2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Z-FF-FMK

Z-FF-FMK  (Synonyms: Z-Phe-Phe-FMK)

Cat. No.: HY-141867 Purity: 98.71%
SDS COA Handling Instructions

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Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-FF-FMK Chemical Structure

Z-FF-FMK Chemical Structure

CAS No. : 105608-85-3

Size Price Stock Quantity
5 mg USD 200 In-stock
10 mg USD 320 In-stock
25 mg USD 640 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Other Forms of Z-FF-FMK:

Z-FF-FMK Related Antibodies

Top Publications Citing Use of Products

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • Biological Activity

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Description

Z-FF-FMK is a selective cathepsin-L inhibitor. Z-FF-FMK can prevent β-amyloid to induce apoptotic changes such as activation of caspase-3, cleavage of the DNA repair enzyme, poly-ADP ribose polymerase, and DNA fragmentation[1].

Molecular Weight

462.51

Formula

C27H27FN2O4
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Z-Phe-Phe-FMK
Sequence Shortening

Z-FF-FMK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1621 mL 10.8106 mL 21.6212 mL
5 mM 0.4324 mL 2.1621 mL 4.3242 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.71%

SDS (252 KB)

COA (250 KB) RP-HPLC (111 KB) MS (220 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1621 mL 10.8106 mL 21.6212 mL 54.0529 mL
5 mM 0.4324 mL 2.1621 mL 4.3242 mL 10.8106 mL
10 mM 0.2162 mL 1.0811 mL 2.1621 mL 5.4053 mL
15 mM 0.1441 mL 0.7207 mL 1.4414 mL 3.6035 mL
20 mM 0.1081 mL 0.5405 mL 1.0811 mL 2.7026 mL
25 mM 0.0865 mL 0.4324 mL 0.8648 mL 2.1621 mL
30 mM 0.0721 mL 0.3604 mL 0.7207 mL 1.8018 mL
40 mM 0.0541 mL 0.2703 mL 0.5405 mL 1.3513 mL
50 mM 0.0432 mL 0.2162 mL 0.4324 mL 1.0811 mL
60 mM 0.0360 mL 0.1802 mL 0.3604 mL 0.9009 mL
80 mM 0.0270 mL 0.1351 mL 0.2703 mL 0.6757 mL
100 mM 0.0216 mL 0.1081 mL 0.2162 mL 0.5405 mL
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Z-FF-FMK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-FF-FMK105608-85-3Z-Phe-Phe-FMKCathepsinβ-amyloidapoptoticcaspase-3DNA repair enzymepoly-ADP ribose polymeraseDNA fragmentationInhibitorinhibitorinhibit

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