2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. Vimnerixin

Vimnerixin  (Synonyms: AZD4721; RIST4721)

Cat. No.: HY-145640 Purity: 99.39%
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Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease.

For research use only. We do not sell to patients.

Vimnerixin Chemical Structure

Vimnerixin Chemical Structure

CAS No. : 1418112-77-2

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5 mg USD 780 In-stock
10 mg USD 1250 In-stock
25 mg USD 2580 In-stock
50 mg USD 4000 In-stock
100 mg USD 6400 In-stock
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Based on 1 publication(s) in Google Scholar

Vimnerixin Related Antibodies

Top Publications Citing Use of Products

View All CXCR Isoform Specific Products:

View All Isoforms
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Vimnerixin (AZD4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). Vimnerixin has the potential for the research of inflammatory disease[1].

IC50 & Target

CXCR2[1]
In Vivo

Assessment of Pharmacokinetics (PK) profile of Vimnerixin in rat and dog[1]
.

In Vivo PK Rat Dog
Predicted hepatic metabolic CL (ml/min per kilogram) 1.7 0.80
Observed CL (ml/min per kilogram) 2.4 0.50
CLrenal (mL/min per kilogram) <0.01 <0.01
CLbiliary (mL/min per kilogram) <0.01 0.04
In vivo/in vitro unbound CLintc 1.4 0.6
VSS (l/kg) 0.19 0.15
T1/2 (h) (PO) 1.3 3.7
(2.7) (8.4)
F (%) 45 82

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

472.55

Formula

C19H25FN4O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=NC(SCC2=CC=C(C=C2)F)=NC(O[C@H](C)[C@@H](O)CO)=C1)(N3CC(C3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (211.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1162 mL 10.5809 mL 21.1618 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1162 mL 10.5809 mL 21.1618 mL 52.9045 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL 10.5809 mL
10 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2904 mL
15 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5270 mL
20 mM 0.1058 mL 0.5290 mL 1.0581 mL 2.6452 mL
25 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1162 mL
30 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
40 mM 0.0529 mL 0.2645 mL 0.5290 mL 1.3226 mL
50 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
60 mM 0.0353 mL 0.1763 mL 0.3527 mL 0.8817 mL
80 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
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Vimnerixin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vimnerixin1418112-77-2AZD4721 RIST4721AZD 4721AZD-4721RIST4721RIST 4721RIST-4721CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsCXCR2acidic CXC chemokine receptor 2inflammatory diseaseInhibitorinhibitorinhibit

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