2. Metabolic Enzyme/Protease Anti-infection
  3. Cathepsin SARS-CoV
  4. Z-Phe-Tyr(tBu)-diazomethylketone

Z-Phe-Tyr(tBu)-diazomethylketone 

Cat. No.: HY-138208 Purity: 98.04%
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Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection.

For research use only. We do not sell to patients.

Z-Phe-Tyr(tBu)-diazomethylketone Chemical Structure

Z-Phe-Tyr(tBu)-diazomethylketone Chemical Structure

CAS No. : 114014-15-2

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1 mg USD 40 In-stock
5 mg USD 140 In-stock
10 mg USD 230 In-stock
25 mg USD 460 In-stock
50 mg USD 730 In-stock
100 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

Z-Phe-Tyr(tBu)-diazomethylketone Related Antibodies

Top Publications Citing Use of Products

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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  • Purity & Documentation

  • References

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Description

Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection[1][2].

IC50 & Target[1]

cathepsin L

 

In Vitro

Z-Phe-Tyr(tBu)-diazomethylketone (3.3, 10 µM; 3 h) resultes in reovirus inefficient proteolytic disassembly of viral outer-capsid proteins and decreases viral yields in L929 cells[1].
Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection to about 10% of vehicle-treated controls in SARS-CoV-2 infection of cardiomyocytes (CMs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z-Phe-Tyr(tBu)-diazomethylketone Related Antibodies
Molecular Weight

542.63

Formula

C31H34N4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H](C(C=[N+]=[N-])=O)CC(C=C1)=CC=C1OC(C)(C)C)[C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (460.72 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8429 mL 9.2144 mL 18.4288 mL
5 mM 0.3686 mL 1.8429 mL 3.6858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8429 mL 9.2144 mL 18.4288 mL 46.0719 mL
5 mM 0.3686 mL 1.8429 mL 3.6858 mL 9.2144 mL
10 mM 0.1843 mL 0.9214 mL 1.8429 mL 4.6072 mL
15 mM 0.1229 mL 0.6143 mL 1.2286 mL 3.0715 mL
20 mM 0.0921 mL 0.4607 mL 0.9214 mL 2.3036 mL
25 mM 0.0737 mL 0.3686 mL 0.7372 mL 1.8429 mL
30 mM 0.0614 mL 0.3071 mL 0.6143 mL 1.5357 mL
40 mM 0.0461 mL 0.2304 mL 0.4607 mL 1.1518 mL
50 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.9214 mL
60 mM 0.0307 mL 0.1536 mL 0.3071 mL 0.7679 mL
80 mM 0.0230 mL 0.1152 mL 0.2304 mL 0.5759 mL
100 mM 0.0184 mL 0.0921 mL 0.1843 mL 0.4607 mL
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Z-Phe-Tyr(tBu)-diazomethylketone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Phe-Tyr(tBu)-diazomethylketone114014-15-2CathepsinSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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