Ubamatamab (Synonyms: REGN4018)

Cat. No.: HY-P99539 Purity: ≥99.0%: FAQs
Data Sheet SDS COA

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Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity.

For research use only. We do not sell to patients.

CAS No. : 2305629-50-7

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1 mg	In-stock	Estimated Time of Arrival: December 31
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Description

Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity^[1].

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species

Bispecific; Humanized

In Vitro

Ubamatamab (REGN4018; 0.1 pM-10 nM; 48 hours) induces human T cells and cynomolgus T cells to kill OVCAR-3 cells (EC50, 13.6 pM and 30.6 pM, respectively)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	OVCAR-3 cells
Concentration:	0.1 pM-10 nM
Incubation Time:	48 hours
Result:	Induced human T cells and cynomolgus T cells to kill OVCAR-3 cells.

In Vivo

Ubamatamab (REGN4018; 0.01-0.5 mg/kg; i.p; on days 6, 10, 13, 16, and 21) potently inhibits growth of intraperitoneal ovarian tumors^[1].
Ubamatamab (REGN4018; 0.01-1 mg/kg; i.p; once a week; total of five doses) shows minimal and transient increases in serum cytokines and C-reactive protein, with no overt toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells^[1]
Dosage:	0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
Administration:	i.p; on days 6, 10, 13, 16, and 21
Result:	Significantly reduced tumor burden, and did not result in any changes in weight.

Animal Model:	Cynomolgus monkeys
Dosage:	0.01, 0.1, or 1 mg/kg
Administration:	i.p; once a week; total of five doses
Result:	Showed minimal and transient increases in serum cytokines and C-reactive protein.

Clinical Trial

CAS No.

2305629-50-7

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ubamatamab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format

Human IgG4 kappa

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (259 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (568 KB) SEC-HPLC (756 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Alison Crawford, et al. A Mucin 16 bispecific T cell-engaging antibody for the treatment of ovarian cancer. Sci Transl Med. 2019 Jun 19;11(497):eaau7534. [Content Brief]

Ubamatamab Related Classifications

Inhibitory Antibodies

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ubamatamab2305629-50-7REGN4018REGN 4018REGN-4018CD3Cluster of differentiation 3MUC16antitumor activity,Inhibitorinhibitorinhibit

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