Val-Ala-PABC-Exatecan

Cat. No.: HY-147095 Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Val-Ala-PABC-Exatecan is a Drug-Linker Conjugates for ADC，consiting of a cleavable Tesirine linker (Val-Ala-PABC) and Exatecan (topoisomerase I inhibitor，HY-13631). Val-Ala-PABC-Exatecan can be used for ADC molecues synthesis，such as Mal-PEGn-amide-va-Exatecan.

For research use only. We do not sell to patients.

Val-Ala-PABC-Exatecan Chemical Structure

CAS No. : 2845164-91-0

Size	Price	Stock	Quantity
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 960	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Val-Ala-PABC-Exatecan:

Val-Ala-PABC-Exatecan trifluoroacetate Get quote

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Camptothecins

Molecular Weight

754.80

Formula

C₄₀H₄₃FN₆O₈

CAS No.

2845164-91-0

Appearance

Solid

Color

Yellow to brown

SMILES

CC[C@]1(C(OCC2=C1C=C3C4=NC5=CC(F)=C(C6=C5C([C@H](CC6)NC(OCC7=CC=C(C=C7)NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)=O)=C4CN3C2=O)C)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (264.97 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3249 mL	6.6243 mL	13.2485 mL
5 mM	0.2650 mL	1.3249 mL	2.6497 mL
10 mM	0.1325 mL	0.6624 mL	1.3249 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (262 KB) HNMR (347 KB) RP-HPLC (206 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Cheng X, et al. MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FRα Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3249 mL	6.6243 mL	13.2485 mL	33.1214 mL
	5 mM	0.2650 mL	1.3249 mL	2.6497 mL	6.6243 mL
	10 mM	0.1325 mL	0.6624 mL	1.3249 mL	3.3121 mL
	15 mM	0.0883 mL	0.4416 mL	0.8832 mL	2.2081 mL
	20 mM	0.0662 mL	0.3312 mL	0.6624 mL	1.6561 mL
	25 mM	0.0530 mL	0.2650 mL	0.5299 mL	1.3249 mL
	30 mM	0.0442 mL	0.2208 mL	0.4416 mL	1.1040 mL
	40 mM	0.0331 mL	0.1656 mL	0.3312 mL	0.8280 mL
	50 mM	0.0265 mL	0.1325 mL	0.2650 mL	0.6624 mL
	60 mM	0.0221 mL	0.1104 mL	0.2208 mL	0.5520 mL
	80 mM	0.0166 mL	0.0828 mL	0.1656 mL	0.4140 mL
	100 mM	0.0132 mL	0.0662 mL	0.1325 mL	0.3312 mL