2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Zasocitinib

Zasocitinib  (Synonyms: NDI-034858; TAK-279)

Cat. No.: HY-150096 Purity: 98.98%
COA Handling Instructions

Molarity Calculator

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM.

For research use only. We do not sell to patients.

Zasocitinib Chemical Structure

Zasocitinib Chemical Structure

CAS No. : 2272904-53-5

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1 mg USD 320 In-stock
5 mg USD 950 In-stock
10 mg USD 1520 In-stock
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Based on 1 publication(s) in Google Scholar

Zasocitinib Related Antibodies

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Zasocitinib (NDI-034858) is a TYK2 inhibitor, target TYK2 JH2 domain with binding constant Kd of <200 pM[1].

IC50 & Target

Tyk2 JH2 domain[1]
In Vitro

Zasocitinib (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1].
Zasocitinib inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50 value of <0.1 μM in human peripheral blood mononuclear cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zasocitinib Related Antibodies
Clinical Trial
Molecular Weight

460.49

Formula

C23H24N8O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CO[C@H](CC1)[C@@H]1NC(C2=C3N(N=C2)C(NC)=CC(NC4=CC=CN(C5=CC=CC=N5)C4=O)=N3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (108.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1716 mL 10.8580 mL 21.7160 mL
5 mM 0.4343 mL 2.1716 mL 4.3432 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.98%

COA (250 KB) HNMR (169 KB) RP-HPLC (247 KB) LCMS (282 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1716 mL 10.8580 mL 21.7160 mL 54.2900 mL
5 mM 0.4343 mL 2.1716 mL 4.3432 mL 10.8580 mL
10 mM 0.2172 mL 1.0858 mL 2.1716 mL 5.4290 mL
15 mM 0.1448 mL 0.7239 mL 1.4477 mL 3.6193 mL
20 mM 0.1086 mL 0.5429 mL 1.0858 mL 2.7145 mL
25 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1716 mL
30 mM 0.0724 mL 0.3619 mL 0.7239 mL 1.8097 mL
40 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
50 mM 0.0434 mL 0.2172 mL 0.4343 mL 1.0858 mL
60 mM 0.0362 mL 0.1810 mL 0.3619 mL 0.9048 mL
80 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6786 mL
100 mM 0.0217 mL 0.1086 mL 0.2172 mL 0.5429 mL
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Zasocitinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zasocitinib2272904-53-5NDI-034858 TAK-279NDI034858NDI 034858TAK279TAK 279TAK-279JAKJanus kinaseheterodimer complexphosphorylation inductionIL-12JH1 domainhuman peripheral blood mononuclear cellPBMCInhibitorinhibitorinhibit

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