β-Sitostenone (Synonyms: Δ4-Sitosterol-3-one; β-Rosasterol oxide)

Cat. No.: HY-N1238 Purity: ≥95.0%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities.

For research use only. We do not sell to patients.

β-Sitostenone Chemical Structure

CAS No. : 1058-61-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

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Description

β-Sitostenone is a sterols that can be isolated from Cochlospermum vitifolium.β-Sitostenone inhibits tyrosinase activity, and has anti-melanogenic and anti-tumor activities^[1]^[2]^[3].

IC₅₀ & Target

Human Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
COLO 205	IC₅₀	> 10 μM Compound: 3	Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay Cytotoxicity against human COLO205 cells after 24 hrs by MTT assay	[PMID: 30199257]
COLO 320	IC₅₀	> 10 μM Compound: 3	Cytotoxicity against human COLO320 cells after 24 hrs by MTT assay Cytotoxicity against human COLO320 cells after 24 hrs by MTT assay	[PMID: 30199257]
L5178Y	IC₅₀	> 10 μM Compound: 3	Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay Antiproliferative activity against mouse L5178Y cells after 72 hrs by MTT assay	[PMID: 30199257]
L5178Y	IC₅₀	> 10 μM Compound: 3	Antiproliferative activity against mouse L5178Y cells harboring human ABCB1 after 72 hrs by MTT assay Antiproliferative activity against mouse L5178Y cells harboring human ABCB1 after 72 hrs by MTT assay	[PMID: 30199257]
MRC5	IC₅₀	> 10 μM Compound: 3	Cytotoxicity against human MRC5 cells after 24 hrs by MTT assay Cytotoxicity against human MRC5 cells after 24 hrs by MTT assay	[PMID: 30199257]
NIH3T3	IC₅₀	> 10 μM Compound: 3	Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 24 hrs by MTT assay	[PMID: 30199257]

Molecular Weight

412.69

Formula

C₂₉H₄₈O

CAS No.

1058-61-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=CC(CC4)=O)C

Structure Classification

Steroids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 2.5 mg/mL (6.06 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4231 mL	12.1156 mL	24.2313 mL
5 mM	0.4846 mL	2.4231 mL	4.8463 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB) HNMR (258 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Aguilar-Guadarrama AB, et al. Flavonoids, Sterols and Lignans from Cochlospermum vitifolium and Their Relationship with Its Liver Activity. Molecules. 2018 Aug 5;23(8):1952. [Content Brief]

[2]. Chu CW, et al. Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties. Molecules. 2015 Jul 3;20(7):12166-74. [Content Brief]

[3]. Fan SQ, et al. Sarocladione, a unique 5,10:8,9-diseco-steroid from the deep-sea-derived fungus Sarocladium kiliense. Org Biomol Chem. 2019 Jun 18;17(24):5925-5928. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4231 mL	12.1156 mL	24.2313 mL	60.5782 mL
DMSO	5 mM	0.4846 mL	2.4231 mL	4.8463 mL	12.1156 mL

β-Sitostenone Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Sitostenone1058-61-3Δ4-Sitosterol-3-one β-Rosasterol oxideTyrosinaseEndogenous MetaboliteAnti-tumoranti-melanogenicInhibitorinhibitorinhibit

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β-Sitostenone (Synonyms: Δ4-Sitosterol-3-one; β-Rosasterol oxide)

β-Sitostenone Related Antibodies

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