2. GPCR/G Protein
  3. TSH Receptor
  4. VA-K-14 hydrochloride

VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).

For research use only. We do not sell to patients.

VA-K-14 hydrochloride Chemical Structure

VA-K-14 hydrochloride Chemical Structure

CAS No. : 1171341-19-7

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Based on 1 publication(s) in Google Scholar

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Description

VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM)[1].

Molecular Weight

341.86

Formula

C18H16ClN3S
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

CNC1=NC(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=CS1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (146.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9252 mL 14.6259 mL 29.2517 mL
5 mM 0.5850 mL 2.9252 mL 5.8503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.20%

SDS (252 KB)

COA (255 KB) HNMR (228 KB) RP-HPLC (265 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9252 mL 14.6259 mL 29.2517 mL 73.1294 mL
5 mM 0.5850 mL 2.9252 mL 5.8503 mL 14.6259 mL
10 mM 0.2925 mL 1.4626 mL 2.9252 mL 7.3129 mL
15 mM 0.1950 mL 0.9751 mL 1.9501 mL 4.8753 mL
20 mM 0.1463 mL 0.7313 mL 1.4626 mL 3.6565 mL
25 mM 0.1170 mL 0.5850 mL 1.1701 mL 2.9252 mL
30 mM 0.0975 mL 0.4875 mL 0.9751 mL 2.4376 mL
40 mM 0.0731 mL 0.3656 mL 0.7313 mL 1.8282 mL
50 mM 0.0585 mL 0.2925 mL 0.5850 mL 1.4626 mL
60 mM 0.0488 mL 0.2438 mL 0.4875 mL 1.2188 mL
80 mM 0.0366 mL 0.1828 mL 0.3656 mL 0.9141 mL
100 mM 0.0293 mL 0.1463 mL 0.2925 mL 0.7313 mL
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VA-K-14 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VA-K-141171341-19-7TSH ReceptorThyrotropin receptorThyroid-stimulating hormone Receptorpathological activationGraves' diseaseTSHR signalingnon-cytotoxicInhibitorinhibitorinhibit

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