2. Anti-infection
  3. Fungal
  4. VT-1598

VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris. VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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VT-1598 Chemical Structure

VT-1598 Chemical Structure

CAS No. : 2089320-99-8

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Based on 1 publication(s) in Google Scholar

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VT-1598 Related Antibodies

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Description

VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris[1][2]. VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

VT-1598 (0.015-8 μg/mL; 24 h) demonstrates in vitro activity against C. auris[1].
VT-1598 (0.03125-0.125 μg/mL; 24 h) shows highly effects in inhibiting the in vitro growth of clinical Candida isolates[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VT-1598 Related Antibodies

Cell Viability Assay[1]

Cell Line: 100 C. auris isolates
Concentration: 0.015-8 μg/mL
Incubation Time: 24 hours
Result: Showed MICs ranging from 0.03 to 8 μg/ mL against all isolates, with MIC50 and MIC90 values of 0.25 and 1 μg/mL, respectively.

Cell Viability Assay[2]

Cell Line: 28 Candida isolates obtained from mucosal sites of APECED patients
Concentration: 0.03125-0.125 μg/mL
Incubation Time: 24 hours
Result: Demonstrated potent in vitro activity against all 28 isolates (MIC range=0.03125-0.125 mg/L), with the MIC50 and MIC90 values of 0.0625 and 0.125 mg/L, respectively.
In Vivo

VT-1598 (oral gavage; 5, 15, and 50 mg/kg; once daily; 7 d) treatment shows a significant and dose-dependent survival advantage, and dose-dependent reductions in fungal burden[1].
VT-1598 (oral gavage; 3.2, 8, and 20 mg/kg; once daily; 4 d) is present to a great extent in the plasma and tongue after oral administration in Act1-deficient mice infected with C. albicans[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice model of invasive candidiasis[1]
Dosage: 5, 15, and 50 mg/kg
Administration: Oral gavage; once daily; 7 days
Result: Observed median survival in the VT-1598 15 mg/kg and 50 mg/kg groups (15 days and >21 days, respectively) longer than the control group.
Observed kidney fungal burden in mice treated with 15 mg/kg and 50 mg/kg doses (mean log10 CFU/g, 5.40 and 3.67, respectively) lower than the vehicle control group.
Showed mean trough concentrations 1.55 μg/mL after 7 days of therapy in the 5 mg/kg group, 6.78 μg/mL in the 15 mg/kg group, and 14.2 μg/mL in the 50 mg/kg group.
Animal Model: Act1-deficient mice infected with C. albicans[2]
Dosage: 3.2, 8, and 20 mg/kg
Administration: Oral gavage; once daily; 4 days
Result: Resulted in high concentrations in the plasma and tongues of Candida-infected mice.
Clinical Trial
Molecular Weight

584.52

Formula

C31H20F4N6O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1=CC=C(COC2=CC=C(C#CC3=CC=C(C(F)(F)[C@@](O)(C4=CC=C(F)C=C4F)CN5N=NN=C5)N=C3)C=C2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (171.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7108 mL 8.5540 mL 17.1081 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7108 mL 8.5540 mL 17.1081 mL 42.7701 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL 8.5540 mL
10 mM 0.1711 mL 0.8554 mL 1.7108 mL 4.2770 mL
15 mM 0.1141 mL 0.5703 mL 1.1405 mL 2.8513 mL
20 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1385 mL
25 mM 0.0684 mL 0.3422 mL 0.6843 mL 1.7108 mL
30 mM 0.0570 mL 0.2851 mL 0.5703 mL 1.4257 mL
40 mM 0.0428 mL 0.2139 mL 0.4277 mL 1.0693 mL
50 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
60 mM 0.0285 mL 0.1426 mL 0.2851 mL 0.7128 mL
80 mM 0.0214 mL 0.1069 mL 0.2139 mL 0.5346 mL
100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4277 mL
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VT-1598 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VT-15982089320-99-8VT1598VT 1598Fungaloral activityanti-fungal activityC. auris isolatesCandida isolatesInhibitorinhibitorinhibit

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