2. Apoptosis
  3. Apoptosis
  4. UR778Br

UR778Br targets the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML), arrests the cell cycle at the G2/M phase, and induces apoptosis. UR778Br inhibits colony formation of primary and AML cells, without significant impacts on normal bone marrow cells.

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UR778Br Chemical Structure

UR778Br Chemical Structure

CAS No. : 866127-80-2

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10 mg USD 150 In-stock
25 mg USD 300 In-stock
50 mg USD 480 In-stock
100 mg USD 780 In-stock
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Description

UR778Br targets the GTPase-activating protein-related domain (GRD domain) of IQGAP1 proteins. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML), arrests the cell cycle at the G2/M phase, and induces apoptosis. UR778Br inhibits colony formation of primary and AML cells, without significant impacts on normal bone marrow cells[1].

Molecular Weight

418.28

Formula

C20H20BrNO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCN1C(C(CC(C2=CC=CC=C2O)=O)(C3=C1C=CC(Br)=C3)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (34.16 mM; ultrasonic and warming and adjust pH to 3 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3907 mL 11.9537 mL 23.9074 mL
5 mM 0.4781 mL 2.3907 mL 4.7815 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3907 mL 11.9537 mL 23.9074 mL 59.7686 mL
5 mM 0.4781 mL 2.3907 mL 4.7815 mL 11.9537 mL
10 mM 0.2391 mL 1.1954 mL 2.3907 mL 5.9769 mL
15 mM 0.1594 mL 0.7969 mL 1.5938 mL 3.9846 mL
20 mM 0.1195 mL 0.5977 mL 1.1954 mL 2.9884 mL
25 mM 0.0956 mL 0.4781 mL 0.9563 mL 2.3907 mL
30 mM 0.0797 mL 0.3985 mL 0.7969 mL 1.9923 mL
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UR778Br Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UR778Br866127-80-2ApoptosisK562KG1αMOLM13MV411THP1U937leukemiaInhibitorinhibitorinhibit

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