2. Membrane Transporter/Ion Channel
  3. URAT1
  4. Xininurad

Xininurad (XNW3009) is a urate transporter (URAT) inhibitor

For research use only. We do not sell to patients.

Xininurad Chemical Structure

Xininurad Chemical Structure

CAS No. : 2365178-28-3

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Based on 1 publication(s) in Google Scholar

Xininurad Related Antibodies

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Description

Xininurad (XNW3009) is a urate transporter (URAT) inhibitor[1]

IC50 & Target

URAT[1]
Clinical Trial
Molecular Weight

443.07

Formula

C15H10Br2FN3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=C(CC)N=C2N=CC(F)=CN21)C3=CC(Br)=C(C(Br)=C3)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (112.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2570 mL 11.2849 mL 22.5698 mL
5 mM 0.4514 mL 2.2570 mL 4.5140 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2570 mL 11.2849 mL 22.5698 mL 56.4245 mL
5 mM 0.4514 mL 2.2570 mL 4.5140 mL 11.2849 mL
10 mM 0.2257 mL 1.1285 mL 2.2570 mL 5.6424 mL
15 mM 0.1505 mL 0.7523 mL 1.5047 mL 3.7616 mL
20 mM 0.1128 mL 0.5642 mL 1.1285 mL 2.8212 mL
25 mM 0.0903 mL 0.4514 mL 0.9028 mL 2.2570 mL
30 mM 0.0752 mL 0.3762 mL 0.7523 mL 1.8808 mL
40 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.4106 mL
50 mM 0.0451 mL 0.2257 mL 0.4514 mL 1.1285 mL
60 mM 0.0376 mL 0.1881 mL 0.3762 mL 0.9404 mL
80 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
100 mM 0.0226 mL 0.1128 mL 0.2257 mL 0.5642 mL
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Xininurad Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xininurad2365178-28-3XNW3009XNW 3009XNW-3009URAT1Urate transporter 1SLC22A12urateInhibitorinhibitorinhibit

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