2. Neuronal Signaling
  3. Sigma Receptor
  4. σ1 Receptor antagonist 4

σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters.

For research use only. We do not sell to patients.

σ1 Receptor antagonist 4 Chemical Structure

σ1 Receptor antagonist 4 Chemical Structure

CAS No. : 362512-81-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

σ1 Receptor antagonist 4 Related Antibodies

Top Publications Citing Use of Products

View All Sigma Receptor Isoform Specific Products:

View All Isoforms
Sigma 1 Receptor Sigma 2 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

σ1 Receptor antagonist 4 (compound TC1) is a selective sigma1 (σ1) receptor antagonist with a Ki of 10 nM. σ1 Receptor antagonist 4 is weakly active at σ2 receptor (Ki of 370 nM) and has no activity at dopamine (DAT), serotonin (SERT), and norepinephrine (NET) transporters[1].

IC50 & Target[1]

σ1R

10 nM (Ki)

σ2

370 nM (Ki)

In Vivo

σ1 Receptor antagonist 4 (compound TC1; 3-100 mg/kg; ip; once) attenuats the stimulatory locomotor effect of 20 mg/kg Cocaine with a half-maximal depressant activity (ID50) of 38.6 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss-Webster mice (Hsd:ND4, aged 2-3 month) injected with Cocaine[1]
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg, 100 mg/kg
Administration: i.p.; once
Result: Attenuated the stimulatory locomotor effect of 20 mg/kg Cocaine.
Molecular Weight

297.37

Formula

C19H20FNO
CAS No.
SMILES

OC12[C@H]3[C@@H]4C(C5C2C6[C@@H]3[C@H]4C5C6)N1CCC7=CC(F)=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

σ1 Receptor antagonist 4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

σ1 Receptor antagonist 4362512-81-0Sigma Receptorσ1 receptor antagonistInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
σ1 Receptor antagonist 4
Cat. No.:
HY-108513
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.