α2A-AR agonist 1

Cat. No.: HY-162620 Purity: 99.92%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC₅₀ of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED₅₀ of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes.

For research use only. We do not sell to patients.

α2A-AR agonist 1 Chemical Structure

CAS No. : 2971825-58-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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α adrenergic receptor β adrenergic receptor

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Description

IC₅₀ & Target

Alpha-2A adrenergic receptor

0.23 nM (EC₅₀)

Alpha-1A adrenergic receptor

2.5 nM (EC₅₀)

Alpha-2B adrenergic receptor

16.3 nM (EC₅₀)

Alpha-2C adrenergic receptor

21.3 nM (EC₅₀)

Molecular Weight

279.13

Formula

C₁₂H₁₁BrN₂O

CAS No.

2971825-58-6

Appearance

Solid

Color

White to off-white

SMILES

BrC1=C(C2=CC=C1)OCCC2C3=CNC=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 87.5 mg/mL (313.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5826 mL	17.9128 mL	35.8256 mL
5 mM	0.7165 mL	3.5826 mL	7.1651 mL
10 mM	0.3583 mL	1.7913 mL	3.5826 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (251 KB) HNMR (247 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Lv X, et al., Designing Chromane Derivatives as α2A-Adrenoceptor Selective Agonists via Conformation Constraint. J Med Chem. 2024 Jun 18. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5826 mL	17.9128 mL	35.8256 mL	89.5640 mL
	5 mM	0.7165 mL	3.5826 mL	7.1651 mL	17.9128 mL
	10 mM	0.3583 mL	1.7913 mL	3.5826 mL	8.9564 mL
	15 mM	0.2388 mL	1.1942 mL	2.3884 mL	5.9709 mL
	20 mM	0.1791 mL	0.8956 mL	1.7913 mL	4.4782 mL
	25 mM	0.1433 mL	0.7165 mL	1.4330 mL	3.5826 mL
	30 mM	0.1194 mL	0.5971 mL	1.1942 mL	2.9855 mL
	40 mM	0.0896 mL	0.4478 mL	0.8956 mL	2.2391 mL
	50 mM	0.0717 mL	0.3583 mL	0.7165 mL	1.7913 mL
	60 mM	0.0597 mL	0.2985 mL	0.5971 mL	1.4927 mL
	80 mM	0.0448 mL	0.2239 mL	0.4478 mL	1.1196 mL
	100 mM	0.0358 mL	0.1791 mL	0.3583 mL	0.8956 mL

α2A-AR agonist 1 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α2A-AR agonist 12971825-58-6Adrenergic ReceptorBeta ReceptorselectiveLORRC57BL/6 mouseInhibitorinhibitorinhibit

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α2A-AR agonist 1

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α2A-AR agonist 1 Related Antibodies

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References

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

α2A-AR agonist 1 Related Classifications

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