2. PROTAC
  3. Ligands for E3 Ligase
  4. VH 101, acid

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand.

For research use only. We do not sell to patients.

VH 101, acid Chemical Structure

VH 101, acid Chemical Structure

CAS No. : 2408341-97-7

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Based on 1 publication(s) in Google Scholar

VH 101, acid Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

VH 101, acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development. VH 101, acid contains an E3 ligase ligand plus an alkyl linker with terminal amine ready for conjugation to a target protein ligand[1].

IC50 & Target

VHL

 

Molecular Weight

574.66

Formula

C28H35FN4O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(CC1)F)N[C@@H](C(C)(C)C)C(N2[C@@H](C[C@H](C2)O)C(N[C@H](C3=CC=C(C4=C(N=CS4)C)C=C3)CC(O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (174.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7402 mL 8.7008 mL 17.4016 mL
5 mM 0.3480 mL 1.7402 mL 3.4803 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7402 mL 8.7008 mL 17.4016 mL 43.5040 mL
5 mM 0.3480 mL 1.7402 mL 3.4803 mL 8.7008 mL
10 mM 0.1740 mL 0.8701 mL 1.7402 mL 4.3504 mL
15 mM 0.1160 mL 0.5801 mL 1.1601 mL 2.9003 mL
20 mM 0.0870 mL 0.4350 mL 0.8701 mL 2.1752 mL
25 mM 0.0696 mL 0.3480 mL 0.6961 mL 1.7402 mL
30 mM 0.0580 mL 0.2900 mL 0.5801 mL 1.4501 mL
40 mM 0.0435 mL 0.2175 mL 0.4350 mL 1.0876 mL
50 mM 0.0348 mL 0.1740 mL 0.3480 mL 0.8701 mL
60 mM 0.0290 mL 0.1450 mL 0.2900 mL 0.7251 mL
80 mM 0.0218 mL 0.1088 mL 0.2175 mL 0.5438 mL
100 mM 0.0174 mL 0.0870 mL 0.1740 mL 0.4350 mL
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VH 101, acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VH 101, acid2408341-97-7Ligands for E3 LigaseE3 ligase-recruiting MoietyVHLPROTACE3Inhibitorinhibitorinhibit

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