2. Metabolic Enzyme/Protease Apoptosis
  3. Cathepsin Apoptosis
  4. TS-24

TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis.

For research use only. We do not sell to patients.

TS-24 Chemical Structure

TS-24 Chemical Structure

CAS No. : 1563260-97-8

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25 mg USD 590 In-stock
50 mg USD 950 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

TS-24 Related Antibodies

Top Publications Citing Use of Products

View All Cathepsin Isoform Specific Products:

View All Isoforms
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1].

IC50 & Target

cathepsin S

4.3 μM (IC50)

In Vitro

TS-24 (0-1 μM, 24 h) inhibits degradation of breast cancer susceptibility gene 1 (BRCA1) in cells HEK293T, and thus induces radiosensitization[1].
TS-24 (0-10 μM, 24 h) inhibits cell migration of MDA-MB-231[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TS-24 Related Antibodies

Cell Viability Assay[1]

Cell Line: MDA-MB-231
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Inhibited cell migration.

Western Blot Analysis[1]

Cell Line: MDA-MB-231
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Upregulated levels of BRCA1.
In Vivo

TS-24 (1 mg/kg, i.p., 3 times a week for 6 weeks) inhibits tumor growth in TNBC xenograft mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TNBC xenograft mice model>sup>[1]
Dosage: 1 mg/kg
Administration: i.p., 3 times a week for 6 weeks
Result: Inhibited tumor growth
Molecular Weight

301.34

Formula

C20H15NO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(/C=C/C1=CN(C)C2=C1C=CC=C2)C3=CC4=CC=CC=C4O3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 16.67 mg/mL (55.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3185 mL 16.5926 mL 33.1851 mL
5 mM 0.6637 mL 3.3185 mL 6.6370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3185 mL 16.5926 mL 33.1851 mL 82.9628 mL
5 mM 0.6637 mL 3.3185 mL 6.6370 mL 16.5926 mL
10 mM 0.3319 mL 1.6593 mL 3.3185 mL 8.2963 mL
15 mM 0.2212 mL 1.1062 mL 2.2123 mL 5.5309 mL
20 mM 0.1659 mL 0.8296 mL 1.6593 mL 4.1481 mL
25 mM 0.1327 mL 0.6637 mL 1.3274 mL 3.3185 mL
30 mM 0.1106 mL 0.5531 mL 1.1062 mL 2.7654 mL
40 mM 0.0830 mL 0.4148 mL 0.8296 mL 2.0741 mL
50 mM 0.0664 mL 0.3319 mL 0.6637 mL 1.6593 mL
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TS-24 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TS-241563260-97-8TS24TS 24CathepsinApoptosisTNBCtriple-negative breast cancerHEK293T,Inhibitorinhibitorinhibit

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