trans-4-Hydroxy-2-nonenoic acid

Name: trans-4-Hydroxy-2-nonenoic acid
Brand: MedChemExpress
SKU: HY-N10923
Rating: 4.5 (1 reviews)

Cat. No.: HY-N10923 Purity: 98.64%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

trans-4-Hydroxy-2-nonenoic acid (compound 4) is a nature product that could be isolated from the genus Pottsia.

For research use only. We do not sell to patients.

trans-4-Hydroxy-2-nonenoic acid Chemical Structure

CAS No. : 95087-42-6

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

trans-4-Hydroxy-2-nonenoic acid (compound 4) is a nature product that could be isolated from the genus Pottsia^[1].

Molecular Weight

172.22

Formula

C₉H₁₆O₃

CAS No.

95087-42-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(/C=C/C(CCCCC)O)O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (580.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.8065 mL	29.0326 mL	58.0653 mL
5 mM	1.1613 mL	5.8065 mL	11.6131 mL
10 mM	0.5807 mL	2.9033 mL	5.8065 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 7 mg/mL (40.65 mM); Clear solution

This protocol yields a clear solution of ≥ 7 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (70.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 7 mg/mL (40.65 mM); Clear solution

This protocol yields a clear solution of ≥ 7 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (70.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.64%

Select Batch:

Data Sheet (267 KB) SDS (252 KB)

COA (242 KB) HNMR (248 KB) RP-HPLC (262 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Hua ML, et, al. Chemical constituents of the roots of Pottsia laxiflora. Chemistry of Natural Compounds volume. 2013 Feb 17;48:1004-7.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.8065 mL	29.0326 mL	58.0653 mL	145.1632 mL
	5 mM	1.1613 mL	5.8065 mL	11.6131 mL	29.0326 mL
	10 mM	0.5807 mL	2.9033 mL	5.8065 mL	14.5163 mL
	15 mM	0.3871 mL	1.9355 mL	3.8710 mL	9.6775 mL
	20 mM	0.2903 mL	1.4516 mL	2.9033 mL	7.2582 mL
	25 mM	0.2323 mL	1.1613 mL	2.3226 mL	5.8065 mL
	30 mM	0.1936 mL	0.9678 mL	1.9355 mL	4.8388 mL
	40 mM	0.1452 mL	0.7258 mL	1.4516 mL	3.6291 mL
	50 mM	0.1161 mL	0.5807 mL	1.1613 mL	2.9033 mL
	60 mM	0.0968 mL	0.4839 mL	0.9678 mL	2.4194 mL
	80 mM	0.0726 mL	0.3629 mL	0.7258 mL	1.8145 mL
	100 mM	0.0581 mL	0.2903 mL	0.5807 mL	1.4516 mL