2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Violacein

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer.

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Violacein Chemical Structure

Violacein Chemical Structure

CAS No. : 548-54-9

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Based on 1 publication(s) in Google Scholar

Violacein Related Antibodies

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Description

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

IC50 & Target

Microbial Metabolite

 

Cellular Effect
Cell Line Type Value Description References
Caco-2 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) Caco2 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
DLD-1 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) DLD1 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HCT-116 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HCT116 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
HT-29 IC50
> 1.5 μM
Compound: violacein
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
Cytotoxicity against Homo sapiens (human) HT-29 cells after 24 to 48 hr by MTT assay
10.1007/s00044-011-9654-9
In Vitro

Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1].
Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Violacein Related Antibodies

Cell Viability Assay[1].

Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells.
Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM.
Incubation Time: 24h.
Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).
Molecular Weight

343.34

Formula

C20H13N3O3
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C1/C(C2=CC=CC=C2N1)=C3C=C(C(C4=C5)=CNC4=CC=C5O)NC\3=O
Structure Classification
Initial Source

Chromobacterium violaceum
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Violacein Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Violacein548-54-9ApoptosisEndogenous MetaboliteAnticancerMicroorganisms Secondary Metaboliteantioxidantapoptosiscolon cancer,Inhibitorinhibitorinhibit

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