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  4. VPC-18005

VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity.

For research use only. We do not sell to patients.

VPC-18005 Chemical Structure

VPC-18005 Chemical Structure

CAS No. : 2242480-48-2

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5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2100 In-stock
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Based on 1 publication(s) in Google Scholar

VPC-18005 Related Antibodies

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Description

VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1].
In Vitro

VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1].
VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1].
VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1].
VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1].
The exposure of larvae to 1 or 10 µM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-18005 Related Antibodies

Cell Viability Assay[1]

Cell Line: PNT1B-Mock cells and PNT1B-ERG cells.
Concentration: 5 µM.
Incubation Time: 24 h.
Result: Inhibited migration and invasion of prostate cell lines in vitro.
Molecular Weight

319.38

Formula

C15H17N3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(S/C(N1)=N\N=C/C2=CC=C(C(C)C)C=C2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (195.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1311 mL 15.6553 mL 31.3107 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1311 mL 15.6553 mL 31.3107 mL 78.2767 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL 15.6553 mL
10 mM 0.3131 mL 1.5655 mL 3.1311 mL 7.8277 mL
15 mM 0.2087 mL 1.0437 mL 2.0874 mL 5.2184 mL
20 mM 0.1566 mL 0.7828 mL 1.5655 mL 3.9138 mL
25 mM 0.1252 mL 0.6262 mL 1.2524 mL 3.1311 mL
30 mM 0.1044 mL 0.5218 mL 1.0437 mL 2.6092 mL
40 mM 0.0783 mL 0.3914 mL 0.7828 mL 1.9569 mL
50 mM 0.0626 mL 0.3131 mL 0.6262 mL 1.5655 mL
60 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3046 mL
80 mM 0.0391 mL 0.1957 mL 0.3914 mL 0.9785 mL
100 mM 0.0313 mL 0.1566 mL 0.3131 mL 0.7828 mL
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VPC-18005 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-180052242480-48-2VPC18005VPC 18005OthersprostatecancerETSERGPNT1BInhibitorinhibitorinhibit

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