2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Ubretid

Ubretid  (Synonyms: Distigmine dibromide)

Cat. No.: HY-119577 Purity: ≥99.0%
COA Handling Instructions

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Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder.

For research use only. We do not sell to patients.

Ubretid Chemical Structure

Ubretid Chemical Structure

CAS No. : 15876-67-2

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1 mg USD 110 In-stock
5 mg USD 250 In-stock
10 mg USD 400 In-stock
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Based on 1 publication(s) in Google Scholar

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Ubretid Related Antibodies

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Description

Ubretid is a potent inhibitor of plasma cholinesterase. Ubretid therefore delays the hydrolysis of suxamethonium and prolongs its action, similar to the effects shown by other anticholinesterase agents, such as pyridostigmine and donepezil. Ubretid has the potential for the research of urinary retention prolongs the effect of suxamethonium. Ubretid is commonly prescribed for the research of myasthenia gravis and for difficulty in emptying the bladder[1].

Molecular Weight

576.32

Formula

C22H32Br2N4O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N(C)CCCCCCN(C)C(OC1=C[N+](C)=CC=C1)=O)OC2=C[N+](C)=CC=C2.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (173.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7351 mL 8.6757 mL 17.3515 mL
5 mM 0.3470 mL 1.7351 mL 3.4703 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7351 mL 8.6757 mL 17.3515 mL 43.3787 mL
5 mM 0.3470 mL 1.7351 mL 3.4703 mL 8.6757 mL
10 mM 0.1735 mL 0.8676 mL 1.7351 mL 4.3379 mL
15 mM 0.1157 mL 0.5784 mL 1.1568 mL 2.8919 mL
20 mM 0.0868 mL 0.4338 mL 0.8676 mL 2.1689 mL
25 mM 0.0694 mL 0.3470 mL 0.6941 mL 1.7351 mL
30 mM 0.0578 mL 0.2892 mL 0.5784 mL 1.4460 mL
40 mM 0.0434 mL 0.2169 mL 0.4338 mL 1.0845 mL
50 mM 0.0347 mL 0.1735 mL 0.3470 mL 0.8676 mL
60 mM 0.0289 mL 0.1446 mL 0.2892 mL 0.7230 mL
80 mM 0.0217 mL 0.1084 mL 0.2169 mL 0.5422 mL
100 mM 0.0174 mL 0.0868 mL 0.1735 mL 0.4338 mL
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Ubretid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ubretid15876-67-2Distigmine dibromideCholinesterase (ChE)plasma cholinesterasehydrolysissuxamethoniumanticholinesterasepyridostigminedonepezilmyasthenia gravisbladderInhibitorinhibitorinhibit

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