W-13 hydrochloride

Cat. No.: HY-100910 Purity: 99.86%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A)-resistant human breast cancer cell growth.

For research use only. We do not sell to patients.

W-13 hydrochloride Chemical Structure

CAS No. : 88519-57-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A)-resistant human breast cancer cell growth^[1].

Molecular Weight

349.28

Formula

C₁₄H₁₈Cl₂N₂O₂S

CAS No.

88519-57-7

Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C2C(Cl)=CC=CC2=C1)(NCCCCN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (357.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8630 mL	14.3152 mL	28.6303 mL
5 mM	0.5726 mL	2.8630 mL	5.7261 mL
10 mM	0.2863 mL	1.4315 mL	2.8630 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.86%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (262 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Tallant EA, et, al. Calmodulin antagonists elevate the levels of 32P-labeled polyphosphoinositides in human platelets. Biochem Biophys Res Commun. 1985 Aug 30;131(1):370-7. [Content Brief]

[2]. Strobl JS, et, al. Tamoxifen-resistant human breast cancer cell growth: inhibition by thioridazine, pimozide and the calmodulin antagonist, W-13. J Pharmacol Exp Ther. 1992 Oct;263(1):186-93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8630 mL	14.3152 mL	28.6303 mL	71.5758 mL
	5 mM	0.5726 mL	2.8630 mL	5.7261 mL	14.3152 mL
	10 mM	0.2863 mL	1.4315 mL	2.8630 mL	7.1576 mL
	15 mM	0.1909 mL	0.9543 mL	1.9087 mL	4.7717 mL
	20 mM	0.1432 mL	0.7158 mL	1.4315 mL	3.5788 mL
	25 mM	0.1145 mL	0.5726 mL	1.1452 mL	2.8630 mL
	30 mM	0.0954 mL	0.4772 mL	0.9543 mL	2.3859 mL
	40 mM	0.0716 mL	0.3579 mL	0.7158 mL	1.7894 mL
	50 mM	0.0573 mL	0.2863 mL	0.5726 mL	1.4315 mL
	60 mM	0.0477 mL	0.2386 mL	0.4772 mL	1.1929 mL
	80 mM	0.0358 mL	0.1789 mL	0.3579 mL	0.8947 mL
	100 mM	0.0286 mL	0.1432 mL	0.2863 mL	0.7158 mL