Tuberostemonine

Name: Tuberostemonine
Brand: MedChemExpress
SKU: HY-N0352
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0352 Purity: 99.71%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP⁺ reductases (pfFNR).

For research use only. We do not sell to patients.

Tuberostemonine Chemical Structure

CAS No. : 6879-01-2

Size	Price	Stock	Quantity
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Tuberostemonine:

Tuberostemonine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Tuberostemonine, an alkaloid, is an antimalarial agent that targets Plasmodium falciparum ferredoxin-NADP⁺ reductases (pfFNR)^[1].

Molecular Weight

375.50

Formula

C₂₂H₃₃NO₄

CAS No.

6879-01-2

Appearance

Solid

Color

White to off-white

SMILES

[H][C@@]([C@]1([H])[C@@]23[H])(CCCCN1[C@]([H])([C@@]4([H])OC([C@@H](C)C4)=O)C3)[C@@H](CC)[C@]([C@]2([H])[C@@H]5C)([H])OC5=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (133.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6631 mL	13.3156 mL	26.6312 mL
5 mM	0.5326 mL	2.6631 mL	5.3262 mL
10 mM	0.2663 mL	1.3316 mL	2.6631 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.71%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (258 KB) HNMR (292 KB) RP-HPLC (214 KB) MS (79 KB)

Handling Instructions (2659 KB)

References

[1]. Pudjiastuti P, et al. Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP⁺ Reductase from Malaria Parasites. J Parasitol Res. 2018 Aug 26;2018:3469132. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6631 mL	13.3156 mL	26.6312 mL	66.5779 mL
	5 mM	0.5326 mL	2.6631 mL	5.3262 mL	13.3156 mL
	10 mM	0.2663 mL	1.3316 mL	2.6631 mL	6.6578 mL
	15 mM	0.1775 mL	0.8877 mL	1.7754 mL	4.4385 mL
	20 mM	0.1332 mL	0.6658 mL	1.3316 mL	3.3289 mL
	25 mM	0.1065 mL	0.5326 mL	1.0652 mL	2.6631 mL
	30 mM	0.0888 mL	0.4439 mL	0.8877 mL	2.2193 mL
	40 mM	0.0666 mL	0.3329 mL	0.6658 mL	1.6644 mL
	50 mM	0.0533 mL	0.2663 mL	0.5326 mL	1.3316 mL
	60 mM	0.0444 mL	0.2219 mL	0.4439 mL	1.1096 mL
	80 mM	0.0333 mL	0.1664 mL	0.3329 mL	0.8322 mL
	100 mM	0.0266 mL	0.1332 mL	0.2663 mL	0.6658 mL