1-O-Hexadecylglycerol (Synonyms: 1-O-HDG; HXDG)

Cat. No.: HY-W011309 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-O-Hexadecylglycerol can up-regulate PPAR-γ expression, inhibit pGE2, and exhibit anti-inflammatory properties. 1-O-Hexadecylglycerol is effective in oral administration.

For research use only. We do not sell to patients.

1-O-Hexadecylglycerol Chemical Structure

CAS No. : 6145-69-3

Size	Price	Stock	Quantity
250 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 75	In-stock	Estimated Time of Arrival: December 31
5 g		Get quote
10 g		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

1-O-Hexadecylglycerol can up-regulate PPAR-γ expression, inhibit pGE2, and exhibit anti-inflammatory properties^[1]. 1-O-Hexadecylglycerol is effective in oral administration^[2].

IC₅₀ & Target^[1]

PPAR-γ

Molecular Weight

316.53

Formula

C₁₉H₄₀O₃

CAS No.

6145-69-3

Appearance

Solid

Color

White to off-white

SMILES

OC(CO)COCCCCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (631.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1593 mL	15.7963 mL	31.5926 mL
5 mM	0.6319 mL	3.1593 mL	6.3185 mL
10 mM	0.3159 mL	1.5796 mL	3.1593 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (15.80 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (266 KB) SDS (393 KB)

COA (238 KB) HNMR (244 KB) MS (83 KB)

Handling Instructions (2659 KB)

References

[1]. Yokota M, et al. Chimyl Alcohol Suppresses PGE2 Synthesis by Human Epidermal Keratinocytes through the Activation of PPAR-γ. J Oleo Sci. 2018 Apr 1;67(4):455-462. [Content Brief]

[2]. BLOMSTRAND R et al Absorption of chimyl alcohol in man. Proc Soc Exp Biol Med. 1959 Apr;100(4):802-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1593 mL	15.7963 mL	31.5926 mL	78.9815 mL
	5 mM	0.6319 mL	3.1593 mL	6.3185 mL	15.7963 mL
	10 mM	0.3159 mL	1.5796 mL	3.1593 mL	7.8981 mL
	15 mM	0.2106 mL	1.0531 mL	2.1062 mL	5.2654 mL
	20 mM	0.1580 mL	0.7898 mL	1.5796 mL	3.9491 mL
	25 mM	0.1264 mL	0.6319 mL	1.2637 mL	3.1593 mL
	30 mM	0.1053 mL	0.5265 mL	1.0531 mL	2.6327 mL
	40 mM	0.0790 mL	0.3949 mL	0.7898 mL	1.9745 mL
	50 mM	0.0632 mL	0.3159 mL	0.6319 mL	1.5796 mL
	60 mM	0.0527 mL	0.2633 mL	0.5265 mL	1.3164 mL
	80 mM	0.0395 mL	0.1975 mL	0.3949 mL	0.9873 mL
	100 mM	0.0316 mL	0.1580 mL	0.3159 mL	0.7898 mL

1-O-Hexadecylglycerol Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-O-Hexadecylglycerol6145-69-31-O-HDG HXDGPPARPGE synthasePeroxisome proliferator-activated receptorsProstaglandin E synthaseAnti-inflammatoryAntioxidantNHEK cellInhibitorinhibitorinhibit

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