2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. α2A-AR agonist 1

α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes.

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α2A-AR agonist 1 Chemical Structure

α2A-AR agonist 1 Chemical Structure

CAS No. : 2971825-58-6

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α2A-AR agonist 1 Related Antibodies

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Description

α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes[1].

IC50 & Target

Alpha-2A adrenergic receptor

0.23 nM (EC50)

Alpha-1A adrenergic receptor

2.5 nM (EC50)

Alpha-2B adrenergic receptor

16.3 nM (EC50)

Alpha-2C adrenergic receptor

21.3 nM (EC50)

Molecular Weight

279.13

Formula

C12H11BrN2O
CAS No.
SMILES

BrC1=C(C2=CC=C1)OCCC2C3=CNC=N3
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Purity & Documentation
References
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α2A-AR agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α2A-AR agonist 12971825-58-6Adrenergic ReceptorBeta ReceptorselectiveLORRC57BL/6 mouseInhibitorinhibitorinhibit

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