2. Antibody-drug Conjugate/ADC Related JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. Antibody-Drug Conjugates (ADCs) EGFR
  4. Trastuzumab deruxtecan (solution)

Trastuzumab deruxtecan (solution)  (Synonyms: DS-8201 (solution); DS-8201a (solution))

Cat. No.: HY-138298 Purity: 99.64%
SDS COA Handling Instructions Technical Support

Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer.

For research use only. We do not sell to patients.

Trastuzumab deruxtecan (solution) Chemical Structure

Trastuzumab deruxtecan (solution) Chemical Structure

CAS No. : 1826843-81-5

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1 mg (10 mg/mL * 100 μL in Aqueous solution) In-stock
Solvent
5 mg (10 mg/mL * 500 μL in Aqueous solution) In-stock
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Based on 2 publication(s) in Google Scholar

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Trastuzumab deruxtecan (solution) Related Antibodies

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Description

Trastuzumab deruxtecan (T-DXd; DS-8201a) (solution) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugate (ADC). Trastuzumab deruxtecan is composed of a humanized anti-HER2 antibody, an enzymatically cleavable peptide-linker, a topoisomerase I inhibitor (a toxin component of Dxd). Trastuzumab deruxtecan can be used for the research of HER2-positive breast cancer and gastric cancer[1][2].

In Vitro

Trastuzumab deruxtecan (1 pM-10 nM; 5 days) (solution) inhibits the growth of HER2-positive KPL-4 cells, with an IC50 of 109.7 pM[2].
Trastuzumab deruxtecan (10 nM; 5 days) (solution) shows bystander killing effects in HER2-negative MDA-MB-468 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Trastuzumab deruxtecan (solution) Related Antibodies

Cell Viability Assay[2]

Cell Line: KPL-4 and MDA-MB-468 cells
Concentration: 1, 10, 100, 1000, 10000 pM
Incubation Time: 5 days
Result: Killed HER2-positive KPL-4 cells only.
In Vivo

Trastuzumab deruxtecan (3 mg/kg; a single i.v.) (solution) shows antitumor activity against not only HER2-positive tumors but also HER2-negative tumors under the co-inoculated condition[2].
Trastuzumab deruxtecan (10 mg/kg; i.v. on days 0 and 7) (solution) inhibits the tumor growth in in EMT6-hHER2 syngeneic mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice injected with NCI-N87 and MDA-MB-468-Luc cells[2]
Dosage: 3 mg/kg
Administration: A single i.v.
Result: Almost all of the HER2-positive and HER-negative cells disappeared and there were little or no cancer cells remaining in the tumors.
Clinical Trial
Molecular Weight

153000 (average)

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Trastuzumab deruxtecan]
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light
Purity & Documentation

Purity: 99.64%

SDS (251 KB)

COA (232 KB) Others (357 KB) SEC-HPLC (371 KB)

Handling Instructions (2659 KB)
References
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Trastuzumab deruxtecan (solution) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trastuzumab deruxtecan (solution)1826843-81-5DS-8201 (solution) DS-8201a (solution)Antibody-Drug Conjugates (ADCs)EGFRAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1humanepidermalgrowthfactorHER2antibody-drugconjugateADCantitumorcancerInhibitorinhibitorinhibit

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