Trandolaprilate hydrate  (Synonyms: Trandolaprilat hydrate; RU 44403 hydrate)

Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity^[1][2].

420.50

C₂₂H₃₂N₂O₆

951393-55-8

Solid

White to off-white

O=C([C@H]1N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)[C@@]3([H])CCCC[C@]3([H])C1)O.O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517.  [Content Brief]

  [2]. Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72.  [Content Brief]