2. Metabolic Enzyme/Protease GPCR/G Protein
  3. Endogenous Metabolite P2Y Receptor
  4. Uridine 5′-diphosphoglucose disodium salt

Uridine 5′-diphosphoglucose disodium salt  (Synonyms: UDP-D-Glucose disodium salt)

Cat. No.: HY-N7032 Purity: 99.83%
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Uridine 5’-diphosphoglucose (UDP-glucose) disodium salt, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium salt is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium salt is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue.

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Uridine 5′-diphosphoglucose disodium salt Chemical Structure

Uridine 5′-diphosphoglucose disodium salt Chemical Structure

CAS No. : 28053-08-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 35 In-stock
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100 mg USD 50 In-stock
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Based on 5 publication(s) in Google Scholar

Other Forms of Uridine 5′-diphosphoglucose disodium salt:

Uridine 5′-diphosphoglucose disodium salt Related Antibodies

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Description

Uridine 5’-diphosphoglucose (UDP-glucose) disodium salt, secreted by cardiomyocytes during ischemia and reperfu, is a potent agonist of the proinflammatory P2Y14 receptor. It acts an important role in the regulation of inflammation and neutrophil polarization in neutrophils. Uridine 5’-diphosphoglucose disodium salt is also the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine 5’-diphosphoglucose disodium salt is promising for research in counteracting myocardial infarction/reperfusion (MIR)-induced inflammation in the heart tissue[1][2][3][4].
IC50 & Target

Human Endogenous Metabolite

 

P2Y14 Receptor

 

Microbial Metabolite

 

In Vitro

Uridine 5’-diphosphoglucose disodium salt (0-100 μM, 24 h) upregulates the expression of P2Y14 receptor, which induces neutrophil apoptos[2].
Uridine 5’-diphosphoglucose (1 μM, 24 h) disodium salt and PPTN (HY-110322A) result in suppressed mRNA level of inflammatory factors including CCL3, IL1β,IL12a, TNF-α in neutrophils compared to cells treated with Uridine 5’-diphosphoglucose disodium salt alone, on the contrary, anti-inflammatory factors including IL10, TGF-β1, YM1 are upregulated upon Uridine 5’-diphosphoglucose disodium salt and PPTN (HY-110322A) in neutrophils[2].
Depletion of the pools of uridine 5’-diphosphoglucose disodium (5 or 20 mM, incubation for 3 h) salt in the liver of the rat was associated with decreased glycosylation of secreted and tissue glycoproteins, influencing the rate of glomerular basement membrane (GBM) synthesis in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uridine 5′-diphosphoglucose disodium salt Related Antibodies

Cell Viability Assay[2].

Cell Line: Neutrophils
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Decreased cell viability and elevated apoptosis of neutrophils, which was blunted by PPTN (HY-110322A).

Cell Migration Assay [2].

Cell Line: Neutrophils
Concentration: 1 μM
Incubation Time: 24 h
Result: Resulted in impaired neutrophil migration, which was inverted by PPTN (HY-110322A).
Molecular Weight

610.27

Formula

C15H22N2Na2O17P2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@](N2C(NC(C=C2)=O)=O)([H])O[C@@H]([C@H]1O)COP(OP(O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)(O[Na])=O)(O[Na])=O
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

H2O : ≥ 250 mg/mL (409.65 mM)

DMSO : 115 mg/mL (188.44 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6386 mL 8.1931 mL 16.3862 mL
5 mM 0.3277 mL 1.6386 mL 3.2772 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (8.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 0.55 mg/mL (0.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.55 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (163.86 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

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Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.83%

SDS (392 KB)

COA (250 KB) HNMR (291 KB) RP-HPLC (266 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 1.6386 mL 8.1931 mL 16.3862 mL 40.9655 mL
5 mM 0.3277 mL 1.6386 mL 3.2772 mL 8.1931 mL
10 mM 0.1639 mL 0.8193 mL 1.6386 mL 4.0965 mL
15 mM 0.1092 mL 0.5462 mL 1.0924 mL 2.7310 mL
20 mM 0.0819 mL 0.4097 mL 0.8193 mL 2.0483 mL
25 mM 0.0655 mL 0.3277 mL 0.6554 mL 1.6386 mL
30 mM 0.0546 mL 0.2731 mL 0.5462 mL 1.3655 mL
40 mM 0.0410 mL 0.2048 mL 0.4097 mL 1.0241 mL
50 mM 0.0328 mL 0.1639 mL 0.3277 mL 0.8193 mL
60 mM 0.0273 mL 0.1366 mL 0.2731 mL 0.6828 mL
80 mM 0.0205 mL 0.1024 mL 0.2048 mL 0.5121 mL
100 mM 0.0164 mL 0.0819 mL 0.1639 mL 0.4097 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Uridine 5′-diphosphoglucose disodium salt Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uridine 5′-diphosphoglucose disodium28053-08-9UDP-D-Glucose disodiumEndogenous MetaboliteP2Y ReceptorCardiomyocytesP2Y14 agonistInflammationNeutrophil polarizationNeutrophilsAnimal tissuesInhibitorinhibitorinhibit

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