Z-Ala-Arg-Arg-AMC (Synonyms: Fluorogenic Proteasome Substrate; Z-ARR-AMC)

Cat. No.: HY-134961 Purity: 98.00%: FAQs
Data Sheet SDS COA Handling Instructions

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Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-Ala-Arg-Arg-AMC Chemical Structure

CAS No. : 90468-18-1

Size	Price	Stock	Quantity
5 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome^[1].

Molecular Weight

692.77

Formula

C₃₃H₄₄N₁₀O₇

CAS No.

90468-18-1

Appearance

Solid

Color

White to off-white

Sequence

Z-Ala-Arg-Arg-AMC

Sequence Shortening

Z-ARR-AMC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (72.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4435 mL	7.2174 mL	14.4348 mL
5 mM	0.2887 mL	1.4435 mL	2.8870 mL
10 mM	0.1443 mL	0.7217 mL	1.4435 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.00%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (249 KB) RP-HPLC (228 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Crawford LJ, et al. Comparative selectivity and specificity of the proteasome inhibitors BzLLLCOCHO, PS-341, and MG-132. Cancer Res. 2006 Jun 15;66(12):6379-86. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4435 mL	7.2174 mL	14.4348 mL	36.0870 mL
	5 mM	0.2887 mL	1.4435 mL	2.8870 mL	7.2174 mL
	10 mM	0.1443 mL	0.7217 mL	1.4435 mL	3.6087 mL
	15 mM	0.0962 mL	0.4812 mL	0.9623 mL	2.4058 mL
	20 mM	0.0722 mL	0.3609 mL	0.7217 mL	1.8044 mL
	25 mM	0.0577 mL	0.2887 mL	0.5774 mL	1.4435 mL
	30 mM	0.0481 mL	0.2406 mL	0.4812 mL	1.2029 mL
	40 mM	0.0361 mL	0.1804 mL	0.3609 mL	0.9022 mL
	50 mM	0.0289 mL	0.1443 mL	0.2887 mL	0.7217 mL
	60 mM	0.0241 mL	0.1203 mL	0.2406 mL	0.6015 mL

Z-Ala-Arg-Arg-AMC Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Ala-Arg-Arg-AMC90468-18-1Fluorogenic Proteasome Substrate Z-ARR-AMCProteasometrypsin-likeproteasomeInhibitorinhibitorinhibit

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