Yadanzigan  (Synonyms: YDZG)

Yadanzigan (YDZG) is an anti-inflammatory agent and a NLRP3 inhibitor. Yadanzigan specifically inhibits NLRP3 activation via inhibiting NF-κB pathway and Reactive Oxygen Species production. Yadanzigan also moderates LPS (HY-D1056)-induced acute lung injury (ALI) in mice^[1].

Yadanzigan (20, 40, and 80 μM; 1 h) promotes Nrf2 translocation from the cytoplasm into the nucleus in RAW264.7 macrophages^[1].
Yadanzigan (20 μM; 1 h) suppresses mitochondrial reactive oxygen species (ROS) generation in HEK293T cells induced by LPS (1 μg/mL; 6 h)^[1].
Yadanzigan (40 μM; 1 h) significantly blocks the formation of the NLRP3 inflammasome in J774A.1 cells induce by LPS and ATP^[1].
Yadanzigan (2.5-10 μM or 10-40 μM; 1, 6, 12 h) enhances TRIM31 expression to promote NLRP3 protein degradation in J774A.1, and THP-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yadanzigan (5 mg/kg, 10 mg/kg; i.v.; dose for 3 times) prevents LPS-induced acute lung injury in mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

574.57

C₂₆H₃₈O₁₄

76588-87-9

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• [1]. Cui Y, et al. Yadanzigan, a quassinoid glucoside, attenuates NLRP3 inflammasome activation to prevent LPS-induced acute lung injury. Authorea Preprints, 2020.