	[PMID: 36351049]
SK-OV-3	IC₅₀	37 nM Compound: 1	Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay Cytotoxicity was determined in vitro in SK-OV-3 cells (ovarian) of human tumor cell lines by using MTT assay	[PMID: 7853331]
SK-OV-3	IC₅₀	4.86 μM Compound: Camptothecin	Antitumor activity against taxol-resistant human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against taxol-resistant human SK-OV-3 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
SK-OV-3	IC₅₀	5.5 nM Compound: CPT	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 analysis	[PMID: 34952177]
SK-OV-3	IC₅₀	5.5 nM Compound: CPT	Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay Antiproliferative activity against human SK-OV-3 cells assessed as cell growth inhibition measured after 48 hrs by CCK-8 assay	[PMID: 33962152]
SK-OV-3	IC₅₀	5.5 nM Compound: I; CPT	Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SKOV3 cells incubated for 48 hrs by CCK8 assay	[PMID: 31229877]
SK-OV-3	IC₅₀	5.5 nM Compound: CPT	Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay Antiproliferative activity against human SKOV3 cells after 48 hrs by CCK-8 assay	[PMID: 29501943]
SK-OV-3	IC₅₀	5.5 nM Compound: Camptothecin	Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay Cytotoxicity against human SKOV3 cells assessed as growth inhibition after 48 hrs by CCK8 assay	[PMID: 27017547]
SK-OV-3	IC₅₀	5.5 μM Compound: I; CPT	Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 48 hrs by CCK8 assay	[PMID: 32279049]
SK-VLB	IC₅₀	0.053 μM Compound: Camptothecin	Inhibitory concentration that reduced the viability of SKVLB cell population by 50%. Inhibitory concentration that reduced the viability of SKVLB cell population by 50%.	[PMID: 9003520]
SK-VLB	IC₅₀	41 nM Compound: 1	Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay Cytotoxicity was determined in vitro in SKVLB cells(ovarian with upregulated MDRp-glycoprotein) of human tumor cell lines by using MTT assay	[PMID: 7853331]
SMMC-7721	IC₅₀	> 10 μM Compound: CPT	Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 34852457]
SMMC-7721	IC₅₀	0.003 μM Compound: camptothecin	Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay Cytotoxicity against human SMMC7721 cells after 48 hrs by SRB assay	[PMID: 21973054]
SMMC-7721	IC₅₀	0.02 μM Compound: CPT	Cytotoxicity against human SMMC7721 after 48 hrs by SRB assay Cytotoxicity against human SMMC7721 after 48 hrs by SRB assay	[PMID: 21044847]
SMMC-7721	IC₅₀	0.45 μM Compound: CPT; 1	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 30509782]
SMMC-7721	IC₅₀	1.08 μM Compound: CPT	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay	[PMID: 30125725]
SN12C	GI₅₀	0.02 μM Compound: 18	Cytotoxicity against human SN12C cells after 48 hrs by SRB assay Cytotoxicity against human SN12C cells after 48 hrs by SRB assay	[PMID: 28418653]
SN12C	GI₅₀	0.02 μM Compound: 1	Growth inhibition of human SN12C cells after 48 hrs by SRB assay Growth inhibition of human SN12C cells after 48 hrs by SRB assay	[PMID: 24800942]
SN12C	GI₅₀	0.02 μM Compound: 1	Cytotoxicity against human SN12C cells after 48 hrs by SRB assay Cytotoxicity against human SN12C cells after 48 hrs by SRB assay	[PMID: 21823606]
SN12C	GI₅₀	0.02 μM Compound: 1	Cytotoxicity against human SN12C cells by SRB assay Cytotoxicity against human SN12C cells by SRB assay	[PMID: 24502276]
SN12C	GI₅₀	0.02 μM Compound: 1	Antiproliferative activity against human SN12C cells by SRB assay Antiproliferative activity against human SN12C cells by SRB assay	[PMID: 21710981]
SN12C	GI₅₀	0.02 μM Compound: 2	Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
SN12C	GI₅₀	0.02 μM Compound: 1	Antiproliferative activity against human SN12C cells after 48 hrs Antiproliferative activity against human SN12C cells after 48 hrs	[PMID: 27070999]
SNU-475	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay Cytotoxicity against human SNU475 cells assessed as growth inhibition after 72 hrs by sulforhodamine B assay	[PMID: 26810835]
SNU-638	IC₅₀	0.098 μM Compound: CPT	Cytotoxicity against human SNU638 cells by MTT assay Cytotoxicity against human SNU638 cells by MTT assay	[PMID: 21353568]
SNU-638	IC₅₀	0.098 μM Compound: camptothecin	Cytotoxicity against human SNU638 cells by SRB assay Cytotoxicity against human SNU638 cells by SRB assay	[PMID: 17498951]
SNU-638	IC₅₀	0.28 μM Compound: Camptothecin	Cytotoxicity against human SNU638 cells by MTT assay Cytotoxicity against human SNU638 cells by MTT assay	[PMID: 23608763]
Splenocyte	CC₅₀	0.62 μM Compound: CPT	Cytotoxicity against BALB/c mouse splenocytes assessed as cell viability after 48 hrs by alamar blue assay Cytotoxicity against BALB/c mouse splenocytes assessed as cell viability after 48 hrs by alamar blue assay	[PMID: 27639365]
SU-DHL-2	IC₅₀	0.94 μM Compound: Camptothecin	Antitumor activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human SUDHL2 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
SW1573	GI₅₀	0.21 μM Compound: CPT	Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SW1573 cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
SW1573	GI₅₀	0.25 μM Compound: Camptothecin	Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay Antiproliferative activity against human SW1573 cells after 48 hrs by SRB assay	[PMID: 23831507]
SW1990	IC₅₀	0.2 μM Compound: CPT	Antitumor activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antitumor activity against human SW1990 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 32668379]
SW480	IC₅₀	0.21 μM Compound: Camptothecin	Antiproliferation activity against human SW480 cells assessed as reduction in cell viability measured after 72 hours by MTT assay Antiproliferation activity against human SW480 cells assessed as reduction in cell viability measured after 72 hours by MTT assay	[PMID: 32201190]
SW480	IC₅₀	0.29 μM Compound: CPT; 1	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 30509782]
SW-620	EC₅₀	0.0021 μM Compound: Cpt, camptothecin	Antiproliferative activity against human SW620 cells by soft agar assay Antiproliferative activity against human SW620 cells by soft agar assay	[PMID: 17287122]
SW626	IC₅₀	28.7 nM Compound: Camptothecin	Cytotoxicity against human SW626 cells by MTT assay Cytotoxicity against human SW626 cells by MTT assay	[PMID: 11858760]
SW948	IC₅₀	0.16 μM Compound: CPT	Antiproliferative activity against human SW948 cells after 3 days by XTT assay Antiproliferative activity against human SW948 cells after 3 days by XTT assay	[PMID: 19691293]
T-24	IC₅₀	0.006 μM Compound: camptothecin	Growth inhibition of human T24 cells by neutral red assay Growth inhibition of human T24 cells by neutral red assay	[PMID: 17204425]
T-24	IC₅₀	3.09 μM Compound: CPT	Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human T24 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 30875505]
T-24	IC₅₀	6.8 μM Compound: CPT	Antiproliferative activity against human T24 cells after 48 hrs by MTT assay Antiproliferative activity against human T24 cells after 48 hrs by MTT assay	[PMID: 30685528]
T-24	IC₅₀	88 nM Compound: 1, CPT, NSC-100880	Cytotoxicity against human chemo-resistant T24 cells by WST assay Cytotoxicity against human chemo-resistant T24 cells by WST assay	[PMID: 23578545]
T-24	IC₅₀	88 nM Compound: CPT	Cytotoxicity against T24 tumor cell line determined by WST-1 assay Cytotoxicity against T24 tumor cell line determined by WST-1 assay	[PMID: 10841808]
T47D	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human T47D cells after 3 days by SRB assay Cytotoxicity against human T47D cells after 3 days by SRB assay	[PMID: 23142674]
T47D	IC₅₀	< 1 μM Compound: CPT	Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay Cytotoxicity against human T47D cells incubated for 72 hrs by SRB assay	[PMID: 22867707]
T47D	IC₅₀	0.07 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells incubated for 72 hrs by CCK8 assay	[PMID: 29402741]
T47D	IC₅₀	0.07 μM Compound: Camptothecin	Cytotoxicity against human T47D cells by MTT assay Cytotoxicity against human T47D cells by MTT assay	[PMID: 23608763]
T47D	IC₅₀	0.07 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay Antiproliferative activity against human T47D cells after 72 hrs by EZ-CYTOX reagent based assay	[PMID: 30262132]
T47D	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 2 days by CCK8 assay Cytotoxicity against human T47D cells after 2 days by CCK8 assay	[PMID: 26361737]
T47D	IC₅₀	0.08 μM Compound: Camptothecin	Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay Cytotoxicity against human T47D cells assessed as reduction in cell growth after 72 hrs by CCK8 assay	[PMID: 27484510]
T47D	IC₅₀	0.09 μM Compound: CPT	Antiproliferative activity against human T47D cells after 72 hrs by EZ-Cytox colorimetric assay Antiproliferative activity against human T47D cells after 72 hrs by EZ-Cytox colorimetric assay	[PMID: 34678573]
T47D	IC₅₀	0.25 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay	[PMID: 31398033]
T47D	IC₅₀	0.28 μM Compound: CPT	Cytotoxicity against human T47D cells after 2 days Cytotoxicity against human T47D cells after 2 days	[PMID: 24904965]
T47D	IC₅₀	0.3 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 2 days by CCK-8 assay Cytotoxicity against human T47D cells after 2 days by CCK-8 assay	[PMID: 24013413]
T47D	IC₅₀	0.31 μM Compound: Camptothecin	Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay Cytotoxicity against human T47D cells incubated from day 2 to day 4 by CCK8 assay	[PMID: 26022080]
T47D	IC₅₀	0.49 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK-8 assay	[PMID: 29510948]
T47D	IC₅₀	0.59 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells measured after 72 hrs by CCK8 assay	[PMID: 27654394]
T47D	IC₅₀	0.75 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 4 days by CCK-8 assay Cytotoxicity against human T47D cells after 4 days by CCK-8 assay	[PMID: 25062006]
T47D	IC₅₀	1.53 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis Cytotoxicity against human T47D cells after 2 days by cell counting kit-8 analysis	[PMID: 22503656]
T47D	IC₅₀	1.62 μM Compound: CPT	Cytotoxicity against human T47D cells measured after 2 days by MTT assay Cytotoxicity against human T47D cells measured after 2 days by MTT assay	[PMID: 26334499]
T47D	IC₅₀	1.84 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay Cytotoxicity against human T47D cells after 48 hrs by CCK8 assay	[PMID: 26945111]
T47D	IC₅₀	1.84 μM Compound: camptothecin	Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay Cytotoxicity against human T47D cells measured on day 4 by CCK8 assay	[PMID: 25936262]
T47D	GI₅₀	1.9 μM Compound: CPT	Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay Growth inhibition of human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
T47D	IC₅₀	11.17 μM Compound: Camptothecin	Cytotoxicity against human T47D cells after 3 days by CCK8 assay Cytotoxicity against human T47D cells after 3 days by CCK8 assay	[PMID: 26927425]
T47D	IC₅₀	13.7 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 27643560]
T47D	GI₅₀	2 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 48 hrs by SRB assay Antiproliferative activity against human T47D cells after 48 hrs by SRB assay	[PMID: 23831507]
T47D	GI₅₀	2 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay Antiproliferative activity against human T47D cells expressing estrogen receptor after 48 hrs by SRB assay	[PMID: 20438092]
T47D	IC₅₀	2.1 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 28384547]
T47D	IC₅₀	2.1 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 28068603]
T47D	IC₅₀	2.31 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 28633898]
T47D	IC₅₀	207 nM Compound: 1	Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay Cytotoxicity was determined in vitro in T47D cells(breast) of human tumor cell lines by using MTT assay	[PMID: 7853331]
T47D	IC₅₀	3.67 μM Compound: Camptothecin	Cytotoxicity against human T47D cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay Cytotoxicity against human T47D cells assessed as cell growth inhibition measured after 2 days by cell counting kit-8 assay	[PMID: 27707625]
T47D	IC₅₀	4.1 μM Compound: Camptothecin	Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay Antiproliferative activity against human T47D cells after 72 hrs by CCK8 assay	[PMID: 26988802]
T47D	IC₅₀	9.17 μM Compound: CPT	Cytotoxicity against human T47D cells after 72 hrs by MTT assay Cytotoxicity against human T47D cells after 72 hrs by MTT assay	[PMID: 22819942]
TERT-RPE1	IC₅₀	> 40 μM Compound: Camp	Cytotoxicity against human RPE1 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay Cytotoxicity against human RPE1 cells assessed as reduction in cell viability after 48 hrs by ATPlite-based luminescent assay	[PMID: 29223099]
TERT-RPE1	IC₅₀	27.2 μM Compound: Camp	Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay Induction of apoptosis in human RPE1 cells assessed as caspase 3/7 activity after 24 hrs by caspase-glo luminescent assay	[PMID: 29223099]
THP-1	IC₅₀	0.071 μM Compound: Camptothecin	Cytotoxicity against human THP1 cells after 2 days by MTT assay Cytotoxicity against human THP1 cells after 2 days by MTT assay	[PMID: 22325897]
THP-1	EC₅₀	0.16 μM Compound: camptothecin	Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method Cytotoxicity against human THP1 cells after 72 hrs by erythosin B staining method	[PMID: 20192247]
THP-1	IC₅₀	0.6 μM Compound: 1, CPT	Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay Cytotoxicity against human THP1 cells expressing p53 mutant after 48 hrs by SRB assay	[PMID: 19715319]
THP-1	IC₅₀	1.89 μM Compound: Camptothecin	Antitumor activity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
U-251	GI₅₀	0.01 μM Compound: Camptothecin	Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay Antiproliferative activity against human U-251 cells assessed as reduction in cell viability incubated for 48 hrs by sulphorhodamine B assay	[PMID: 29313676]
U2OS	GI₅₀	> 287 μM Compound: 1, CPT	Cytotoxicity against human U2OS cells incubated for 72 hrs by MTT assay Cytotoxicity against human U2OS cells incubated for 72 hrs by MTT assay	[PMID: 22867019]
U-373MG ATCC	IC₅₀	0.015 μM Compound: Camptothecin	Growth inhibition of human U373 cells after 72 hrs by MTT assay Growth inhibition of human U373 cells after 72 hrs by MTT assay	[PMID: 24180210]
U-373MG ATCC	GI₅₀	0.033 μM Compound: 1	Cytotoxicity against human U373 cells after 72 hrs by MTT assay Cytotoxicity against human U373 cells after 72 hrs by MTT assay	[PMID: 21388138]
U-87MG ATCC	IC₅₀	< 1.85 μM Compound: CPT	Antiproliferative activity against human U87 cells measured after 72 hrs by MTT assay Antiproliferative activity against human U87 cells measured after 72 hrs by MTT assay	[PMID: 35462164]
U-87MG ATCC	IC₅₀	0.5 μM Compound: Camptothecin	Cytotoxicity against human U87 cells after 72 hrs by MTT assay Cytotoxicity against human U87 cells after 72 hrs by MTT assay	[PMID: 21186067]
U-937	IC₅₀	0.015 μM Compound: camptothecin	Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	0.032 μM Compound: camptothecin	Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	0.3 μM Compound: 1, CPT	Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay Cytotoxicity against human U937 cells expressing p53 mutant after 48 hrs by SRB assay	[PMID: 19715319]
U-937	IC₅₀	0.68 μM Compound: camptothecin	Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay	[PMID: 17158054]
U-937	IC₅₀	1.81 μM Compound: Camptothecin	Antitumor activity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs Antitumor activity against human U-937 cells assessed as reduction in cell viability incubated for 72 hrs	[PMID: 36906964]
U-937	IC₅₀	1.98 μM Compound: Camptothecin	Cytotoxicity against human U937 cells after 2 days by MTT assay Cytotoxicity against human U937 cells after 2 days by MTT assay	[PMID: 22325897]
UACC-62	GI₅₀	< 0.01 μM Compound: 18	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay	[PMID: 28418653]
UACC-62	GI₅₀	0.01 μM Compound: 1	Growth inhibition of human UACC62 cells after 48 hrs by SRB assay Growth inhibition of human UACC62 cells after 48 hrs by SRB assay	[PMID: 24800942]
UACC-62	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay	[PMID: 21823606]
UACC-62	GI₅₀	0.01 μM Compound: 1	Cytotoxicity against human UACC62 cells by SRB assay Cytotoxicity against human UACC62 cells by SRB assay	[PMID: 24502276]
UACC-62	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human UACC62 cells by SRB assay Antiproliferative activity against human UACC62 cells by SRB assay	[PMID: 21710981]
UACC-62	GI₅₀	0.01 μM Compound: 2	Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 22329436]
UACC-62	GI₅₀	0.01 μM Compound: 1	Antiproliferative activity against human UACC62 cells after 48 hrs Antiproliferative activity against human UACC62 cells after 48 hrs	[PMID: 27070999]
Vero	IC₅₀	0.02 μg/mL Compound: camptothecin	Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay Cytotoxicity against african green monkey Vero cells after 7 days by XTT assay	[PMID: 8021652]
Vero	IC₅₀	58 μg/mL Compound: Camptothecin	Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells by MTT assay Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells by MTT assay	10.1007/s00044-010-9381-7
WI-38	IC₅₀	0.03 μg/mL Compound: camptothecin	Cytotoxicity against human WI38 cells assessed as cell viability by WST-1 assay Cytotoxicity against human WI38 cells assessed as cell viability by WST-1 assay	[PMID: 24593048]
WI-38	IC₅₀	0.03 μM Compound: Camptothecin	Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay Cytotoxicity against human WI38 cells after 48 hrs by WST-1 assay	[PMID: 28557449]
WI-38	IC₅₀	0.23 μM Compound: Campthotecin	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 26063305]
WI-38	IC₅₀	0.4 μg/mL Compound: Camptothecin	Cytotoxicity against human WI38 cells by MTT assay Cytotoxicity against human WI38 cells by MTT assay	[PMID: 23816880]
WI-38	IC₅₀	786 nM Compound: CPT	Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay Cytotoxicity against human WI38 cells overexpressing biotin receptor assessed as growth inhibition after 72 hrs by MTT assay	[PMID: 24901491]
WI-38	IC₅₀	8.37 μM Compound: CPT	Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay Antiproliferative activity against human WI38 cells after 48 hrs by MTT assay	[PMID: 30685528]
WiDr	IC₅₀	0.07 μg/mL Compound: camptothecin	Cytotoxicity against human WiDr cells by MTT assay Cytotoxicity against human WiDr cells by MTT assay	[PMID: 18774864]
WiDr	ED₅₀	0.07 μg/mL Compound: Camptothecin	Cytotoxicity against human WiDr cells by MTT assay Cytotoxicity against human WiDr cells by MTT assay	[PMID: 18220355]
WiDr	GI₅₀	1.7 μM Compound: CPT	Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay Growth inhibition of human WiDr cells after 48 hrs by sulforhodamine B assay	[PMID: 19664930]
WiDr	GI₅₀	1.8 μM Compound: Camptothecin	Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay Antiproliferative activity against human WiDr cells after 48 hrs by SRB assay	[PMID: 23831507]
WIL2-NS	CC₅₀	0.005 μM Compound: Camptothecin	Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay	[PMID: 22884523]
WIL2-NS	CC₅₀	0.005 μM Compound: Camptothecin	Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay Cytotoxicity against human WIL2-NS cells after 96 hrs by MTT assay	[PMID: 22047799]
WIL2-NS	IC₅₀	0.005 μM Compound: CPT	Antiproliferative activity against human WIL-2NS cells by MTT assay Antiproliferative activity against human WIL-2NS cells by MTT assay	[PMID: 17254669]
ZR-75-1	IC₅₀	< 0.01 μM Compound: CPT	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 23142674]
ZR-75-30	IC₅₀	0.24 μM Compound: CPT	Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay Antiproliferative activity against human ZR-7530 cells after 72 hrs by MTT assay	[PMID: 28351590]

In Vitro

High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward Camptothecin (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC₅₀ values of 0.089 μM and 0.067 μM, respectively^[4].
Camptothecin (0.5 μM; 6 and 24 hours) reduces desferrioxamine-activated VEGF expression.
Camptothecin (0.5 μM; 8 to 24 hours) strongly prevents the desferrioxamine-dependent HIF-1a accumulation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:	MCF7 (Luminal subtype) and HCC1419 (HER2 subtype)
Concentration:	0.1 μM to 5 μM
Incubation Time:	72 hours
Result:	High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward CPT (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC₅₀ values of 0.089 μM and 0.067 μM, respectively.

RT-PCR^[2]

Cell Line:	HeLa and HEK293 cell lines
Concentration:	0.5 μmol/L
Incubation Time:	6 and 24 hours
Result:	Reduces desferrioxamine-activated VEGF expression in both cell lines after 6 and 24 hours of treatment, whereas in normoxic condition camptothecin does not affect the VEGF mRNA level.

Western Blot Analysis^[2]

Cell Line:	HeLa and HEK293 cell lines
Concentration:	0.5 μmol/L
Incubation Time:	8 to 24 hours
Result:	Strongly prevents the desferrioxamine-dependent HIF-1a accumulation after 8 to 24 hours, whereas it does not affect HIF-1b levels.

In Vivo

Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases.
Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL6 mice (injected with B16F10 melanoma cells)^[5]
Dosage:	2 mg/kg
Administration:	every other day, after 19 days
Result:	Has developed numerous pulmonary metastases.

Clinical Trial

Molecular Weight

348.35

Formula

C₂₀H₁₆N₂O₄

CAS No.

7689-03-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

Solvent & Solubility

In Vitro:

1M NaOH : 10 mg/mL (28.71 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : 6.25 mg/mL (17.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8707 mL	14.3534 mL	28.7068 mL
5 mM	0.5741 mL	2.8707 mL	5.7414 mL
10 mM	0.2871 mL	1.4353 mL	2.8707 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (protect from light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 10 mg/mL (28.71 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (287 KB) SDS (644 KB)

COA (259 KB) HNMR (251 KB) RP-HPLC (242 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Luzzio MJ, et al. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. Synthesis and antitumor activity of novel water soluble derivatives of camptothecin as specific inhibitors of topoisomerase I. [Content Brief]

[2]. Bertozzi D, et al. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells. Mol Cancer Ther. 2014;13(1):239-248. [Content Brief]

[3]. Huang Q, et al. Evolution in medicinal chemistry of E-ring-modified Camptothecin analogs as anticancer agents. Eur J Med Chem. 2013;63:746-757. [Content Brief]

[4]. Tesauro C, et al. Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study. BMC Cancer. 2019;19(1):1158. Published 2019 Nov 29. [Content Brief]

[5]. Schön M, et al. KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment. J Natl Cancer Inst. 2008;100(12):862-875.. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / 1M NaOH	1 mM	2.8707 mL	14.3534 mL	28.7068 mL	71.7669 mL
	5 mM	0.5741 mL	2.8707 mL	5.7414 mL	14.3534 mL
	10 mM	0.2871 mL	1.4353 mL	2.8707 mL	7.1767 mL
	15 mM	0.1914 mL	0.9569 mL	1.9138 mL	4.7845 mL
1M NaOH	20 mM	0.1435 mL	0.7177 mL	1.4353 mL	3.5883 mL
1M NaOH	25 mM	0.1148 mL	0.5741 mL	1.1483 mL	2.8707 mL

Camptothecin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Camptothecin (Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT)

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Camptothecin (Synonyms: Campathecin; (S)-(+)-Camptothecin; CPT)

Customer Review

Other Forms of Camptothecin:

Camptothecin Related Antibodies

39 Publications Citing Use of MCE Camptothecin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Topoisomerase Isoform Specific Products:

View All ADC Cytotoxin Isoform Specific Products:

View All Antibiotic Isoform Specific Products:

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Purity & Documentation

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Camptothecin Related Antibodies

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Complete Stock Solution Preparation Table

Camptothecin Related Classifications

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