2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. TZ3O

TZ3O (compound TZ30) is an anticholinergic agent with neuroprotective effects. TZ3O (2 mg/kg, 4 mg/kg) can improve memory impairment and cognitive decline in rats in the Scopolamine (HY-N0296)-induced Alzheimer-type model. TZ3O could be used in Alzheimer’s research.

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TZ3O Chemical Structure

TZ3O Chemical Structure

Size Price Stock Quantity
5 mg USD 483 In-stock
10 mg USD 692 In-stock
25 mg USD 1080 In-stock
50 mg USD 1490 In-stock
100 mg USD 1970 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TZ3O (compound TZ30) is an anticholinergic agent with neuroprotective effects. TZ3O (2 mg/kg, 4 mg/kg) can improve memory impairment and cognitive decline in rats in the Scopolamine (HY-N0296)-induced Alzheimer-type model. TZ3O could be used in Alzheimer’s research[1].

Molecular Weight

339.37

Formula

C18H13NO4S
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(S/C1=C/C2=CC=CC(O)=C2)N(C1=O)CC(C3=CC=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (368.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9466 mL 14.7332 mL 29.4664 mL
5 mM 0.5893 mL 2.9466 mL 5.8933 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9466 mL 14.7332 mL 29.4664 mL 73.6659 mL
5 mM 0.5893 mL 2.9466 mL 5.8933 mL 14.7332 mL
10 mM 0.2947 mL 1.4733 mL 2.9466 mL 7.3666 mL
15 mM 0.1964 mL 0.9822 mL 1.9644 mL 4.9111 mL
20 mM 0.1473 mL 0.7367 mL 1.4733 mL 3.6833 mL
25 mM 0.1179 mL 0.5893 mL 1.1787 mL 2.9466 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4555 mL
40 mM 0.0737 mL 0.3683 mL 0.7367 mL 1.8416 mL
50 mM 0.0589 mL 0.2947 mL 0.5893 mL 1.4733 mL
60 mM 0.0491 mL 0.2456 mL 0.4911 mL 1.2278 mL
80 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9208 mL
100 mM 0.0295 mL 0.1473 mL 0.2947 mL 0.7367 mL
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TZ3O Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TZ3OCholinesterase (ChE)Alzheimer’s diseaseThiazolidine-2,4-dioneacetylcholinesteraseanti-Alzheimer’s agentscholinergic pathwaydementiaInhibitorinhibitorinhibit

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