2. Anti-infection Protein Tyrosine Kinase/RTK TGF-beta/Smad Stem Cell/Wnt Epigenetics
  3. HIV Src PKA PKC
  4. TX-1918

TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM).

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TX-1918 Chemical Structure

TX-1918 Chemical Structure

CAS No. : 503473-32-3

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TX-1918 Related Antibodies

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HIV HIV-1 HIV-2

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Lck Fyn Blk

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PKA PKAR

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

TX-1918 is an inhibitor for eukaryotic elongation factor 2 kinase (eEF2-K) and Src kinase with IC50 of 0.44 and 4.4 μM, respectively. TX-1918 exhibits cytotoxicity in cell HepG2 and HCT116, with IC50 of 2.07 and 230 μM, respectively. TX-1918 inhibits the C-terminal domain of HIV-1 CA (CA CTD)(IC50 =3.81 μM), and inhibits the viral replication (IC50 =15.16 μM)[1][2].

IC50 & Target

IC50: 44 μM (PKA), 44 μM (PKC), 4.4 μM (Src), 0.44 μM (eEF2 kinase)
Molecular Weight

228.24

Formula

C14H12O3
CAS No.
SMILES

O=C1/C(C(C=C1)=O)=C\C2=CC(C)=C(O)C(C)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TX-1918 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TX-1918503473-32-3TX1918TX 1918HIVSrcPKAPKCHuman immunodeficiency virusProtein kinase AProtein kinase CHepG2HCT116Inhibitorinhibitorinhibit

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