2. MAPK/ERK Pathway
  3. MEK
  4. U0124

U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM.

For research use only. We do not sell to patients.

U0124 Chemical Structure

U0124 Chemical Structure

CAS No. : 108923-79-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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Based on 1 publication(s) in Google Scholar

U0124 Related Antibodies

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MEK1 MEK2 MEK5 MEK

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Description

U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].

Molecular Weight

226.32

Formula

C8H10N4S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC(/C(C#N)=C(N)/SC)=C(N)\SC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (220.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4185 mL 22.0926 mL 44.1852 mL
5 mM 0.8837 mL 4.4185 mL 8.8370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4185 mL 22.0926 mL 44.1852 mL 110.4631 mL
5 mM 0.8837 mL 4.4185 mL 8.8370 mL 22.0926 mL
10 mM 0.4419 mL 2.2093 mL 4.4185 mL 11.0463 mL
15 mM 0.2946 mL 1.4728 mL 2.9457 mL 7.3642 mL
20 mM 0.2209 mL 1.1046 mL 2.2093 mL 5.5232 mL
25 mM 0.1767 mL 0.8837 mL 1.7674 mL 4.4185 mL
30 mM 0.1473 mL 0.7364 mL 1.4728 mL 3.6821 mL
40 mM 0.1105 mL 0.5523 mL 1.1046 mL 2.7616 mL
50 mM 0.0884 mL 0.4419 mL 0.8837 mL 2.2093 mL
60 mM 0.0736 mL 0.3682 mL 0.7364 mL 1.8411 mL
80 mM 0.0552 mL 0.2762 mL 0.5523 mL 1.3808 mL
100 mM 0.0442 mL 0.2209 mL 0.4419 mL 1.1046 mL
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U0124 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U0124108923-79-1U 0124U-0124MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInactive U0126 AnalogInhibitorinhibitorinhibit

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