2. Neuronal Signaling
  3. Amyloid-β
  4. γ-Secretase modulator 13

γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease.

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γ-Secretase modulator 13 Chemical Structure

γ-Secretase modulator 13 Chemical Structure

CAS No. : 1353570-40-7

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Description

γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease[1].

Cellular Effect
Cell Line Type Value Description References
SH-SY5Y IC50
163 nM
Compound: 6
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
Modulation of gamma-secretase in human SH-SY5Y cells overexpressing wild-type human APP751 assessed as inhibition of Abeta42 level after 24 hrs by ELISA
[PMID: 27426299]
Molecular Weight

422.52

Formula

C22H23FN6S
CAS No.
SMILES

FC1=C(N2C=NC(C)=C2)C=CC(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)=C1
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Purity & Documentation
References
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γ-Secretase modulator 13 Related Classifications

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Keywords:

γ-Secretase modulator 131353570-40-7Amyloid-ββ-amyloid peptideAβAbetagamma-secretase modulatorGSMsaggregated amyloid β-peptideAβ42Alzheimer's diseaseInhibitorinhibitorinhibit

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