Triamcinolone acetonide-d₆

Name: Triamcinolone acetonide-d 6
Brand: MedChemExpress
SKU: HY-B0636S3
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0636S3 Purity: 98.04%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Triamcinolone acetonide-d₆ is deuterium labeled Triamcinolone acetonide.

For research use only. We do not sell to patients.

Triamcinolone acetonide-d<sub>6</sub> Chemical Structure

Triamcinolone acetonide-d₆ Chemical Structure

CAS No. : 352431-33-5

Size	Price	Stock	Quantity
1 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Triamcinolone acetonide-d₆:

Triamcinolone acetonide In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Triamcinolone acetonide-d₆ is deuterium labeled Triamcinolone acetonide.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

440.53

Formula

C₂₄H₂₅D₆FO₆

CAS No.

352431-33-5

Unlabeled CAS

76-25-5

Appearance

Solid

Color

White to off-white

SMILES

OCC([C@]12[C@@]3([C@@]([C@@]4([H])[C@]([C@H](C3)O)([C@@]5(C(CC4)=CC(C=C5)=O)C)F)([H])C[C@@]1([H])OC(O2)(C([2H])([2H])[2H])C([2H])([2H])[2H])C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (113.50 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2700 mL	11.3500 mL	22.6999 mL
5 mM	0.4540 mL	2.2700 mL	4.5400 mL
10 mM	0.2270 mL	1.1350 mL	2.2700 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.04%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (259 KB) HNMR (280 KB) RP-HPLC (3616 KB)

Handling Instructions (2659 KB)

References

[1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide

[2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[3]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2700 mL	11.3500 mL	22.6999 mL	56.7498 mL
	5 mM	0.4540 mL	2.2700 mL	4.5400 mL	11.3500 mL
	10 mM	0.2270 mL	1.1350 mL	2.2700 mL	5.6750 mL
	15 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	20 mM	0.1135 mL	0.5675 mL	1.1350 mL	2.8375 mL
	25 mM	0.0908 mL	0.4540 mL	0.9080 mL	2.2700 mL
	30 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8917 mL
	40 mM	0.0567 mL	0.2837 mL	0.5675 mL	1.4187 mL
	50 mM	0.0454 mL	0.2270 mL	0.4540 mL	1.1350 mL
	60 mM	0.0378 mL	0.1892 mL	0.3783 mL	0.9458 mL
	80 mM	0.0284 mL	0.1419 mL	0.2837 mL	0.7094 mL
	100 mM	0.0227 mL	0.1135 mL	0.2270 mL	0.5675 mL